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Linezolid

利奈唑胺,雷奈佐利,吗啉恶酮,利萘唑酮,PNU-100766,PNU 100766,PNU100766

Linezolid是一种合成的抗生素,用于治疗严重感染。

目录号
EY1109
EY1109
EY1109
EY1109
纯度
99.62%
99.62%
99.62%
99.62%
规格
1 mg
5 mg
10 mg
50 mg
原价
150
320
515
1700
售价
150
320
515
1700
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Linezolid is a synthetic antibiotic used for the treatment of serious infections.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Swaney SM, et al. Antimicrob Agents Chemother, 1998, 42(12), 3251-3255.

    分子式
    C16H20FN3O4
    分子量
    337.35
    CAS号
    165800-03-3
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    ≥60 mg/mL
    Water
    <1 mg/mL
    Ethanol
    8 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02778828 Tuberculosis Drug: Linezolid Groupe Hospitalier Paris Saint Joseph 2015-12-10 2017-02-19
    NCT01224626 Vancomycin Resistance Enterococcus Faecium Drug: Zyvox (linezolid) Pfizer 2006-05-01 2012-05-29
    NCT00625703 Cystic Fibrosis Drug: Linezolid University of Texas Southwestern Medical Center|Cystic Fibrosis Foundation Therapeutics Phase 2 2008-05-01 2009-01-21
    NCT01055769 Healthy Volunteers Drug: Linezolid|Drug: Linezolid Pfizer Phase 1 2010-03-01 2012-01-30
    NCT00691392 Multi-Drug Resistant Tuberculosis|Extensively Drug Resistant Tuberculosis Drug: Linezolid|Drug: Microcrystalline Methylcellulose - Placebo Centers for Disease Control and Prevention|University of Texas|Columbia University|University of KwaZulu|University of Cape Town|Boston University|Pfizer Phase 1|Phase 2 2009-04-01 2012-08-15
    NCT01200654 Methicillin-Resistant Staphylococcus AureuS Drug: Linezolid University Hospital, Toulouse Phase 4 2007-11-01 2012-10-22
    NCT01805284 Pneumonia Drug: Linezolid University Ghent|University Hospital, Ghent|Pfizer Phase 4 2013-02-01 2015-06-03
    NCT02269319 Bacterial Infections Drug: MRX-I|Drug: Linezolid MicuRx Phase 2 2015-02-01 2017-01-16
    NCT00359632 Optic Nerve Diseases Drug: Zyvox - linezolid|Drug: Matched control Pfizer Phase 3 2008-11-01 2015-06-03
    NCT00666276 Staphylococcal Infections Drug: linezolid (Zyvox) Pfizer 2007-02-01 2012-05-29
    NCT00727844 Pulmonary Tuberculosis|Multidrug Resistant Tuberculosis|Extensively Drug Resistant Tuberculosis Drug: Immediate Start Linezolid|Drug: Delayed Start Linezolid National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 2008-07-01 2016-02-12
    NCT02877927 Bacterial Infections|Skin Structures and Soft Tissue Infections Drug: Omadacycline|Drug: Linezolid Paratek Pharmaceuticals Inc Phase 3 2016-08-01 2017-03-01
    NCT02378480 Bacterial Infections|Skin Structures and Soft Tissue Infections Drug: Omadacycline|Drug: Linezolid Paratek Pharmaceuticals Inc Phase 3 2015-06-01 2016-07-06
    NCT01170221 Skin and Subcutaneous Tissue Bacterial Infections Drug: TR-701 FA|Drug: Linezolid Trius Therapeutics LLC Phase 3 2010-08-01 2016-05-18
    NCT01561469 Methicillin-Resistant Staphylococcus Aureus (MRSA)|Hospital-Acquired Pneumonia Drug: Linezolid|Drug: Vancomycin Pfizer|University of Louisville|Henry Ford Hospital|Summa Health System|Sparrow Health System|Jackson Health System 2008-11-01 2014-06-09
    NCT00255996 Burns Drug: linezolid Pfizer Phase 1 2006-05-01 2009-07-13
    NCT00664313 Multi-drug Resistant Tuberculosis|Extensively Drug Resistant Tuberculosis Drug: Linezolid|Drug: Placebo Centers for Disease Control and Prevention|University of KwaZulu|Columbia University|Yale University Phase 1|Phase 2 2009-04-01 2012-10-01
    NCT01040585 Ventilator Acquired Pneumonia Drug: Linezolid Pfizer Phase 4 2010-07-01 2012-03-01

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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