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Reserpine

利血平,蛇根草素,阿达芬,Serpalan

Reserpine是一种吲哚生物碱,能不可逆地阻断囊泡单胺转运体(VMAT),有抗高血压的效果。

目录号
EY1101
EY1101
纯度
99.26%
99.26%
规格
50 mg
100 mg
原价
270
480
售价
270
480
库存
现货
现货
订购
订购
订购
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  • 生物活性

    Reserpine is an inhibitor of multidrug efflux pumps, used as an antipsychotic and antihypertensive drug.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Schmitz FJ, et al. J Antimicrob Chemother, 1998, 42(6), 807-810.

    分子式
    C33H40N2O9
    分子量
    608.68
    CAS号
    50-55-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    100 mM
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00033033 Cocaine-Related Disorders|Substance-Related Disorders Drug: Reserpine National Institute on Drug Abuse (NIDA)|Cincinnati VA Medical Center Phase 2 2001-07-01 2017-01-11
    NCT00267657 Amphetamine-Related Disorders Drug: Reserpine National Institute on Drug Abuse (NIDA) Phase 1 2004-01-01 2017-01-10
    NCT02684786 Pulmonary Artery Hypertension Drug: reserpine|Procedure: stellate ganglion block|Drug: lidocaine Mayo Clinic Phase 1 2016-03-01 2016-02-17
    NCT00000514 Cardiovascular Diseases|Cerebrovascular Disorders|Heart Diseases|Hypertension Drug: chlorthalidone|Drug: atenolol|Drug: reserpine National Heart, Lung, and Blood Institute (NHLBI)|National Institute on Aging (NIA) Phase 3 1984-06-01 2016-04-14
    NCT00015106 Cocaine-Related Disorders Drug: Lamotrigine National Institute on Drug Abuse (NIDA) Phase 2 1997-11-01 2017-01-11
    NCT00000499 Cardiovascular Diseases|Heart Diseases|Hypertension|Vascular Diseases Drug: chlorthalidone|Drug: reserpine|Drug: hydralazine|Drug: metoprolol National Heart, Lung, and Blood Institute (NHLBI)|National Institute on Aging (NIA) Phase 2 1980-09-01 2013-11-25
    NCT00362804 Schizophrenia|Schizoaffective Disorder Drug: Tetrabenazine Centre for Addiction and Mental Health|Stanley Medical Research Institute 2002-02-01 2012-07-04
    NCT01108029 Parkinson's Disease|Gait Disorders, Neurologic Drug: memantine|Drug: placebo University Hospital, Lille Phase 4 2009-10-01 2012-03-23
    NCT00684489 Hypertension Drug: clinical hypertension specialist-no specific med. Any anti-hypertension meds.|Drug: renin guided therapeutics-no specific med. Any anti-hypertensive med. Medical University of South Carolina|New York Presbyterian Hospital 2003-09-01 2008-05-22
    NCT00000620 Atherosclerosis|Cardiovascular Diseases|Hypercholesterolemia|Hypertension|Diabetes Mellitus, Type 2|Diabetes Mellitus|Coronary Disease Drug: Anti-hyperglycemic Agents|Drug: Anti-hypertensive Agents|Drug: Blinded fenofibrate or placebo plus simvastatin National Heart, Lung, and Blood Institute (NHLBI)|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institute on Aging (NIA)|National Eye Institute (NEI)|Centers for Disease Control and Prevention Phase 3 1999-09-01 2016-11-21

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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