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Desloratadine

地氯雷他定,SCH-34117,NSC 675447,SCH34117,SCH 34117,NSC-675447,NSC675447,

Desloratadine是一种有效的人组胺H1受体拮抗剂，IC50为51nM.

目录号
EY1100
EY1100
EY1100
纯度
99.67%
99.67%
99.67%
规格
50 mg
100 mg
500 mg
原价
470
690
2700
售价
470
690
2700
库存
现货
现货
现货
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  • 生物活性

    Desloratadine is a potent antagonist for human histamine H1 receptor with IC50 of 51 nM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

    10mg/kg皮下注射

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Yoko Nagaya et. Al. Drug Metabolism and Pharmacokinetics, 29(5), 419-426 (2014).
    [2] Shigeru Hishinuma et. Al. Biochemical Pharmacology, 91(2), 231-241 (2014).

    分子式
    C19H19ClN2    		 分子量
    310.82    		 CAS号
    100643-71-8    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    26 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    60 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00817076 Dermatitis, Atopic Drug: desloratadine Merck Sharp & Dohme Corp. Phase 3 2003-03-01 2015-04-20
    NCT01314352 Fed Drug: Desloratadine Dr. Reddy's Laboratories Limited Phase 1 2005-12-01 2011-06-07
    NCT01314339 Fasting Drug: Desloratadine Dr. Reddy's Laboratories Limited Phase 1 2005-12-01 2012-02-17
    NCT00536380 Chronic Idiopathic Urticaria Drug: 5-mg Desloratadine|Drug: 10-mg Desloratadine|Drug: 20-mg Desloratadine Merck Sharp & Dohme Corp. Phase 4 2007-09-01 2015-10-15
    NCT01506037 Healthy Drug: Desloratadine Dr. Reddy's Laboratories Limited Phase 1 2006-01-01 2012-01-10
    NCT01506050 Healthy Drug: Desloratadine Dr. Reddy's Laboratories Limited Phase 1 2006-01-01 2012-01-06
    NCT00805324 Rhinitis, Allergic, Seasonal|Asthma Drug: Desloratadine Merck Sharp & Dohme Corp. Phase 3 2003-05-01 2015-04-20
    NCT00867191 Seasonal Allergic Rhinitis Drug: Placebo|Drug: Desloratadine Merck Sharp & Dohme Corp. Phase 4 2002-02-01 2017-03-21
    NCT00779116 Allergies Drug: Desloratadine|Drug: Zyrtec(cetirizine) Merck Sharp & Dohme Corp. Phase 4 2005-09-01 2015-04-06
    NCT01506791 Healthy Drug: Desloratadine and pseudoephedrine Dr. Reddy's Laboratories Limited Phase 1 2006-04-01 2012-01-05
    NCT01373138 Healthy Drug: Desloratadine and pseudoephedrine Dr. Reddy's Laboratories Limited Phase 1 2006-04-01 2011-06-13
    NCT00724698 Rhinitis|Urticaria Drug: Desloratadine Merck Sharp & Dohme Corp. 2005-10-01 2016-01-22
    NCT00757562 Chronic Idiopathic Urticaria|Atopy Drug: desloratadine|Drug: Placebo Merck Sharp & Dohme Corp. Phase 3 2002-11-01 2017-03-21
    NCT00761527 Rhinitis, Allergic, Seasonal|Rhinitis, Allergic, Perennial|Urticaria Drug: Desloratadine Syrup Merck Sharp & Dohme Corp. 2008-03-01 2015-07-15
    NCT00789152 Allergic Rhinitis Drug: desloratadine|Drug: levocetirizine Merck Sharp & Dohme Corp. Phase 3 2003-12-01 2017-03-22
    NCT00794794 Allergic Rhinitis Drug: Desloratadine (Clarinex)|Drug: Cetirizine (Zyrtec) Merck Sharp & Dohme Corp. Phase 3 2004-11-01 2015-09-21
    NCT00794378 Allergic Rhinitis Drug: Desloratadine (Clarinex)|Drug: Cetirizine (Zyrtec) Merck Sharp & Dohme Corp. Phase 3 2004-11-01 2015-07-03
    NCT02646020 Non-small Cell Lung Cancer Drug: Aprepitant and placebo|Drug: desloratadine and placebo Sun Yat-sen University Phase 2 2015-12-01 2016-01-02
    NCT00779636 Allergic Airway Disease Drug: Desloratadine|Drug: Placebo Merck Sharp & Dohme Corp. Phase 4 2003-07-01 2017-03-21
    NCT00795158 Urticaria Drug: desloratadine Merck Sharp & Dohme Corp. Phase 3 2002-11-01 2015-05-04
    NCT00780403 Allergies Drug: Desloratadine|Drug: Zyrtec(cetirizine) Merck Sharp & Dohme Corp. Phase 4 2005-08-01 2015-09-21
    NCT00405964 Allergic Rhinitis Drug: 5-mg Desloratadine|Drug: Placebo tablet Merck Sharp & Dohme Corp. Phase 3 2006-09-01 2015-04-09
    NCT00406783 Rhinitis, Allergic, Seasonal|Rhinitis, Allergic, Perennial Drug: 5-mg Desloratadine|Drug: Placebo Merck Sharp & Dohme Corp. Phase 3 2006-08-01 2015-05-15
    NCT00805584 Rhinitis, Allergic, Seasonal Drug: desloratadine Merck Sharp & Dohme Corp. Phase 4 2003-05-01 2015-04-20

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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