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Etidronate

依替膦酸钠,羟乙膦酸钠

Etidronic acid是一种应用于洗涤,水处理,化妆品和制药业的双磷酸盐。

目录号
EY1095
EY1095
纯度
99.44%
99.44%
规格
500 mg
1 g
原价
375
620
售价
375
620
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Etidronate is a non-aminobisphosphonate, show protein tyrosine phosphatase (PTP) inhibitory activity, used for the treatment of Paget's disease and the prevention of heterotopic ossification.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Hiroi-Furuya E, et al. Calcif Tissue Int, 1999, 64(3), 219-223.

    分子式
    C2H8O7P2
    分子量
    206.03
    CAS号
    2809-21-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    <1 mg/mL
    Water
    40 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00376662 Osteoporosis Drug: Hormone Replacement Therapy and Etidronate British Thoracic Society Phase 4 1992-08-01 2006-09-13
    NCT01585402 Arterial Calcification Due to CD73-Deficiency (ACDC) Drug: Etidronate|Procedure: MRI|Procedure: CT Scan|Procedure: ABI|Procedure: Treadmill|Procedure: Dexa Scan|Procedure: Hand X-ray National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) Phase 1 2012-04-09 2017-03-07
    NCT02673060 Bone Metastasis Drug: MBC-11 Osteros Biomedica Ltd Phase 1 2014-07-01 2016-03-28
    NCT01077817 Esophageal Cancer|Squamous Cell Carcinoma|Adenocarcinoma Drug: Alendronate|Drug: Etidronate|Drug: Ibandronate|Drug: Risedronate|Drug: Raloxifene Merck Sharp & Dohme Corp.|World Health Information Science Consultants, LLC 2010-02-01 2015-04-27
    NCT01215890 Crohn's Disease|Low Bone Mineral Density Drug: risedronate|Drug: placebo University of Alberta Phase 4 2010-10-05
    NCT00679978 Vertebral Fracture|Osteonecrosis|Rheumatic Diseases Saitama Medical University Phase 4 2001-01-01 2009-09-17
    NCT00261625 End-Stage Renal Disease|Osteoporosis Drug: alendronate National Taiwan University Hospital Phase 4 2005-08-01 2009-01-02
    NCT00062595 Osteoporosis Drug: phylloquinone (K1)|Drug: menatetranone (MK4) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Eisai Co., Ltd. Phase 3 2000-09-01 2016-05-16
    NCT00843466 Hand Dermatosis Other: Mild, moisturizing hand cleanser Wake Forest University|Wake Forest University Health Sciences 2007-05-01 2017-01-26
    NCT02731040 Atypical Femoral Fractures|Osteoporosis|Bisphosphonate Therapy Drug: Bisphosphonate Washington University School of Medicine 2016-04-01 2016-04-15
    NCT02744482 Prosthesis Loosening Drug: risedronate|Drug: placebo University Hospital, Limoges Phase 3 2016-05-01 2016-08-11
    NCT02106455 Osseous Paget's Disease Drug: Sodium risedronate Takeda 2013-05-01 2016-08-31
    NCT02106442 Osteoporosis Drug: Sodium risedronate Takeda 2013-05-01 2016-11-16
    NCT02089997 Osteoporosis Drug: Sodium risedronate Takeda 2013-05-01 2016-07-14
    NCT01406444 Anorexia Nervosa|Osteopenia|Osteoporosis Drug: rhIGF-1|Drug: Risedronate|Drug: Placebo Massachusetts General Hospital 2011-10-01 2017-01-19
    NCT01249261 Postmenopausal Women With Osteoporosis Drug: Risedronate|Drug: Placebo/Risedronate Warner Chilcott Phase 3 2001-10-01 2011-10-27
    NCT00918749 Postmenopausal Osteoporosis Drug: 150 mg|Drug: 75 mg|Drug: 100 mg Warner Chilcott Phase 2 2009-05-01 2015-06-01
    NCT00859027 Prostate Cancer Drug: risedronate|Drug: placebo UConn Health|Proctor and Gamble/Aventis Phase 4 2003-01-01 2013-06-28
    NCT00846196 Osteoporosis Drug: risedronate DR (Phase III clinical supply)|Drug: risedronate 35 mg DR (Commercial Tablet) Warner Chilcott|Sanofi Phase 1 2009-01-01 2011-10-07
    NCT00837746 Osteoporosis Drug: risedronate Warner Chilcott|Sanofi Phase 4 2003-04-01 2013-06-03
    NCT00772395 Bone Loss Drug: Risedronate|Drug: Placebo Danderyd Hospital|Sanofi Phase 4 2006-04-01 2014-09-18

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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