Etidronic acid是一种应用于洗涤,水处理,化妆品和制药业的双磷酸盐。
Etidronate is a non-aminobisphosphonate, show protein tyrosine phosphatase (PTP) inhibitory activity, used for the treatment of Paget's disease and the prevention of heterotopic ossification.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Hiroi-Furuya E, et al. Calcif Tissue Int, 1999, 64(3), 219-223.
分子式 C2H8O7P2 |
分子量 206.03 |
CAS号 2809-21-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO <1 mg/mL |
Water 40 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00376662 | Osteoporosis | Drug: Hormone Replacement Therapy and Etidronate | British Thoracic Society | Phase 4 | 1992-08-01 | 2006-09-13 |
NCT01585402 | Arterial Calcification Due to CD73-Deficiency (ACDC) | Drug: Etidronate|Procedure: MRI|Procedure: CT Scan|Procedure: ABI|Procedure: Treadmill|Procedure: Dexa Scan|Procedure: Hand X-ray | National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) | Phase 1 | 2012-04-09 | 2017-03-07 |
NCT02673060 | Bone Metastasis | Drug: MBC-11 | Osteros Biomedica Ltd | Phase 1 | 2014-07-01 | 2016-03-28 |
NCT01077817 | Esophageal Cancer|Squamous Cell Carcinoma|Adenocarcinoma | Drug: Alendronate|Drug: Etidronate|Drug: Ibandronate|Drug: Risedronate|Drug: Raloxifene | Merck Sharp & Dohme Corp.|World Health Information Science Consultants, LLC | 2010-02-01 | 2015-04-27 | |
NCT01215890 | Crohn's Disease|Low Bone Mineral Density | Drug: risedronate|Drug: placebo | University of Alberta | Phase 4 | 2010-10-05 | |
NCT00679978 | Vertebral Fracture|Osteonecrosis|Rheumatic Diseases | Saitama Medical University | Phase 4 | 2001-01-01 | 2009-09-17 | |
NCT00261625 | End-Stage Renal Disease|Osteoporosis | Drug: alendronate | National Taiwan University Hospital | Phase 4 | 2005-08-01 | 2009-01-02 |
NCT00062595 | Osteoporosis | Drug: phylloquinone (K1)|Drug: menatetranone (MK4) | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Eisai Co., Ltd. | Phase 3 | 2000-09-01 | 2016-05-16 |
NCT00843466 | Hand Dermatosis | Other: Mild, moisturizing hand cleanser | Wake Forest University|Wake Forest University Health Sciences | 2007-05-01 | 2017-01-26 | |
NCT02731040 | Atypical Femoral Fractures|Osteoporosis|Bisphosphonate Therapy | Drug: Bisphosphonate | Washington University School of Medicine | 2016-04-01 | 2016-04-15 | |
NCT02744482 | Prosthesis Loosening | Drug: risedronate|Drug: placebo | University Hospital, Limoges | Phase 3 | 2016-05-01 | 2016-08-11 |
NCT02106455 | Osseous Paget's Disease | Drug: Sodium risedronate | Takeda | 2013-05-01 | 2016-08-31 | |
NCT02106442 | Osteoporosis | Drug: Sodium risedronate | Takeda | 2013-05-01 | 2016-11-16 | |
NCT02089997 | Osteoporosis | Drug: Sodium risedronate | Takeda | 2013-05-01 | 2016-07-14 | |
NCT01406444 | Anorexia Nervosa|Osteopenia|Osteoporosis | Drug: rhIGF-1|Drug: Risedronate|Drug: Placebo | Massachusetts General Hospital | 2011-10-01 | 2017-01-19 | |
NCT01249261 | Postmenopausal Women With Osteoporosis | Drug: Risedronate|Drug: Placebo/Risedronate | Warner Chilcott | Phase 3 | 2001-10-01 | 2011-10-27 |
NCT00918749 | Postmenopausal Osteoporosis | Drug: 150 mg|Drug: 75 mg|Drug: 100 mg | Warner Chilcott | Phase 2 | 2009-05-01 | 2015-06-01 |
NCT00859027 | Prostate Cancer | Drug: risedronate|Drug: placebo | UConn Health|Proctor and Gamble/Aventis | Phase 4 | 2003-01-01 | 2013-06-28 |
NCT00846196 | Osteoporosis | Drug: risedronate DR (Phase III clinical supply)|Drug: risedronate 35 mg DR (Commercial Tablet) | Warner Chilcott|Sanofi | Phase 1 | 2009-01-01 | 2011-10-07 |
NCT00837746 | Osteoporosis | Drug: risedronate | Warner Chilcott|Sanofi | Phase 4 | 2003-04-01 | 2013-06-03 |
NCT00772395 | Bone Loss | Drug: Risedronate|Drug: Placebo | Danderyd Hospital|Sanofi | Phase 4 | 2006-04-01 | 2014-09-18 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
相关化合物库
使用AMQUAR产品发表文献后请联系我们