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TIC10

ONC201 isomer,ONC 201,TIC-10,TIC 10,ONC-201,NSC 350625,NSC350625,NSC-350625

TIC10是口服活性的稳定化合物,能抑制Akt和ERK,能透过血脑屏障,可诱导TRAIL。

目录号
EY1092
EY1092
EY1092
纯度
99.35%
99.35%
99.35%
规格
5 mg
10 mg
50 mg
原价
840
1150
3200
售价
840
1150
3200
库存
现货
现货
现货
订购
订购
订购
订购
订购
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  • 生物活性

    TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

    25, 50, 100 mg/kg 腹腔处理/口服处理

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Allen JE, et al. Sci Transl Med, 2013, 5(171), 171ra17.

    分子式
    C24H26N4O
    分子量
    386.49
    CAS号
    41276-02-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    6 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02038699 Advanced Glioblastoma|Advanced Colorectal Cancer|Advanced Triple-negative Breast Cancer|Advanced Non-small Cell Lung Cancer Drug: ONC201 Oncoceutics, Inc. Phase 1|Phase 2 null 2015-12-18
    NCT02250781 Solid Tumors Drug: Oral ONC201 Rutgers, The State University of New Jersey|National Cancer Institute (NCI)|Rutgers Cancer Institute of New Jersey Phase 1 2015-01-01 2017-02-01
    NCT02324621 Unspecified Adult Solid Tumor Drug: Oral ONC201|Other: pharmacological study|Other: laboratory biomarker analysis Rutgers, The State University of New Jersey|National Cancer Institute (NCI)|Rutgers Cancer Institute of New Jersey|Oncoceutics, Inc. Phase 1 2015-02-01 2017-01-19
    NCT02863991 Multiple Myeloma Drug: ONC201 Oncoceutics, Inc. Phase 1|Phase 2 2016-01-01 2017-03-20
    NCT03034200 Recurrent Neuroendocrine Tumor|Metastatic Neuroendocrine Tumor Drug: ONC201 Peter Anderson|Case Comprehensive Cancer Center Phase 2 2017-02-01 2017-01-25
    NCT02420795 Lymphoma Drug: ONC201|Behavioral: Phone Call M.D. Anderson Cancer Center|Oncoceutics, Inc. Phase 1|Phase 2 2015-11-03 2017-01-23
    NCT02609230 Advanced Solid Tumors|Multiple Myeloma Drug: ONC-201 Fox Chase Cancer Center Phase 1 2015-11-01 2017-01-25
    NCT02392572 Leukemia Drug: ONC201 M.D. Anderson Cancer Center|Oncoceutics, Inc. Phase 1|Phase 2 2015-11-01 2016-12-27
    NCT02525692 Recurrent Glioblastoma Drug: ONC201 Oncoceutics, Inc. Phase 2 2016-01-01 2017-03-19
    NCT02190721 Solid Tumors Drug: tbo-filgrastim Teva Pharmaceutical Industries Phase 2 2015-05-01 2017-03-13

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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