Home > Histamine Receptor & Histamine Receptor & > Chlorpheniramine Maleate

Chlorpheniramine Maleate

马来酸氯苯那敏,NCI-C55265,NCIC55265,NCI C55265,

Chlorpheniramine是组胺H1受体拮抗剂,IC50为12 nM。

目录号
EY1074
EY1074
纯度
99.38%
99.38%
规格
1 g
5 g
原价
180
430
售价
180
430
库存
现货
现货
订购
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  • 生物活性

    Chlorpheniramine (Chlorpheniramine maleate, Chlorphenamine) is an histamine H1 receptor antagonist with IC50 of 12 nM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    溶于水,~500 μM

  • 动物实验

    10 mg/kg 口服处理

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Iemura R, et al. J Med Chem, 1986, 29(7), 1178-1183.

    分子式
    C20H23ClN2O4
    分子量
    390.86
    CAS号
    113-92-8
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    80 mg/mL
    Water
    80 mg/mL
    Ethanol
    80 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01008397 Rhinitis, Allergic, Seasonal Drug: AHIST NDC#58407-012-01 Magna Pharmaceuticals, Inc. Phase 1 2011-04-01 2014-03-04
    NCT00837837 Allergic Reactions Drug: Chlorpheniramine Wyeth is now a wholly owned subsidiary of Pfizer Phase 2 2008-12-01 2013-02-21
    NCT00853294 Healthy Drug: Chlorpheniramine polistirex equivalent to 8 mg of chlorpheniramine maleate and hydrocodone polistirex equivalent to 10 mg of hydrocodone bitartrate capsule|Drug: 5 mL chlorpheniramine (8 mg/5 mL)/hydrocodone (10 mg/5 mL) extended release oral suspension Mallinckrodt Phase 1 2003-09-01 2016-10-18
    NCT00853190 Healthy Drug: Chlorpheniramine polistirex equivalent to 8 mg of chlorpheniramine maleate and hydrocodone polistirex equivalent to 10 mg of hydrocodone bitartrate capsule|Drug: 5 mL chlorpheniramine (8 mg/5 mL)/hydrocodone (10 mg/5 mL) extended release oral suspension Mallinckrodt Phase 1 2003-09-01 2016-10-18
    NCT02246166 Common Cold Drug: Test tablet|Other: Placebo GlaxoSmithKline|Sino-American Tianjin Smith Kline & French Laboratories Ltd Phase 4 2015-01-01 2016-08-02
    NCT01389518 Flu Drug: Active|Drug: Placebo Hospital de Clinicas de Porto Alegre Phase 3 2009-05-01 2011-11-24
    NCT01158326 Common Cold|Influenza Drug: Resfenol|Other: Placebo Hospital de Clinicas de Porto Alegre Phase 3 2010-08-01 2011-11-24
    NCT02082054 Rhinitis, Seasonal, Allergic Drug: PSE 120 mg, CM 8 mg, Atr 0.36 mg|Drug: PSE 120 mg, CM 8 mg, Atr 0.24 mg|Drug: PSE 120 mg, CM 8 mg, Atr 0.12 mg|Drug: PSE 120 mg, CM 8 mg|Drug: Atropine 0.24 mg Magna Pharmaceuticals, Inc. Phase 2 2014-03-01 2014-05-28
    NCT00940836 Common Cold|Flu-like Syndrome Drug: Resfenol|Drug: Placebo|Drug: Co interventional acetaminophen Hospital de Clinicas de Porto Alegre Phase 3 2009-06-01 2009-07-15
    NCT00932256 Rhinitis, Allergic, Seasonal Drug: STAHIST NDC #58407-536-01 Magna Pharmaceuticals, Inc. Phase 1 2009-10-01 2010-12-06
    NCT02722083 Rhinitis, Allergic Drug: Chlorpheniramine maleate (BAY X002134)|Drug: Placebo Bayer Phase 2 2016-05-01 2017-02-16
    NCT01454544 House Dust Mite Allergy Biological: AIT Tablet ALK-Abell A/S Phase 3 2011-10-01 2017-01-27
    NCT02656914 Flu Symptoms Drug: Guaifenesin and Ibuprofen and Loratadine|Drug: Resfenol EMS Phase 3 2017-07-01 2017-01-20
    NCT01902836 Childhood Atopic Dermatitis Biological: Conventional treatment plus DLE|Biological: Conventional treatment plus placebo National Polytechnic Institute, Mexico|Hospital Infantil de Mexico Federico Gomez|Instituto de Oftalmologa Fundacin Conde de Valenciana Phase 2 2011-08-01 2013-07-26
    NCT01209455 Poisoning Drug: Chlorphenamine and Ranitidine|Drug: Paracetamol|Drug: Paracetamol University of Edinburgh|NHS Lothian 2011-01-01 2011-07-18
    NCT01938144 Common Cold Drug: Advil Congestion Relief|Drug: Advil Allergy and Congestion Relief|Drug: Paracetamol Pfizer Phase 3 2016-04-01 2015-10-13
    NCT01293201 Seasonal Allergic Rhinitis Drug: STAHIST|Drug: Placebo Magna Pharmaceuticals, Inc. Phase 3 2011-03-01 2011-08-31
    NCT02418013 Aging Other: Fresh cord blood(experimental group A)|Other: Frozen cord blood(experimental group B)|Other: Frozen plasma(experimental group C)|Other: Placebo group Bundang CHA Hospital Phase 1 2015-03-01 2016-01-11
    NCT00376428 Cystic Fibrosis Drug: Gentamicin Assistance Publique - H么pitaux de Paris Phase 2 2003-01-01 2015-02-24
    NCT00555542 Rheumatoid Arthritis Drug: rituximab Chinese University of Hong Kong Phase 2 2006-07-01 2008-05-07
    NCT00770562 Idiopathic Thrombocytopenic Purpura Drug: rituximab|Drug: Dexamethasone Hoffmann-La Roche Phase 3 2005-07-01 2014-10-21

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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