Chlorpheniramine是组胺H1受体拮抗剂,IC50为12 nM。
Chlorpheniramine (Chlorpheniramine maleate, Chlorphenamine) is an histamine H1 receptor antagonist with IC50 of 12 nM.
溶于水,~500 μM
10 mg/kg 口服处理
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Iemura R, et al. J Med Chem, 1986, 29(7), 1178-1183.
分子式 C20H23ClN2O4 |
分子量 390.86 |
CAS号 113-92-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 80 mg/mL |
Water 80 mg/mL |
Ethanol 80 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01008397 | Rhinitis, Allergic, Seasonal | Drug: AHIST NDC#58407-012-01 | Magna Pharmaceuticals, Inc. | Phase 1 | 2011-04-01 | 2014-03-04 |
NCT00837837 | Allergic Reactions | Drug: Chlorpheniramine | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 2 | 2008-12-01 | 2013-02-21 |
NCT00853294 | Healthy | Drug: Chlorpheniramine polistirex equivalent to 8 mg of chlorpheniramine maleate and hydrocodone polistirex equivalent to 10 mg of hydrocodone bitartrate capsule|Drug: 5 mL chlorpheniramine (8 mg/5 mL)/hydrocodone (10 mg/5 mL) extended release oral suspension | Mallinckrodt | Phase 1 | 2003-09-01 | 2016-10-18 |
NCT00853190 | Healthy | Drug: Chlorpheniramine polistirex equivalent to 8 mg of chlorpheniramine maleate and hydrocodone polistirex equivalent to 10 mg of hydrocodone bitartrate capsule|Drug: 5 mL chlorpheniramine (8 mg/5 mL)/hydrocodone (10 mg/5 mL) extended release oral suspension | Mallinckrodt | Phase 1 | 2003-09-01 | 2016-10-18 |
NCT02246166 | Common Cold | Drug: Test tablet|Other: Placebo | GlaxoSmithKline|Sino-American Tianjin Smith Kline & French Laboratories Ltd | Phase 4 | 2015-01-01 | 2016-08-02 |
NCT01389518 | Flu | Drug: Active|Drug: Placebo | Hospital de Clinicas de Porto Alegre | Phase 3 | 2009-05-01 | 2011-11-24 |
NCT01158326 | Common Cold|Influenza | Drug: Resfenol|Other: Placebo | Hospital de Clinicas de Porto Alegre | Phase 3 | 2010-08-01 | 2011-11-24 |
NCT02082054 | Rhinitis, Seasonal, Allergic | Drug: PSE 120 mg, CM 8 mg, Atr 0.36 mg|Drug: PSE 120 mg, CM 8 mg, Atr 0.24 mg|Drug: PSE 120 mg, CM 8 mg, Atr 0.12 mg|Drug: PSE 120 mg, CM 8 mg|Drug: Atropine 0.24 mg | Magna Pharmaceuticals, Inc. | Phase 2 | 2014-03-01 | 2014-05-28 |
NCT00940836 | Common Cold|Flu-like Syndrome | Drug: Resfenol|Drug: Placebo|Drug: Co interventional acetaminophen | Hospital de Clinicas de Porto Alegre | Phase 3 | 2009-06-01 | 2009-07-15 |
NCT00932256 | Rhinitis, Allergic, Seasonal | Drug: STAHIST NDC #58407-536-01 | Magna Pharmaceuticals, Inc. | Phase 1 | 2009-10-01 | 2010-12-06 |
NCT02722083 | Rhinitis, Allergic | Drug: Chlorpheniramine maleate (BAY X002134)|Drug: Placebo | Bayer | Phase 2 | 2016-05-01 | 2017-02-16 |
NCT01454544 | House Dust Mite Allergy | Biological: AIT Tablet | ALK-Abell A/S | Phase 3 | 2011-10-01 | 2017-01-27 |
NCT02656914 | Flu Symptoms | Drug: Guaifenesin and Ibuprofen and Loratadine|Drug: Resfenol | EMS | Phase 3 | 2017-07-01 | 2017-01-20 |
NCT01902836 | Childhood Atopic Dermatitis | Biological: Conventional treatment plus DLE|Biological: Conventional treatment plus placebo | National Polytechnic Institute, Mexico|Hospital Infantil de Mexico Federico Gomez|Instituto de Oftalmologa Fundacin Conde de Valenciana | Phase 2 | 2011-08-01 | 2013-07-26 |
NCT01209455 | Poisoning | Drug: Chlorphenamine and Ranitidine|Drug: Paracetamol|Drug: Paracetamol | University of Edinburgh|NHS Lothian | 2011-01-01 | 2011-07-18 | |
NCT01938144 | Common Cold | Drug: Advil Congestion Relief|Drug: Advil Allergy and Congestion Relief|Drug: Paracetamol | Pfizer | Phase 3 | 2016-04-01 | 2015-10-13 |
NCT01293201 | Seasonal Allergic Rhinitis | Drug: STAHIST|Drug: Placebo | Magna Pharmaceuticals, Inc. | Phase 3 | 2011-03-01 | 2011-08-31 |
NCT02418013 | Aging | Other: Fresh cord blood(experimental group A)|Other: Frozen cord blood(experimental group B)|Other: Frozen plasma(experimental group C)|Other: Placebo group | Bundang CHA Hospital | Phase 1 | 2015-03-01 | 2016-01-11 |
NCT00376428 | Cystic Fibrosis | Drug: Gentamicin | Assistance Publique - H么pitaux de Paris | Phase 2 | 2003-01-01 | 2015-02-24 |
NCT00555542 | Rheumatoid Arthritis | Drug: rituximab | Chinese University of Hong Kong | Phase 2 | 2006-07-01 | 2008-05-07 |
NCT00770562 | Idiopathic Thrombocytopenic Purpura | Drug: rituximab|Drug: Dexamethasone | Hoffmann-La Roche | Phase 3 | 2005-07-01 | 2014-10-21 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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