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Tranexamic Acid

氨甲环酸,凝血酸

Tranexamic acid能阻断纤溶酶的赖氨酸结合位点和弹性蛋白酶来源的纤维蛋白溶酶原片段。

目录号
EY1065
EY1065
纯度
99.29%
99.29%
规格
100 mg
500 mg
原价
220
380
售价
220
380
库存
现货
现货
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  • 生物活性

    Tranexamic Acid is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Yao Lulu Xing et. Al. Journal of Neuroscience, 34(42), 14128-14146 (2014).
    [2] Aline A F Carmo et. Al. Journal of Immunology, 193(7), 3654-3663 (2014).
    [3] Xiaofei Wang and Xiao-Ming Xu. Experimental Neurology, 261, 308-319 (2014).

    分子式
    C8H15NO2    		 分子量
    157.21    		 CAS号
    1197-18-8    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    30 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01141127 Bleeding Drug: Tranexamic Acid Centre Chirurgical Marie Lannelongue Phase 2 2010-06-01 2014-07-21
    NCT00904709 Menorrhagia Drug: tranexamic acid K. Sue Robinson|Canadian Hemophilia Society|Nova Scotia Health Authority Phase 4 2009-10-19 2017-01-30
    NCT01655641 Gastric Cancer|Pancreatic Cancer|Hepatocellular Cancer|Colon Cancer Drug: Tranexamic acid|Other: Standard of care Tribhuvan University Teaching Hospital, Institute Of Medicine.|Pfizer Phase 2|Phase 3 2012-07-01 2012-10-14
    NCT01280981 Menorrhagia Drug: Tranexamic acid Ferring Pharmaceuticals|Xanodyne Pharmaceuticals Phase 3 2007-04-01 2011-06-28
    NCT01940419 Gynecologic Surgical Procedures|Hysterectomy|Tranexamic Acid Drug: Tranexamic Acid|Drug: Placebo Hillerod Hospital, Denmark|Rigshospitalet, Denmark|Odense University Hospital|Central Denmark Region|Research grant from Nordsj忙llands Hospital|The fund of Olga Bryde|The Danish hysterectomy and hysteroscopy database Phase 4 2013-04-01 2015-10-21
    NCT02094066 Hemorrhage Drug: tranexamic acid|Drug: serum physiologic TC Erciyes University Phase 4 2014-03-01 2014-03-24
    NCT01370460 Acute Blood Loss Anemia|Osteoarthritis, Knee Drug: Tranexamic Acid|Drug: Placebo Henry Ford Health System Phase 2 2011-06-01 2013-07-03
    NCT01846507 Heavy Menstrual Bleeding Drug: Tranexamic Acid Nationwide Children's Hospital Phase 4 2013-04-01 2017-02-10
    NCT01228136 Tonsillectomy|Adenoidectomy|Tranexamic Acid Drug: Tranexamic Acid|Other: normal saline solution Irmandade Santa Casa de Miseric贸rdia de Porto Alegre Phase 4 2010-01-01 2010-12-21
    NCT01005147 Gastrointestinal Hemorrhage Drug: tranexamic acid|Other: Placebo University of Oklahoma 2009-11-01 2012-04-05
    NCT02584725 Arthropathy of Hip|Arthropathy of Knee Drug: Tranexamic Acid Columbia University Phase 4 2014-12-01 2015-10-21
    NCT03019198 Blood Loss, Surgical|Tranexamic Acid Adverse Reaction|Hip Replacement Drug: Tranexamic Acid Injectable Solution|Drug: Placebo - Concentrate Instituto Nacional de Traumatologia e Ortopedia Phase 4 2013-12-01 2017-03-07
    NCT00722436 Craniosynostosis|Bleeding Drug: Tranexamic acid|Drug: saline University of Pittsburgh Phase 4 2008-07-01 2017-02-10
    NCT01111669 Chronic Rhinosinusitis With Polyposis|Chronic Hyperplastic Sinusitis Drug: Tranexamic Acid|Drug: Normal Saline (placebo) University of Alberta 2009-08-01 2012-04-25
    NCT00588133 Cardiac Surgery Drug: tranexamic acid|Drug: tranexamic acid Mayo Clinic Phase 3 2004-01-01 2009-11-09
    NCT01190150 Menorrhagia Drug: tranexamic acid Ferring Pharmaceuticals Phase 4 2010-08-01 2012-07-10
    NCT01535781 Hip Fracture|Anemia Drug: Tranexamic Acid|Drug: Placebo Hvidovre University Hospital 2011-09-01 2015-02-03
    NCT03037515 Blood Loss, Surgical|Blood Loss Anemia Drug: Tranexamic Acid Henry Ford Health System Phase 4 2017-02-15 2017-01-27
    NCT01594671 Blood Loss Drug: Tranexamic Acid|Drug: Tranexamic Acid|Other: haemostasia Fundaci贸 Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau Phase 3 2012-02-01 2012-12-18
    NCT01940536 Hip Fracture|Blood Loss Drug: Tranexamic Acid Hospital for Special Surgery, New York Phase 4 2014-08-01 2015-07-02
    NCT00755209 Brain Injuries Drug: tranexamic acid Khon Kaen University|Thailand Research Fund|Khon Kaen Hospital Phase 3 2008-10-01 2013-11-20
    NCT02918201 Postoperative Hemorrhage|Injuries and Wounds Drug: Tranexamic Acid|Drug: saline St. Olavs Hospital|Haukeland University Hospital Phase 4 2017-06-01 2017-03-06

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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