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Latrepirdine

丹吡芙蓉,Dimebon Dimebolin dihydrochloride

Latrepirdine是一种抗组织胺的药物。

目录号
EY1025
EY1025
EY1025
EY1025
纯度
99.17%
99.17%
99.17%
99.17%
规格
5 mg
10 mg
50 mg
100 mg
原价
720
890
2900
4920
售价
720
890
2900
4920
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
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  • 生物活性

    Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Zhang S, et al. J Alzheimers Dis, 2010, 21(2), 389-402.

    分子式
    C21H25N3.2HCl    		 分子量
    392.37    		 CAS号
    97657-92-6    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    20 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    10 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01085266 Huntington Disease Drug: Dimebon (latrepirdine) Medivation, Inc.|Pfizer Phase 3 2010-02-01 2016-10-11
    NCT00497159 Huntington's Disease Other: Placebo|Drug: Dimebon Medivation, Inc.|Huntington Study Group Phase 2 2007-07-01 2015-05-16
    NCT00920946 Huntington Disease Drug: Dimebon|Other: Placebo Medivation, Inc.|Pfizer Phase 3 2009-07-01 2016-10-11
    NCT00912288 Alzheimer Disease Drug: Dimebon 20 mg po TID|Drug: Placebo po TID Pfizer|Medivation, Inc. Phase 3 2009-09-01 2012-08-30
    NCT00829816 Alzheimer's Disease Drug: Dimebon|Drug: Placebo Medivation, Inc. Phase 1 2008-12-01 2015-11-06
    NCT00939783 Alzheimer's Disease Drug: Dimebon Pfizer|Medivation, Inc. Phase 3 2009-09-01 2012-10-11
    NCT00377715 Alzheimer's Disease Drug: Dimebon|Drug: Placebo Medivation, Inc. Phase 2 2005-09-01 2015-11-09
    NCT00675623 Alzheimer's Disease Drug: Dimebon|Drug: Dimebon|Drug: Placebo Medivation, Inc. Phase 3 2008-05-01 2016-09-24
    NCT00827034 Alzheimer's Disease|Huntington's Disease Drug: Warfarin|Drug: Dimebon|Drug: Warfarin Pfizer|Medivation, Inc. Phase 1 2009-02-01 2009-04-20
    NCT00954590 Moderate to Severe Alzheimer Drug: Dimebon (latrepirdine)|Drug: Placebo Medivation, Inc.|Pfizer Phase 3 2009-10-01 2016-09-24
    NCT00387270 Huntington's Disease Drug: Dimebon Medivation, Inc.|Huntington Study Group Phase 1|Phase 2 2006-10-01 2008-01-03
    NCT00704782 Alzheimer's Disease Drug: dimebon Medivation, Inc. Phase 2 2008-04-01 2015-11-13
    NCT01066481 Alzheimer's Disease|Dementia|Dimebon|Investigational Drug Drug: PF-01913539 5 mg|Drug: PF-01913539 5 mg|Drug: Placebo Pfizer Phase 2 2010-04-01 2010-06-28
    NCT00990613 Alzheimer's Disease|Huntington's Disease Drug: Dimebon IR|Drug: Dimebon Transdermal|Drug: Dimebon Transdermal|Drug: Dimebon IR|Drug: Dimebon Transdermal Pfizer|Medivation, Inc. Phase 1 2009-10-01 2010-02-02
    NCT00931073 Alzheimer's Disease|Huntington's Disease Drug: Dimebon alone|Drug: Dimebon + Ketoconazole|Drug: Dimebon + Omeprazole Pfizer|Medivation, Inc. Phase 1 2009-07-01 2009-11-17
    NCT00824590 Alzheimer's Disease|Huntington's Disease Drug: Dimebon|Drug: Dimebon Pfizer|Medivation, Inc. Phase 1 2009-02-01 2009-12-29
    NCT00988624 Alzheimer's Disease|Huntington Disease Drug: Dimebon IR Tablet|Drug: Dimebon MR1|Drug: Dimebon MR2|Drug: Dimebon MR3|Drug: Dimebon MR4 Pfizer|Medivation, Inc. Phase 1 2009-10-01 2010-01-11
    NCT01066546 Alzheimer's Disease Drug: Dimebon tablet for oral administration Pfizer|Medivation, Inc. Phase 3 2010-04-01 2012-08-30
    NCT00831506 Alzheimer Disease|Huntington Disease Drug: digoxin|Drug: digoxin|Drug: dimebon Pfizer|Medivation, Inc. Phase 1 2009-02-01 2009-06-09
    NCT00831532 Hepatic Failure Drug: Dimebon|Drug: Dimebon|Drug: Dimebon|Drug: Dimebon Pfizer|Medivation, Inc. Phase 1 2009-02-01 2009-09-14

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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