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Foscarnet Sodium

膦甲酸钠,Phosphonoformate

Foscarnet Sodium通过非竞争性抑制dNTPs而抑制病毒RNA聚合酶，逆转录酶和DNA聚合酶。

目录号
EY1024
EY1024
纯度
99.44%
99.44%
规格
50 mg
100 mg
原价
475
780
售价
475
780
库存
现货
现货
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  • 生物活性

    Foscarnet Sodium inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    0-1.5 mM

  • 动物实验

    5 mM病毒接种48小时后开始，在12小时的时间间隔30μL Foscarnet Sodium局部滴旋，一共处理14天

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Oberg B. Pharmacol Ther, 1989, 40(2), 213-285.

    分子式
    CNa3O5P    		 分子量
    191.95    		 CAS号
    63585-09-1    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    8 mg/mL    		 Water
    3 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02151240 Herpes Zoster Drug: Foscarnet Sodium|Drug: Acyclovir Cttq|Peking University People's Hospital Phase 4 2014-05-01 2014-05-28
    NCT00002125 Cytomegalovirus Retinitis|HIV Infections Drug: Foscarnet sodium Astra USA|NIH AIDS Clinical Trials Information Service Phase 4 2005-06-23
    NCT00000136 HIV Infections|Cytomegalovirus Retinitis Drug: Foscarnet|Drug: Ganciclovir Johns Hopkins Bloomberg School of Public Health|National Eye Institute (NEI)|Johns Hopkins University|University of Wisconsin, Madison|Baylor College of Medicine|Louisiana State University Health Sciences Center in New Orleans|New York Presbyterian Hospital|Icahn School of Medicine at Mount Sinai|New York University School of Medicine|Northwestern University|University of California, Los Angeles|University of California, San Diego|University of California, San Francisco|University of Miami|University of Massachusetts, Worcester|Memorial Sloan Kettering Cancer Center Phase 3 1990-03-01 2015-09-22
    NCT00002039 Cytomegalovirus Retinitis|HIV Infections Drug: Foscarnet sodium Astra USA|NIH AIDS Clinical Trials Information Service 2005-06-23
    NCT00002272 Herpes Simplex|HIV Infections Drug: Foscarnet sodium Astra USA|NIH AIDS Clinical Trials Information Service 2005-06-23
    NCT00002144 Herpes Simplex|HIV Infections Drug: Foscarnet sodium Astra USA|NIH AIDS Clinical Trials Information Service Phase 1 2005-06-23
    NCT00002432 Cytomegalovirus Retinitis|HIV Infections Drug: Foscarnet sodium Astra USA|NIH AIDS Clinical Trials Information Service 2005-06-23
    NCT00000726 Cytomegalovirus Retinitis|HIV Infections Drug: Foscarnet sodium National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 2012-03-28
    NCT00002145 HIV Infections|Gastrointestinal Diseases Drug: Foscarnet sodium Astra USA|NIH AIDS Clinical Trials Information Service Phase 3 2005-06-23
    NCT00002301 Cytomegalovirus Retinitis|HIV Infections Drug: Foscarnet sodium Astra USA|NIH AIDS Clinical Trials Information Service 2005-06-23
    NCT00000729 HIV Infections Drug: Foscarnet sodium National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 2012-03-28
    NCT00002021 Herpes Simplex|HIV Infections Drug: Foscarnet sodium Astra USA|NIH AIDS Clinical Trials Information Service 2005-06-23
    NCT00000697 Cytomegalovirus Retinitis|HIV Infections Drug: Foscarnet sodium National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 2012-05-29
    NCT00000691 Cytomegalovirus Retinitis|HIV Infections Drug: Foscarnet sodium National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 2012-03-28
    NCT00001002 HIV Infections Drug: Zidovudine|Drug: Foscarnet sodium National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 2012-03-28
    NCT00002146 Cytomegalovirus Infections|HIV Infections|Hypocalcemia Drug: Magnesium sulfate|Drug: Foscarnet sodium Astra USA|NIH AIDS Clinical Trials Information Service Phase 4 2005-06-23
    NCT00000665 Cytomegalovirus Retinitis|HIV Infections Drug: Foscarnet sodium|Drug: Ganciclovir National Institute of Allergy and Infectious Diseases (NIAID)|Johns Hopkins University 2011-03-11
    NCT00000856 Encephalopathy|HIV Infections|Radiculitis Drug: Foscarnet sodium|Drug: Ganciclovir National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 2012-05-29
    NCT00000970 Cytomegalovirus Retinitis|HIV Infections Drug: Foscarnet sodium|Drug: Ganciclovir National Institute of Allergy and Infectious Diseases (NIAID)|Astra USA|Hoffmann-La Roche Phase 1 2012-03-29
    NCT00000964 HIV Infections Drug: Ranitidine hydrochloride|Drug: Foscarnet sodium National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 2012-03-28

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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