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Moxonidine

莫索尼啶,BDF5895,Physiotens,BDF 5895,BDF-5895,

Moxonidine是咪唑啉1型受体(I1-R)选择性激动剂,为降压剂。

目录号
EY1014
EY1014
纯度
99.21%
99.21%
规格
50 mg
100 mg
原价
220
380
售价
220
380
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Moxonidine is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] H Aceros et. Al. British journal of pharmacology and chemotherapy, 164(3), 946-957 (2011).
    [2] V V Ruksin et. Al. Meditsina truda i promyshlennaia ekologiia, (5), 7-11 (2013).

    分子式
    C9H12ClN5O
    分子量
    241.68
    CAS号
    75438-57-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    22 mg/mL
    Water
    <1 mg/mL
    Ethanol
    2 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01180231 Obesity|Overweight Drug: Moxonidine (Physiotens)|Other: Dietary intervention Baker IDI Heart and Diabetes Institute Phase 4 2010-09-01 2013-11-03
    NCT00244504 Cardiac Disease|Vascular Surgery Drug: moxonidine University Hospital, Basel, Switzerland Phase 3 2002-11-01 2009-11-09
    NCT02355821 Osteopenia|Arterial Hypertension Drug: Moxonidine|Drug: Bisoprolol National Research Center for Preventive Medicine 2015-04-01 2016-09-20
    NCT00160277 Hypertension Drug: Moxonidine Solvay Pharmaceuticals Phase 3 2005-07-01 2009-01-29
    NCT01360710 Abdominal Obesity|Hypertension Drug: Moxonidine|Drug: Irbesartan Baker IDI Heart and Diabetes Institute Phase 4 2012-01-01 2012-02-01
    NCT01791699 Atrial Fibrillation Drug: Moxonidine|Drug: Placebo Spyridon Deftereos|G.Gennimatas General Hospital Phase 4 2012-08-01 2014-05-04
    NCT01094769 Diabetic Nephropathies Drug: Moxonidine|Drug: Placebo Baker IDI Heart and Diabetes Institute Phase 4 2011-04-01 2013-12-16
    NCT01567124 Schizophrenia Drug: Moxonidine|Drug: Placebo|Drug: Moxonidine|Drug: Placebo Baker IDI Heart and Diabetes Institute|The Alfred|Monash Medical Centre|Ballarat Health Services Phase 4 2012-05-01 2013-12-16
    NCT01504321 Polycystic Ovary Syndrome Drug: Moxonidine|Drug: Placebo Baker IDI Heart and Diabetes Institute Phase 4 2012-05-01 2016-01-11
    NCT01138423 Hypertension|Abdominal Obesity|Metabolic Syndrome Drug: Aliskiren|Drug: Moxonidine|Drug: Hydrochlorothiazide|Drug: Placebo (for aliskiren)|Drug: Placebo (for moxonidine and hydrochlorothiazide) UMC Utrecht|Novartis Pharmaceuticals Phase 4 2010-08-01 2012-02-23
    NCT00160160 Hypertension|Type 2 Diabetes Drug: eprosartan/HCTZ Solvay Pharmaceuticals 2004-10-01 2009-01-29
    NCT00518479 Hypertension|Left Ventricular Hypertrophy Drug: Bendroflumethiazide 2.5mg OD; Amlodipine 10mg OD|Drug: Valsartan 160mg OD; Moxonidine 400mcg OD University of Leeds|The Leeds Teaching Hospitals NHS Trust 2003-09-01 2012-08-15
    NCT00424801 Microvascular Angina|Hypertension Drug: Lercanidipine|Drug: Valsartan|Drug: Nicorandil|Drug: Doxazosin|Drug: Moxonidin|Drug: Pindolol|Drug: Amiloride, hydrochlorothiazide University of Aarhus|Danish Cardiovascular Research Academy|Danish Heart Foundation|Novartis 2007-01-01 2009-05-05
    NCT02734290 Triple Negative Breast Cancer Drug: Pembrolizumab|Drug: Paclitaxel|Drug: Capecitabine Providence Health & Services|Merck Sharp & Dohme Corp. Phase 1|Phase 2 2016-05-01 2016-07-27
    NCT02950259 Breast Neoplasm|Breast Neoplasm, Male Drug: Cyclophosphamide|Drug: Indomethacin|Drug: Omeprazole|Dietary Supplement: Multivitamin Providence Health & Services|IRX Therapeutics Phase 1 2017-02-09 2017-03-01
    NCT01862900 Metastatic Breast Cancer|Lung Metastases|Liver Metastases Biological: MEDI6469 Providence Health & Services|Robert W. Franz Cancer Center|Providence Cancer Center|Providence Cancer Center, Earle A. Chiles Research Institute|MedImmune LLC Phase 1|Phase 2 2013-02-01 2016-06-23
    NCT02614794 HER2 Positive Breast Cancer Drug: Tucatinib|Drug: Capecitabine|Drug: Trastuzumab|Drug: Placebo Cascadian Therapeutics Inc. Phase 2 2015-12-01 2016-12-23
    NCT02037529 Metastatic Breast Cancer|Locally Recurrent Breast Cancer Drug: Eribulin|Drug: Paclitaxel Academic and Community Cancer Research United Phase 3 2014-03-01 2017-03-15

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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