Amphotericin B是抗真菌类抗生素,由结节链霉菌中的一种菌株产生,IC50为0.028到0.290 μg/ml。
Amphotericin B (AmB) is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Sau K, et al. J Biol Chem, 2003, 278(39), 37561-37568.
分子式 C47H73NO17 |
分子量 924.08 |
CAS号 1397-89-3 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 22 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01615809 | Invasive Pulmonary Aspergillosis|Lymphoblastic Leukaemia|Myeloblastic Leukaemia|Lymphoblastic Leukemia|Myeloblastic Leukemia | Drug: MPHOTERICIN B | Fundaci Sant Joan de Du|Ministry of Health, Spain | Phase 2 | 2011-10-01 | 2015-11-04 |
NCT00876824 | Leishmaniasis, Visceral | Drug: Amphotericin B Lipid emulsion|Drug: Liposomal Amphotericin B | Bharat Serums and Vaccines Limited|Ministry of Science and Technology | Phase 3 | 2009-07-01 | 2011-06-01 |
NCT00628719 | Visceral Leishmaniasis | Drug: Liposomal Amphotericin B|Drug: amphotericin B deoxycholate | Banaras Hindu University | Phase 3 | 2008-02-01 | 2009-04-02 |
NCT02283905 | Blastomycosis | Drug: amphotericin-B|Drug: voriconazole | University of Manitoba|Pfizer | Phase 4 | 2015-06-01 | 2016-08-31 |
NCT02025491 | Disseminated Leishmaniasis | Drug: Liposomal Amphotericin B | Hospital Universitrio Professor Edgard Santos | Phase 3 | 2011-04-01 | 2013-12-30 |
NCT00371995 | Visceral Leishmaniasis | Drug: Liposomal amphotericin B and Miltefosine | Banaras Hindu University|Rajendra Memorial Research Institute of Medical Sciences | Phase 2 | 2007-10-01 | 2011-06-21 |
NCT01303549 | Liver Disease|Fungal Infection | Drug: Anidulafungin|Drug: Liposomal amphotericin B | Fundacion SEIMC-GESIDA|Pfizer | Phase 4 | 2011-11-01 | 2014-05-29 |
NCT00467883 | Zygomycosis | Drug: Liposomal Amphotericin B | Assistance Publique - Hpitaux de Paris | Phase 2 | 2007-06-01 | 2014-07-17 |
NCT00177684 | Lung Transplantation|Fungal Infections | Drug: Amphotericin B | University of Pittsburgh|Enzon Pharmaceuticals, Inc. | Phase 3 | 2004-09-01 | 2008-12-16 |
NCT02656797 | Leishmaniasis | Drug: Topical Amphotericin-B 0.4% liposomal gel | Soroka University Medical Center | Phase 2 | 2017-02-01 | 2016-10-13 |
NCT00425620 | Chronic Sinusitis | Drug: SinuNase | Accentia Biopharmaceuticals | Phase 3 | 2006-12-01 | 2007-11-29 |
NCT01032187 | Visceral Leishmaniasis | Drug: Meglumine antimoniate|Drug: Amphotericin B-deoxycholate | University of Brasilia|Ministry of Health, Brazil | Phase 4 | 2007-10-01 | 2011-03-07 |
NCT00177710 | Lung Transplantation|Fungal Infections | Drug: Amphotericin B | University of Pittsburgh|Astellas Pharma US, Inc. | Phase 3 | 2006-01-01 | 2008-12-16 |
NCT02136030 | Cryptococcal Meningitis | Drug: Liposomal amphotericin B|Drug: Amphotericin B-deoxycholate | TTY Biopharm | 2011-02-01 | 2014-05-08 | |
NCT01652859 | Normal Healthy Subjects | Drug: Liposomal Amphotericin B|Drug: AmBisome | Taiwan Liposome Company | Phase 1 | 2012-02-01 | 2013-11-25 |
NCT02629419 | Candidiasis, Chronic Mucocutaneous | Drug: Amphotericin B | Matinas BioPharma Nanotechnologies, Inc. | Phase 2 | 2015-11-01 | 2017-03-10 |
NCT00148148 | Hematopoietic Stem Cell Transplantation|Fungus Diseases | Drug: caspofungin|Drug: liposomal amphotericin B | University Hospital Muenster|Merck Sharp & Dohme Corp.|Gilead Sciences | Phase 2 | 2004-05-01 | 2008-01-09 |
NCT00815516 | Candidiasis | Drug: micafungin|Drug: amphotericin B deoxycholate | Astellas Pharma Global Development, Inc.|Astellas Pharma Inc | Phase 3 | 2013-02-01 | 2015-10-12 |
NCT01845727 | Cutaneous Leishmaniasis | Drug: Topical Amphotericin B at 3% | Drugs for Neglected Diseases | Phase 1|Phase 2 | 2014-02-01 | 2016-07-25 |
NCT01259713 | Invasive Fungal Disease | Drug: Liposomal amphotericin B|Drug: Placebo | Gilead Sciences | Phase 3 | 2011-04-01 | 2015-04-17 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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