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Amphotericin B

两性霉素 B,NSC-527017,Fungizone,Fungilin,AmBisome

Amphotericin B是抗真菌类抗生素,由结节链霉菌中的一种菌株产生,IC50为0.028到0.290 μg/ml。

目录号
EY1009
EY1009
EY1009
纯度
99.64%
99.64%
99.64%
规格
100 mg
500 mg
1 g
原价
466
920
1500
售价
466
920
1500
库存
现货
现货
现货
订购
订购
订购
订购
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  • 生物活性

    Amphotericin B (AmB) is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Sau K, et al. J Biol Chem, 2003, 278(39), 37561-37568.

    分子式
    C47H73NO17
    分子量
    924.08
    CAS号
    1397-89-3
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    22 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01615809 Invasive Pulmonary Aspergillosis|Lymphoblastic Leukaemia|Myeloblastic Leukaemia|Lymphoblastic Leukemia|Myeloblastic Leukemia Drug: MPHOTERICIN B Fundaci Sant Joan de Du|Ministry of Health, Spain Phase 2 2011-10-01 2015-11-04
    NCT00876824 Leishmaniasis, Visceral Drug: Amphotericin B Lipid emulsion|Drug: Liposomal Amphotericin B Bharat Serums and Vaccines Limited|Ministry of Science and Technology Phase 3 2009-07-01 2011-06-01
    NCT00628719 Visceral Leishmaniasis Drug: Liposomal Amphotericin B|Drug: amphotericin B deoxycholate Banaras Hindu University Phase 3 2008-02-01 2009-04-02
    NCT02283905 Blastomycosis Drug: amphotericin-B|Drug: voriconazole University of Manitoba|Pfizer Phase 4 2015-06-01 2016-08-31
    NCT02025491 Disseminated Leishmaniasis Drug: Liposomal Amphotericin B Hospital Universitrio Professor Edgard Santos Phase 3 2011-04-01 2013-12-30
    NCT00371995 Visceral Leishmaniasis Drug: Liposomal amphotericin B and Miltefosine Banaras Hindu University|Rajendra Memorial Research Institute of Medical Sciences Phase 2 2007-10-01 2011-06-21
    NCT01303549 Liver Disease|Fungal Infection Drug: Anidulafungin|Drug: Liposomal amphotericin B Fundacion SEIMC-GESIDA|Pfizer Phase 4 2011-11-01 2014-05-29
    NCT00467883 Zygomycosis Drug: Liposomal Amphotericin B Assistance Publique - Hpitaux de Paris Phase 2 2007-06-01 2014-07-17
    NCT00177684 Lung Transplantation|Fungal Infections Drug: Amphotericin B University of Pittsburgh|Enzon Pharmaceuticals, Inc. Phase 3 2004-09-01 2008-12-16
    NCT02656797 Leishmaniasis Drug: Topical Amphotericin-B 0.4% liposomal gel Soroka University Medical Center Phase 2 2017-02-01 2016-10-13
    NCT00425620 Chronic Sinusitis Drug: SinuNase Accentia Biopharmaceuticals Phase 3 2006-12-01 2007-11-29
    NCT01032187 Visceral Leishmaniasis Drug: Meglumine antimoniate|Drug: Amphotericin B-deoxycholate University of Brasilia|Ministry of Health, Brazil Phase 4 2007-10-01 2011-03-07
    NCT00177710 Lung Transplantation|Fungal Infections Drug: Amphotericin B University of Pittsburgh|Astellas Pharma US, Inc. Phase 3 2006-01-01 2008-12-16
    NCT02136030 Cryptococcal Meningitis Drug: Liposomal amphotericin B|Drug: Amphotericin B-deoxycholate TTY Biopharm 2011-02-01 2014-05-08
    NCT01652859 Normal Healthy Subjects Drug: Liposomal Amphotericin B|Drug: AmBisome Taiwan Liposome Company Phase 1 2012-02-01 2013-11-25
    NCT02629419 Candidiasis, Chronic Mucocutaneous Drug: Amphotericin B Matinas BioPharma Nanotechnologies, Inc. Phase 2 2015-11-01 2017-03-10
    NCT00148148 Hematopoietic Stem Cell Transplantation|Fungus Diseases Drug: caspofungin|Drug: liposomal amphotericin B University Hospital Muenster|Merck Sharp & Dohme Corp.|Gilead Sciences Phase 2 2004-05-01 2008-01-09
    NCT00815516 Candidiasis Drug: micafungin|Drug: amphotericin B deoxycholate Astellas Pharma Global Development, Inc.|Astellas Pharma Inc Phase 3 2013-02-01 2015-10-12
    NCT01845727 Cutaneous Leishmaniasis Drug: Topical Amphotericin B at 3% Drugs for Neglected Diseases Phase 1|Phase 2 2014-02-01 2016-07-25
    NCT01259713 Invasive Fungal Disease Drug: Liposomal amphotericin B|Drug: Placebo Gilead Sciences Phase 3 2011-04-01 2015-04-17

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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