Dutasteride是5α还原酶同工酶抑制剂,还可能因其结构域DHT相似对雄激素受体(AR)产生脱靶效应。
Dutasteride is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Frye SV, et al. Curr Top Med Chem, 2006, 6(5), 405-421.
分子式 C27H30F6N2O2 |
分子量 528.53 |
CAS号 164656-23-9 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 64 mg/mL |
Water <1 mg/mL |
Ethanol 6 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00802321 | Alcohol Related Disorders|Alcoholism|Alcohol Abuse | Drug: Dutasteride | UConn Health|National Institutes of Health (NIH)|National Institute on Alcohol Abuse and Alcoholism (NIAAA) | 2006-04-01 | 2010-09-22 | |
NCT01004809 | Alopecia | Drug: Dutasteride | GlaxoSmithKline | 2010-04-01 | 2014-07-31 | |
NCT00985738 | Prostate Cancer | Drug: Dutasteride|Other: Placebo | University of Colorado, Denver|GlaxoSmithKline | Phase 2 | 2009-09-01 | 2016-04-15 |
NCT00706966 | Nonmalignant Neoplasm|Prostate Cancer | Drug: dutasteride | University of California, San Francisco | 2005-06-01 | 2013-12-02 | |
NCT01525914 | Prostate Cancer | Drug: Dutasteride | Sunnybrook Health Sciences Centre|Toronto Sunnybrook Regional Cancer Centre | 2010-05-01 | 2012-02-02 | |
NCT00805701 | Prostate Cancer | Drug: avodart|Drug: Placebo | Bay State Clinical Trials, Inc.|GlaxoSmithKline | Phase 4 | 2009-01-01 | 2014-05-12 |
NCT01957189 | Prostatic Hyperplasia | Drug: Dutasteride and Tamsulosin | GlaxoSmithKline | Phase 1 | 2013-10-01 | 2017-01-16 |
NCT00382356 | Benign Prostatic Hypertrophy | Drug: Dutasteride | North Florida/South Georgia Veterans Health System | 2004-11-01 | 2012-10-18 | |
NCT01262287 | Alcoholism|Alcohol Abuse|Alcohol Dependence | Drug: Dutasteride|Drug: Placebo | UConn Health|National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Phase 4 | 2011-01-01 | 2017-02-09 |
NCT02578953 | Prostatic Hyperplasia | Drug: Dutasteride-Test product|Drug: Dutasteride-Reference product | GlaxoSmithKline | Phase 1 | 2015-09-01 | 2017-01-25 |
NCT00441116 | Alopecia|Androgenetic Alopecia | Drug: Dutasteride 0.5mg oral tablets | GlaxoSmithKline | Phase 3 | 2006-12-01 | 2011-08-11 |
NCT00303446 | Kennedy's Disease|Spinal and Bulbar Muscular Atrophy | Drug: Dutasteride|Drug: Placebo | National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) | Phase 2 | 2006-03-01 | 2011-01-25 |
NCT01254071 | Prostatic Hyperplasia | Drug: Dutasteride (0.5mg); Tamsulosin hydrochloride (0.2mg); fixed dose combination product of duatsteride (0.5mg) and tamsulosin hydrochloride (0.2mg) | GlaxoSmithKline | Phase 1 | 2010-09-01 | 2016-11-30 |
NCT00363311 | Neoplasms, Prostate | Drug: Dutasteride|Drug: Matching placebo | GlaxoSmithKline | Phase 4 | 2006-07-01 | 2016-11-30 |
NCT00553878 | Prostate Cancer | Drug: Dutasteride | Canadian Urology Research Consortium|GlaxoSmithKline | Phase 2|Phase 3 | 2007-03-01 | 2016-10-13 |
NCT00853697 | Prostate Cancer|Castration-resistant, Metastatic | Other: testosterone (AndroGel) with the 5-reductase inhibitor dutasteride | Memorial Sloan Kettering Cancer Center|GlaxoSmithKline|University of Washington | Phase 2 | 2009-03-01 | 2015-10-28 |
NCT00673127 | Prostate Cancer | Drug: Ketoconazole, Hydrocortisone and Dutasteride | Beth Israel Deaconess Medical Center|Massachusetts General Hospital|Dana-Farber Cancer Institute|Sunnybrook Health Sciences Centre|Oregon Health and Science University|M.D. Anderson Cancer Center|Sidney Kimmel Comprehensive Cancer Center | Phase 2 | 2005-02-01 | 2015-04-20 |
NCT01471678 | Prostatic Hyperplasia | Drug: Dutasteride (0.5mg)|Drug: FDC product of dutasteride (0.5mg) and tamsulosin HCl (0.2mg)|Drug: Harnal D Tablets and Harnal Capsules (both comprising 0.2 mg tamsulosin HCl) | GlaxoSmithKline | Phase 1 | 2011-06-01 | 2016-11-30 |
NCT01831791 | Alopecia | Drug: Dutasteride 0.5 mg | GlaxoSmithKline | Phase 3 | 2013-04-01 | 2015-02-26 |
NCT00194675 | Hypogonadism|Benign Prostatic Hyperplasia | Drug: Dutasteride|Drug: Testosterone gel|Drug: Placebo dutasteride | University of Washington|GlaxoSmithKline|Seattle Institute for Biomedical and Clinical Research|VA Office of Research and Development|Solvay Pharmaceuticals | Phase 4 | 2005-03-01 | 2012-07-16 |
NCT00827814 | Benign Prostatic Hyperplasia | Drug: Dutasteride | Samsung Medical Center|GlaxoSmithKline | Phase 4 | 2006-06-01 | 2009-06-08 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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