Dutasteride

度他雄胺,GI-198745,GG-745,Avodart,Avolve,GG745,GG 745,GI198745

Dutasteride是5α还原酶同工酶抑制剂,还可能因其结构域DHT相似对雄激素受体(AR)产生脱靶效应。

目录号
EY1006
EY1006
EY1006
纯度
99.25%
99.25%
99.25%
规格
5 mg
10 mg
50 mg
原价
532
840
2530
售价
532
840
2530
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Dutasteride is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Frye SV, et al. Curr Top Med Chem, 2006, 6(5), 405-421.

    分子式
    C27H30F6N2O2
    分子量
    528.53
    CAS号
    164656-23-9
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    64 mg/mL
    Water
    <1 mg/mL
    Ethanol
    6 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00802321 Alcohol Related Disorders|Alcoholism|Alcohol Abuse Drug: Dutasteride UConn Health|National Institutes of Health (NIH)|National Institute on Alcohol Abuse and Alcoholism (NIAAA) 2006-04-01 2010-09-22
    NCT01004809 Alopecia Drug: Dutasteride GlaxoSmithKline 2010-04-01 2014-07-31
    NCT00985738 Prostate Cancer Drug: Dutasteride|Other: Placebo University of Colorado, Denver|GlaxoSmithKline Phase 2 2009-09-01 2016-04-15
    NCT00706966 Nonmalignant Neoplasm|Prostate Cancer Drug: dutasteride University of California, San Francisco 2005-06-01 2013-12-02
    NCT01525914 Prostate Cancer Drug: Dutasteride Sunnybrook Health Sciences Centre|Toronto Sunnybrook Regional Cancer Centre 2010-05-01 2012-02-02
    NCT00805701 Prostate Cancer Drug: avodart|Drug: Placebo Bay State Clinical Trials, Inc.|GlaxoSmithKline Phase 4 2009-01-01 2014-05-12
    NCT01957189 Prostatic Hyperplasia Drug: Dutasteride and Tamsulosin GlaxoSmithKline Phase 1 2013-10-01 2017-01-16
    NCT00382356 Benign Prostatic Hypertrophy Drug: Dutasteride North Florida/South Georgia Veterans Health System 2004-11-01 2012-10-18
    NCT01262287 Alcoholism|Alcohol Abuse|Alcohol Dependence Drug: Dutasteride|Drug: Placebo UConn Health|National Institute on Alcohol Abuse and Alcoholism (NIAAA) Phase 4 2011-01-01 2017-02-09
    NCT02578953 Prostatic Hyperplasia Drug: Dutasteride-Test product|Drug: Dutasteride-Reference product GlaxoSmithKline Phase 1 2015-09-01 2017-01-25
    NCT00441116 Alopecia|Androgenetic Alopecia Drug: Dutasteride 0.5mg oral tablets GlaxoSmithKline Phase 3 2006-12-01 2011-08-11
    NCT00303446 Kennedy's Disease|Spinal and Bulbar Muscular Atrophy Drug: Dutasteride|Drug: Placebo National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) Phase 2 2006-03-01 2011-01-25
    NCT01254071 Prostatic Hyperplasia Drug: Dutasteride (0.5mg); Tamsulosin hydrochloride (0.2mg); fixed dose combination product of duatsteride (0.5mg) and tamsulosin hydrochloride (0.2mg) GlaxoSmithKline Phase 1 2010-09-01 2016-11-30
    NCT00363311 Neoplasms, Prostate Drug: Dutasteride|Drug: Matching placebo GlaxoSmithKline Phase 4 2006-07-01 2016-11-30
    NCT00553878 Prostate Cancer Drug: Dutasteride Canadian Urology Research Consortium|GlaxoSmithKline Phase 2|Phase 3 2007-03-01 2016-10-13
    NCT00853697 Prostate Cancer|Castration-resistant, Metastatic Other: testosterone (AndroGel) with the 5-reductase inhibitor dutasteride Memorial Sloan Kettering Cancer Center|GlaxoSmithKline|University of Washington Phase 2 2009-03-01 2015-10-28
    NCT00673127 Prostate Cancer Drug: Ketoconazole, Hydrocortisone and Dutasteride Beth Israel Deaconess Medical Center|Massachusetts General Hospital|Dana-Farber Cancer Institute|Sunnybrook Health Sciences Centre|Oregon Health and Science University|M.D. Anderson Cancer Center|Sidney Kimmel Comprehensive Cancer Center Phase 2 2005-02-01 2015-04-20
    NCT01471678 Prostatic Hyperplasia Drug: Dutasteride (0.5mg)|Drug: FDC product of dutasteride (0.5mg) and tamsulosin HCl (0.2mg)|Drug: Harnal D Tablets and Harnal Capsules (both comprising 0.2 mg tamsulosin HCl) GlaxoSmithKline Phase 1 2011-06-01 2016-11-30
    NCT01831791 Alopecia Drug: Dutasteride 0.5 mg GlaxoSmithKline Phase 3 2013-04-01 2015-02-26
    NCT00194675 Hypogonadism|Benign Prostatic Hyperplasia Drug: Dutasteride|Drug: Testosterone gel|Drug: Placebo dutasteride University of Washington|GlaxoSmithKline|Seattle Institute for Biomedical and Clinical Research|VA Office of Research and Development|Solvay Pharmaceuticals Phase 4 2005-03-01 2012-07-16
    NCT00827814 Benign Prostatic Hyperplasia Drug: Dutasteride Samsung Medical Center|GlaxoSmithKline Phase 4 2006-06-01 2009-06-08

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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