Sildenafil citrate是磷酸二酯酶5(PDE-5)抑制剂,IC50为5.22 nM,可能是最好的可作用于勃起功能紊乱的化合物。
Sildenafil Citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), is a well-tolerated and highly effective treatment for erectile dysfunction.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Nehra A, et al. World J Urol, 2001, 19(1), 40-45.
分子式 C28H38N6O11S |
分子量 666.7 |
CAS号 171599-83-0 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 22 mg/mL |
Water 3 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00123162 | Dysmenorrhea | Drug: Sildenafil Citrate|Drug: Placebo | Milton S. Hershey Medical Center|National Institutes of Health (NIH) | Phase 1|Phase 2 | 2007-05-01 | 2015-11-18 |
NCT01321489 | Erectile Dysfunction | Drug: Sildenafil Citrate 20mg Tablet Sublingual|Drug: Viagra 50mg tablet Coated | Laboratrio Teuto Brasileiro S/A | Phase 3 | 2011-09-01 | 2011-03-22 |
NCT00781508 | Heart Failure|Left Ventricular Dysfunction | Drug: sildenafil|Other: Placebo | MetroHealth Medical Center|National Center for Research Resources (NCRR) | Phase 4 | 2006-12-01 | 2014-06-23 |
NCT01668446 | Endometrial Preparation|Frozen Embryo Transfer | Drug: Sildenafil|Drug: estradiol valerat | farzaneh hojjat|Razieh dehghani firouzabadi|Robab davar|Shahid Sadoughi University of Medical Sciences and Health Services | Phase 4 | 2009-09-01 | 2012-09-11 |
NCT01347008 | Scleroderma, Systemic|Scleroderma, Diffuse|Scleroderma, Limited|Raynaud Phenomenon | Drug: Sildenafil citrate|Drug: Placebo (Sugar pill) | Federal University of So Paulo|Fundao de Amparo Pesquisa do Estado de So Paulo | Phase 3 | 2011-04-01 | 2016-10-12 |
NCT01889966 | Pulmonary Hypertension Associated With Connective Tissue Disease | Drug: Sildenafil | Kerckhoff Heart Center|Pfizer | Phase 4 | 2013-04-01 | 2015-04-26 |
NCT02136329 | Acute Kidney Injury | Drug: Sildenafil | University of Leicester|British Heart Foundation | Phase 1 | 2013-06-01 | 2015-06-12 |
NCT00199563 | Impotence | Drug: Viagra | Lawson Health Research Institute | Phase 4 | 2004-08-01 | 2013-01-24 |
NCT02845388 | Infertility | Drug: Sildenafil citrate|Drug: estradiol valerate | Omar Ahmed El Sayed Saad|Ain Shams Maternity Hospital | Phase 2 | 2015-09-01 | 2016-07-26 |
NCT01247805 | Pulmonary Arterial Hypertention | Drug: sildenafil citrate|Drug: Sildenafil citrate|Drug: sildenafil citrate | Pfizer | Phase 1 | 2011-01-01 | 2011-02-10 |
NCT02466802 | Solid Tumor | Drug: Regorafenib|Drug: Sildenafil Citrate | Virginia Commonwealth University|Bayer | Phase 1 | 2015-07-01 | 2017-03-02 |
NCT01670136 | Persistent Pulmonary Hypertension of the Newborn | Drug: 1 dose of sildenafil | University of North Carolina, Chapel Hill|Duke University|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|The EMMES Corporation | Phase 1 | 2013-02-01 | 2016-11-01 |
NCT02372487 | Pregnancy Complication | Drug: sildenafil citrate|Dietary Supplement: fluid therapy | Al Hayat National Hospital|Menoufia University | 2015-03-01 | 2016-02-02 | |
NCT00165295 | Waldenstrom's Macroglobulinemia | Drug: Sildenafil citrate (Viagra) | Dana-Farber Cancer Institute|Beth Israel Deaconess Medical Center | Phase 2 | 2005-09-01 | 2011-06-23 |
NCT01365585 | Pulmonary Arterial Hypertension | Drug: sildenafil citrate | Pfizer | 2011-07-01 | 2013-01-08 | |
NCT01830790 | Age-related Macular Degeneration | Drug: Sildenafil citrate | Duke University | Phase 2 | 2013-03-01 | 2015-05-27 |
NCT00527995 | Type 2 Diabetes Mellitus|Endothelial Dysfunction | Drug: Sildenafil | Ruhr University of Bochum | Phase 3 | 2001-08-01 | 2007-09-10 |
NCT00454207 | Pulmonary Hypertension | Drug: sildenafil citrate (UK-92,480) | Pfizer | Phase 3 | 2007-04-01 | 2013-08-19 |
NCT01054001 | Prostate Cancer | Drug: sildenafil 100mg | Seoul National University Bundang Hospital|Pfizer | 2010-06-01 | 2011-08-18 | |
NCT01954524 | Cirrhosis | Drug: IV bolus injection of Sildenafil | University of Maryland | Phase 1 | 2014-05-01 | 2016-10-30 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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