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Teriflunomide

特立氟胺,A77 1726,HMR-1726,HMR 1726,HMR1726,A77-1726,A771726,(E/Z)-Teriflunomide (E/Z)-特立氟胺; (E/Z)-A77 1726

Teriflunomide是Leflunomide的活性代谢物,通过抑制酶二氢乳清酸脱氢酶,从而抑制嘧啶从头合成,作为一种免疫调节剂。

目录号
EY1003
EY1003
EY1003
EY1003
纯度
99.59%
99.59%
99.59%
99.59%
规格
5 mg
10 mg
50 mg
100 mg
原价
220
360
550
790
售价
220
360
550
790
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Teriflunomide is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] OJ H, et al. Ther Clin Risk Manag, 2013,9,177-190.

    分子式
    C12H9F3N2O2
    分子量
    270.21
    CAS号
    108605-62-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    20 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02263547 Teriflunomide Elimination|Healthy Volunteers Drug: teriflunomide|Drug: Colestipol Derrick Scott Robertson|Genzyme, a Sanofi Company|University of South Florida Phase 1 2015-01-01 2016-09-15
    NCT01970410 Multiple Sclerosis Drug: teriflunomide Multiple Sclerosis Center of Northeastern New York|Providence Multiple Sclerosis Center Phase 4 2013-10-01 2016-10-24
    NCT01895335 Multiple Sclerosis Drug: Teriflunomide Sanofi Phase 4 2013-06-01 2016-10-10
    NCT02490982 Relapsing Remitting Multiple Sclerosis Drug: Teriflunomide Centre hospitalier de l'Universit de Montral (CHUM)|Genzyme, a Sanofi Company|Montreal Neurological Institute and Hospital Phase 4 2015-07-01 2016-01-25
    NCT01487096 Multiple Sclerosis Drug: Teriflunomide|Drug: Placebo (placebo for teriflunomide) Sanofi Phase 2 2001-04-01 2012-10-03
    NCT00134563 Multiple Sclerosis Drug: Teriflunomide|Drug: Placebo (for teriflunomide) Sanofi Phase 3 2004-09-01 2013-01-02
    NCT00622700 Multiple Sclerosis Drug: Teriflunomide|Drug: Placebo Sanofi Phase 3 2008-02-01 2017-01-20
    NCT00489489 Multiple Sclerosis Drug: Teriflunomide|Drug: Placebo (for Teriflunomide)|Drug: Interferon-尾 Sanofi Phase 2 2007-05-01 2012-11-05
    NCT00475865 Multiple Sclerosis Drug: Teriflunomide|Drug: Placebo (for teriflunomide)|Drug: Glatiramer Acetate (GA) Sanofi Phase 2 2007-04-01 2012-11-05
    NCT02046629 Multiple Sclerosis Drug: Teriflunomide HMR1726|Drug: cholestyramine Sanofi Phase 1 2014-05-01 2014-08-20
    NCT00751881 Multiple Sclerosis Drug: Placebo|Drug: Teriflunomide Sanofi Phase 3 2008-08-01 2016-05-27
    NCT01252355 Multiple Sclerosis Relapse Drug: Teriflunomide|Drug: Placebo (for teriflunomide)|Drug: Interferon-beta (IFN-beta) Sanofi Phase 3 2011-01-01 2014-05-30
    NCT00803049 Multiple Sclerosis Drug: Teriflunomide (HMR1726) Sanofi Phase 3 2006-10-01 2016-12-05
    NCT02792218 Relapsing Multiple Sclerosis Drug: Ofatumumab subcutaneous injection|Drug: Placebo orally matching to teriflunomide|Drug: Teriflunomide orally|Drug: Placebo subcutanous injection matching to ofatumumab Novartis Pharmaceuticals|Novartis Phase 3 2016-09-19 2017-02-22
    NCT02792231 Relapsing Multiple Scelrosis Drug: Ofatumumab subcutaneous injection|Drug: Placebo orally matching to teriflunomide|Drug: Teriflunomide orally|Drug: Placebo subcutaneous injection matching to ofatumumab Novartis Pharmaceuticals|Novartis Phase 3 2016-08-26 2017-02-06
    NCT00883337 Multiple Sclerosis Drug: Interferon -1a|Drug: Teriflunomide Sanofi Phase 3 2009-04-01 2016-05-04
    NCT01403376 Multiple Sclerosis Drug: teriflunomide|Drug: Interferon--1|Biological: Influenza vaccine Sanofi Phase 2 2011-09-01 2016-01-21
    NCT00228163 Multiple Sclerosis Drug: teriflunomide (HMR1726) Sanofi Phase 2 2002-01-01 2015-03-24
    NCT02201108 Multiple Sclerosis Drug: Teriflunomide HMR1726|Drug: Placebo Genzyme, a Sanofi Company|Sanofi Phase 3 2014-07-01 2017-03-09
    NCT02587195 Multiple Sclerosis Drug: Teriflunomide Centre Hospitalier Universitaire de Nice Phase 3 2015-10-01 2015-10-23

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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