Trifluoperazine dihydrochloride (盐酸三氟拉嗪) 是多巴胺D2受体抑制剂,有抗精神病和止吐作用。
Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Lahti RA, et al. Eur J Pharmacol, 1993, 236(3), 483-486.
分子式 C21H26Cl2F3N3S |
分子量 480.42 |
CAS号 440-17-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 87 mg/mL |
Water 90 mg/mL |
Ethanol 90 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02704962 | Schizophrenia | Drug: full-dose olanzapine | Kaohsiung Kai-Suan Psychiatric Hospital|Department of Health, Executive Yuan, R.O.C. (Taiwan) | Phase 4 | 2012-01-01 | 2016-03-04 |
NCT01765829 | Psychosis Nos/Other | Drug: Discontinuation antipsychotic treatment|Drug: Antipsychotic treatment | Fundacin Pblica Andaluza Progreso y Salud|Instituto de Salud Carlos III|Andalusian Initiative for Advanced Therapies - Fundacin Pblica Andaluza Progreso y Salud | Phase 3 | 2012-11-01 | 2014-12-04 |
NCT02582736 | Psychotic Disorders|Schizophrenia|Schizoaffective Disorder|Bipolar Disorder|Diabetes Mellitus, Type 2 | Drug: Olanzapine|Drug: Risperidone|Drug: atypical antipsychotics (other)|Drug: typical antipsychotics | Canadian Network for Observational Drug Effect Studies, CNODES|Drug Safety and Effectiveness Network, Canada|Canadian Institutes of Health Research (CIHR) | 2012-04-01 | 2015-10-20 | |
NCT01231074 | Obesity|Weight Gain|Psychotropic Induced Weight Gain | Drug: Metformin | Nationwide Children's Hospital | Phase 1 | 2010-02-01 | 2010-10-29 |
NCT02600741 | Schizophrenia | Other: Caregiver psycho-education and skills training|Other: Caregiver support available at the study site|Drug: Paliperidone palmitate|Drug: Chlorpromazine|Drug: Droperidol|Drug: Fluphenazine|Drug: Haloperidol|Drug: Loxapine|Drug: Perphenazine|Drug: Pimozide|Drug: Prochlorperazine|Drug: Thiothixene|Drug: Thioridazine|Drug: Trifluoperazine|Drug: Aripiprazole|Drug: Asenapine|Drug: Clozapine|Drug: Iloperidone|Drug: Olanzapine|Drug: Paliperidone|Drug: Quetiapine|Drug: Risperidone|Drug: Ziprasidone | Janssen Scientific Affairs, LLC | 2015-07-24 | 2017-03-17 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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