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NAD+

NAD+即烟酰胺腺嘌呤二核苷酸,是一种转递氢离子的辅酶。

目录号
EY0995
EY0995
EY0995
纯度
99.33%
99.33%
99.33%
规格
500 mg
1 g
5 g
原价
470
620
920
售价
470
620
920
库存
现货
现货
现货
订购
订购
订购
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  • 生物活性

    NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Chu-Fang Chou et. Al. Journal of Biological Chemistry, 277(28), 25209-25216 (2002).
    [2] Jinrui Zhang et. Al. Scientific reports, 5, 12846 (2015).

    分子式
    C21H27N7O14P2
    分子量
    663.43
    CAS号
    53-84-9
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    <1 mg/mL
    Water
    200 mM
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02721537 Concussion, Mild Dietary Supplement: Nicotinamide Riboside|Other: Matching placebo Mayo Clinic|University of Minnesota - Clinical and Translational Science Institute|Thorne Research Inc. 2016-09-01 2017-03-23
    NCT02942888 Mild Cognitive Impairment|NAD Dietary Supplement: Nicotinamide riboside|Dietary Supplement: Sugar Pill The University of Texas Health Science Center at San Antonio|University of Texas|South Texas Veterans Health Care System 2016-10-01 2016-10-24
    NCT02950441 Aging Dietary Supplement: Nicotinamide Riboside|Other: Placebo University of Birmingham Early Phase 1 2016-06-01 2016-11-04
    NCT02063126 Chronic Fatigue Syndrome Dietary Supplement: ReConnect (NADH plus CoQ10)|Dietary Supplement: placebo Hospital Universitari Vall d'Hebron Research Institute|VITAE NATURAL NUTRITION, S.L. Phase 2|Phase 3 2013-01-01 2015-02-18
    NCT02010151 Out of Hospital Cardiac Arrest Other: NAD-CPR Seoul National University Hospital|Korean Center for Disease Control and Prevention|Seoul Metropolitan Government Health and Welfare Office|Seoul Metropolitan Fire and Disaster Headquater|Korea Association for Safety Community 2015-03-01 2017-02-14
    NCT02689882 Metabolic Disturbance Dietary Supplement: nicotinamide riboside University of Washington|National Heart, Lung, and Blood Institute (NHLBI) Phase 1 2015-11-01 2016-02-18
    NCT02921659 Aging Dietary Supplement: Niagen鈩Dietary Supplement: Placebo University of Colorado, Boulder|ChromaDex, Inc. Phase 1|Phase 2 2015-04-01 2016-11-29
    NCT02061267 Metabolic Syndrome Dietary Supplement: Niacin|Dietary Supplement: Saturated meal|Dietary Supplement: Monounsaturated meal|Dietary Supplement: Polyunsaturated meal National Research Council, Spain 2012-01-01 2014-02-19
    NCT00454948 Obesity Behavioral: Home-based nutrition sessions and play group exercise|Behavioral: Group-based nutrition sessions and mail-out activities Stanford University Phase 1 2007-03-01 2007-03-30
    NCT00888758 Coronary Heart Disease|Percutaneous Coronary Intervention Device: biolimus A9|Device: everolimus Masaryk University Phase 4 2009-05-01 2009-04-30
    NCT00465907 Lung Cancer Drug: Paclitaxel, Carboplatin, Irinotecan Sidney Kimmel Comprehensive Cancer Center Phase 2 2003-05-01 2008-12-16
    NCT01566799 Locally Advanced Malignant Neoplasm Drug: Metformin Instituto Nacional de Cancerologia de Mexico|Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Phase 2 2012-04-01 2012-03-29
    NCT02389660 Depression Behavioral: Blended Cognitive Behavioural Therapy (CBT)|Behavioral: Treatment as usual University of Social Sciences and Humanities, Warsaw|VU University of Amsterdam|Linkoeping University|University of Erlangen-Nrnberg|London School of Hygiene and Tropical Medicine|Stichting GGZ inGeest|Universitat Jaume I|Leuphana Universitt Lnenberg|University of Limerick|University of Bern|University of Valencia|Inesc Porto|Institut National de la Sant Et de la Recherche Mdicale, France|European Commission|Ministry of Science and Higher Education, Poland 2015-06-01 2017-01-04
    NCT02291159 Stroke|Spasticity Device: DNHS (Dry Needling for Hypertonia and Spasticity)|Device: Sham Dry Needling Universidad San Jorge 2014-11-01 2014-12-30
    NCT02064569 Leber Hereditary Optic Neuropathy Genetic: GS010 GenSight Biologics Phase 1|Phase 2 2014-02-01 2017-02-22
    NCT02619539 Trauma, Multiple Procedure: plasma fibrinogen measurement Masaryk Hospital Krajsk zdravotn a.s. 2016-01-01 2017-03-22
    NCT01608126 Cervical Plexus Block Comparison Procedure: cervical block Daniel Nalos MD|Masaryk Hospital Krajsk zdravotn a.s. 2011-01-01 2012-05-29
    NCT01508091 Obesity Behavioral: energy restricted mediterranean-type diet|Behavioral: 25 % calorie restriction University of Chile 2012-05-01 2012-10-20
    NCT02513693 Neuromuscular Blockade Drug: Standard neuromuscular blockade|Drug: Deep neuromuscular blockade Palacky University|University Hospital Olomouc|Masaryk Hospital, Usti nad Labem Phase 4 2015-07-01 2015-07-30
    NCT03030586 Alzheimer Disease|Frontotemporal Lobar Degeneration|Lewy Body Disease|Parkinson Disease Dementia|Progressive Supranuclear Palsy|Corticobasal Degeneration Amoneta Diagnostics SAS|European Commission|Firalis SA|University Hospital, Strasbourg|Centre Hospitalier Universitaire Vaudois|IRCCS Centro San Giovanni di Dio Fatebenefratelli|H么pitaux Civils de Colmar|Istanbul University|Assistance Publique - H么pitaux de Paris|University Hospital, Lille|University Hospital, Geneva|Cliniques universitaires Saint-Luc- Universit Catholique de Louvain 2016-11-01 2017-03-02

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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