NAD+即烟酰胺腺嘌呤二核苷酸,是一种转递氢离子的辅酶。
NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Chu-Fang Chou et. Al. Journal of Biological Chemistry, 277(28), 25209-25216 (2002).
[2] Jinrui Zhang et. Al. Scientific reports, 5, 12846 (2015).
分子式 C21H27N7O14P2 |
分子量 663.43 |
CAS号 53-84-9 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO <1 mg/mL |
Water 200 mM |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02721537 | Concussion, Mild | Dietary Supplement: Nicotinamide Riboside|Other: Matching placebo | Mayo Clinic|University of Minnesota - Clinical and Translational Science Institute|Thorne Research Inc. | 2016-09-01 | 2017-03-23 | |
NCT02942888 | Mild Cognitive Impairment|NAD | Dietary Supplement: Nicotinamide riboside|Dietary Supplement: Sugar Pill | The University of Texas Health Science Center at San Antonio|University of Texas|South Texas Veterans Health Care System | 2016-10-01 | 2016-10-24 | |
NCT02950441 | Aging | Dietary Supplement: Nicotinamide Riboside|Other: Placebo | University of Birmingham | Early Phase 1 | 2016-06-01 | 2016-11-04 |
NCT02063126 | Chronic Fatigue Syndrome | Dietary Supplement: ReConnect (NADH plus CoQ10)|Dietary Supplement: placebo | Hospital Universitari Vall d'Hebron Research Institute|VITAE NATURAL NUTRITION, S.L. | Phase 2|Phase 3 | 2013-01-01 | 2015-02-18 |
NCT02010151 | Out of Hospital Cardiac Arrest | Other: NAD-CPR | Seoul National University Hospital|Korean Center for Disease Control and Prevention|Seoul Metropolitan Government Health and Welfare Office|Seoul Metropolitan Fire and Disaster Headquater|Korea Association for Safety Community | 2015-03-01 | 2017-02-14 | |
NCT02689882 | Metabolic Disturbance | Dietary Supplement: nicotinamide riboside | University of Washington|National Heart, Lung, and Blood Institute (NHLBI) | Phase 1 | 2015-11-01 | 2016-02-18 |
NCT02921659 | Aging | Dietary Supplement: Niagen鈩Dietary Supplement: Placebo | University of Colorado, Boulder|ChromaDex, Inc. | Phase 1|Phase 2 | 2015-04-01 | 2016-11-29 |
NCT02061267 | Metabolic Syndrome | Dietary Supplement: Niacin|Dietary Supplement: Saturated meal|Dietary Supplement: Monounsaturated meal|Dietary Supplement: Polyunsaturated meal | National Research Council, Spain | 2012-01-01 | 2014-02-19 | |
NCT00454948 | Obesity | Behavioral: Home-based nutrition sessions and play group exercise|Behavioral: Group-based nutrition sessions and mail-out activities | Stanford University | Phase 1 | 2007-03-01 | 2007-03-30 |
NCT00888758 | Coronary Heart Disease|Percutaneous Coronary Intervention | Device: biolimus A9|Device: everolimus | Masaryk University | Phase 4 | 2009-05-01 | 2009-04-30 |
NCT00465907 | Lung Cancer | Drug: Paclitaxel, Carboplatin, Irinotecan | Sidney Kimmel Comprehensive Cancer Center | Phase 2 | 2003-05-01 | 2008-12-16 |
NCT01566799 | Locally Advanced Malignant Neoplasm | Drug: Metformin | Instituto Nacional de Cancerologia de Mexico|Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | Phase 2 | 2012-04-01 | 2012-03-29 |
NCT02389660 | Depression | Behavioral: Blended Cognitive Behavioural Therapy (CBT)|Behavioral: Treatment as usual | University of Social Sciences and Humanities, Warsaw|VU University of Amsterdam|Linkoeping University|University of Erlangen-Nrnberg|London School of Hygiene and Tropical Medicine|Stichting GGZ inGeest|Universitat Jaume I|Leuphana Universitt Lnenberg|University of Limerick|University of Bern|University of Valencia|Inesc Porto|Institut National de la Sant Et de la Recherche Mdicale, France|European Commission|Ministry of Science and Higher Education, Poland | 2015-06-01 | 2017-01-04 | |
NCT02291159 | Stroke|Spasticity | Device: DNHS (Dry Needling for Hypertonia and Spasticity)|Device: Sham Dry Needling | Universidad San Jorge | 2014-11-01 | 2014-12-30 | |
NCT02064569 | Leber Hereditary Optic Neuropathy | Genetic: GS010 | GenSight Biologics | Phase 1|Phase 2 | 2014-02-01 | 2017-02-22 |
NCT02619539 | Trauma, Multiple | Procedure: plasma fibrinogen measurement | Masaryk Hospital Krajsk zdravotn a.s. | 2016-01-01 | 2017-03-22 | |
NCT01608126 | Cervical Plexus Block Comparison | Procedure: cervical block | Daniel Nalos MD|Masaryk Hospital Krajsk zdravotn a.s. | 2011-01-01 | 2012-05-29 | |
NCT01508091 | Obesity | Behavioral: energy restricted mediterranean-type diet|Behavioral: 25 % calorie restriction | University of Chile | 2012-05-01 | 2012-10-20 | |
NCT02513693 | Neuromuscular Blockade | Drug: Standard neuromuscular blockade|Drug: Deep neuromuscular blockade | Palacky University|University Hospital Olomouc|Masaryk Hospital, Usti nad Labem | Phase 4 | 2015-07-01 | 2015-07-30 |
NCT03030586 | Alzheimer Disease|Frontotemporal Lobar Degeneration|Lewy Body Disease|Parkinson Disease Dementia|Progressive Supranuclear Palsy|Corticobasal Degeneration | Amoneta Diagnostics SAS|European Commission|Firalis SA|University Hospital, Strasbourg|Centre Hospitalier Universitaire Vaudois|IRCCS Centro San Giovanni di Dio Fatebenefratelli|H么pitaux Civils de Colmar|Istanbul University|Assistance Publique - H么pitaux de Paris|University Hospital, Lille|University Hospital, Geneva|Cliniques universitaires Saint-Luc- Universit Catholique de Louvain | 2016-11-01 | 2017-03-02 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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