Loratadine

氯雷他定,SCH29851,Loratidine,SCH 29851,SCH-29851,

Loratadine是H1受体反向激动剂,IC50>32 μM。

目录号
EY0992
EY0992
EY0992
纯度
99.17%
99.17%
99.17%
规格
50 mg
100 mg
500 mg
原价
140
190
485
售价
140
190
485
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Loratadine is a histamine H1 receptor antagonist, used to treat allergies. Also acts as a selective inhibitor of B(0)AT2 with IC50 of 4 μM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Cuboni S, et al. J Med Chem, 2014, 57(22), 9473-9479.

    分子式
    C22H23ClN2O2
    分子量
    382.88
    CAS号
    79794-75-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    50 mg/mL
    Water
    <1 mg/mL
    Ethanol
    77 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01311336 Pegfilgrastim-induced Back and Leg Pain Drug: Loratadine|Drug: placebo University of Vermont|Cancer and Leukemia Group B Phase 2 2011-05-01 2013-01-23
    NCT02593747 Histamine H1 Antagonists, Non-Sedating Drug: Loratadine oral solution|Drug: Loratadine (Claritin peach syrup) Bayer Phase 1 2015-12-01 2017-02-10
    NCT02305979 Leukemia|Lymphoma Drug: Loratadine Wake Forest University Health Sciences 2014-12-01 2017-02-20
    NCT00963573 Rhinitis Drug: Loratadine|Drug: Betamethasone Merck Sharp & Dohme Corp. Phase 4 2003-09-01 2015-04-20
    NCT00837915 Healthy Drug: Loratadine 10mg /Pseudoephedrine Sulfate 240 mg Extended-Release Tablets Ranbaxy Laboratories Limited|Ranbaxy Inc. 2002-06-01 2009-02-05
    NCT00730912 Perennial Allergic Rhinitis Drug: loratadine|Drug: loratadine|Drug: loratadine Merck Sharp & Dohme Corp. Phase 4 2008-06-01 2015-09-01
    NCT00845546 Healthy Drug: 10 mg Loratadine/240 mg Pseudoephedrine Sulfate Extended-Release Tablets Ranbaxy Laboratories Limited|Ranbaxy Inc. 2002-06-01 2009-02-16
    NCT00762983 Rhinitis, Allergic, Seasonal|Rhinitis, Allergic, Perennial|Urticaria|Pruritus Drug: loratadine Merck Sharp & Dohme Corp. 2008-03-01 2015-02-12
    NCT00776217 Healthy Drug: loratadine 10 mg orally disintegrating tablets Ranbaxy Laboratories Limited|Ranbaxy Inc. 2006-06-01 2008-10-20
    NCT00776282 Healthy Drug: loratadine 10 mg orally disintegrating Ranbaxy Laboratories Limited|Ranbaxy Inc. 2006-07-01 2008-10-20
    NCT02513290 Allergic Rhinitis Drug: Bilastine|Drug: Loratadine Universidade do Sul de Santa Catarina Phase 4 2013-08-01 2015-07-30
    NCT01228630 Perennial Allergic Rhinitis Drug: Cloratadd-D|Drug: Allegra-D Azidus Brasil|EMS S/A Phase 3 2011-08-01 2016-04-07
    NCT02932774 Allergic Rhinitis|Hay Fever|SAR|Rhinitis, Allergic, Seasonal Drug: Cetirizine|Drug: Loratadine|Other: Placebo Johnson & Johnson Consumer and Personal Products Worldwide|Pfizer Phase 4 2001-03-01 2016-11-27
    NCT01673620 Allergic Rhinitis Drug: Montelukast 10 mg/loratadine 10 mg|Drug: Placebo Merck Sharp & Dohme Corp. Phase 3 2012-07-01 2015-11-19
    NCT02576808 Rhinitis,Allergic Drug: Ginger extract|Drug: Loratadine Thai Traditional Medical Knowledge Fund|Thammasat University Phase 2 2015-10-01 2015-10-13
    NCT02392039 Lymphoma Drug: Pegfilgrastim|Drug: Loratadine|Other: Placebo|Behavioral: Questionnaires M.D. Anderson Cancer Center|Amgen 2015-12-01 2017-01-10
    NCT02653339 Rhinitis, Allergic, Perennial Drug: Qufeng Shengshi Fang and Loratadine|Drug: Loratadine Peking Union Medical College Hospital 2016-06-01 2016-04-21
    NCT01451996 Healthy Drug: Claritin University of Chicago Phase 4 2011-10-01 2013-12-09
    NCT00946608 Allergy Drug: Loratadine 10 mg Tablets Under Fasting Conditions (Sandoz, Inc.)|Drug: Loratadine 10 mg Tablets Under Fed Conditions (Sandoz, Inc.)|Drug: Claritin (Loratadine) 10 mg Tablets Under Fed Conditions (Schering) Sandoz Phase 1 2005-06-01 2009-07-24
    NCT01055756 Allergic Rhinitis Drug: Loratadine + Pseudoephedrine sulfate Azidus Brasil Phase 3 2010-01-01 2010-10-26
    NCT01469234 Rhinitis Drug: loratadine|Drug: fexofenadine|Drug: placebo to loratadine|Drug: placebo to fexofenadine Bayer Phase 4 2011-10-01 2015-02-20

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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