Pyridostigmine Bromide 是一种拟副交感神经的和可逆的胆碱酯酶抑制剂。
Pyridostigmine Bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Alon Bajayo et. Al. PNAS, 109(38), 15455-15460 (2012).
分子式 C9H13BrN2O2 |
分子量 261.12 |
CAS号 101-26-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 54 mg/mL |
Water 54 mg/mL |
Ethanol 54 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02357225 | Pompe Disease | Drug: Pyridostigmine Bromide | University of Florida | Early Phase 1 | 2015-08-01 | 2016-10-25 |
NCT01415921 | Heart Failure | Drug: Pyridostigmine Bromide | New York University School of Medicine|Nathan Kline Institute for Psychiatric Research|Oklahoma State University|National Heart, Lung, and Blood Institute (NHLBI) | Phase 2 | 2011-10-01 | 2016-08-31 |
NCT00276406 | Constipation|Diabetes Mellitus|Colonic Transit|Gastric Emptying | Drug: Pyridostigmine|Drug: Placebo | Mayo Clinic|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Center for Research Resources (NCRR) | Phase 1|Phase 2 | 2006-05-01 | 2012-11-02 |
NCT01993680 | Autonomic Disturbances in Parkinson`s Disease | Drug: Pyridostigmine bromide|Drug: fludrocortisone | University of Zurich | Phase 2 | 2012-06-01 | 2015-09-29 |
NCT02941328 | Spinal Muscular Atrophy|SMA|Kugelberg-Welander Disease | Drug: Pyridostigmine|Drug: Placebo | UMC Utrecht | Phase 2 | 2015-12-01 | 2016-10-19 |
NCT00953914 | Diabetes Complications | Drug: Pyridostigmine|Drug: Placebo | Hospital de Clinicas de Porto Alegre | 2005-03-01 | 2011-07-06 | |
NCT02307526 | Hypotension, Postural | Drug: Pyridostigmine Bromide | James J. Peters Veterans Affairs Medical Center | Phase 2 | 2011-01-01 | 2014-12-01 |
NCT02157545 | Muscle Relaxants | Shashi Bhatt, MD|University of Toledo Health Science Campus | Phase 4 | 2014-03-01 | 2016-07-15 | |
NCT01370512 | Orthostatic Hypotension | Drug: Droxidopa|Drug: Pyridostigmine Bromide | Mayo Clinic | Phase 2 | 2011-11-01 | 2016-09-12 |
NCT00518154 | HIV Infections | Drug: Pyridostigmine tablets | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | Phase 2 | 2007-09-01 | 2009-04-16 |
NCT02227823 | Spinal Muscular Atrophy Type 3 | Drug: Pyridostigmine Bromide | Centre Hospitalier Rgional de la Citadelle | Phase 2 | 2014-07-01 | 2014-08-26 |
NCT02364180 | Muscle Weakness | University of Toledo Health Science Campus | Phase 3 | 2013-12-01 | 2016-02-02 | |
NCT00409435 | Postural Tachycardia Syndrome | Drug: pyridostigmine|Drug: Placebo | Mayo Clinic|National Institutes of Health (NIH) | 2006-10-01 | 2017-03-21 | |
NCT00535587 | Fibromyalgia | Behavioral: Exercise|Drug: pyridostigmine|Drug: Placibo|Behavioral: Attention Control | Oregon Health and Science University|National Institute of Nursing Research (NINR) | Phase 2 | 2002-09-01 | 2011-03-23 |
NCT02850276 | HIV Disease | Drug: Pyridostigmine | Icahn School of Medicine at Mount Sinai|National Institutes of Health (NIH)|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Early Phase 1 | 2015-11-01 | 2016-07-27 |
NCT03063515 | Diabetes Mellitus | Drug: Pyridostigmine | University of Miami|American Diabetes Association | Phase 1 | 2017-03-01 | 2017-02-21 |
NCT02308124 | Orthostatic; Hypotension, Neurogenic | Drug: Midodrine|Drug: Pyridostigmine Bromide|Drug: Midodrine + pyridostigmine bromide | Seoul National University Hospital | Phase 4 | 2014-11-01 | 2015-04-15 |
NCT02893553 | Spinal Cord Injury|Autonomic Dysreflexia|Baroreceptor Integrity|Sympathetic Integrity|Vagal Integrity|Autonomic Integrity|Hypotensive|Cognitive Function|Cerebral Blood Flow|Blood Pressure | Drug: Midodrine Hydrochloride|Drug: Pyridostigmine Bromide|Drug: Mirabegron|Other: Placebo | James J. Peters Veterans Affairs Medical Center|Kessler Foundation | Phase 2 | 2016-12-01 | 2016-12-27 |
NCT02171988 | Postural Orthostatic Tachycardia Syndrome | Drug: Propranolol|Drug: Bisoprolol|Drug: Propranolol+pyridostigmine|Drug: Bisoprolol+pyridostgmine | Seoul National University Hospital | Phase 4 | 2014-03-01 | 2016-04-14 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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