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Pyridostigmine Bromide

溴吡啶斯的明

Pyridostigmine Bromide 是一种拟副交感神经的和可逆的胆碱酯酶抑制剂。

目录号
EY0981
EY0981
EY0981
纯度
99.37%
99.37%
99.37%
规格
500 mg
1 g
5 g
原价
470
660
1900
售价
470
660
1900
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Pyridostigmine Bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Alon Bajayo et. Al. PNAS, 109(38), 15455-15460 (2012).

    分子式
    C9H13BrN2O2
    分子量
    261.12
    CAS号
    101-26-8
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    54 mg/mL
    Water
    54 mg/mL
    Ethanol
    54 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02357225 Pompe Disease Drug: Pyridostigmine Bromide University of Florida Early Phase 1 2015-08-01 2016-10-25
    NCT01415921 Heart Failure Drug: Pyridostigmine Bromide New York University School of Medicine|Nathan Kline Institute for Psychiatric Research|Oklahoma State University|National Heart, Lung, and Blood Institute (NHLBI) Phase 2 2011-10-01 2016-08-31
    NCT00276406 Constipation|Diabetes Mellitus|Colonic Transit|Gastric Emptying Drug: Pyridostigmine|Drug: Placebo Mayo Clinic|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Center for Research Resources (NCRR) Phase 1|Phase 2 2006-05-01 2012-11-02
    NCT01993680 Autonomic Disturbances in Parkinson`s Disease Drug: Pyridostigmine bromide|Drug: fludrocortisone University of Zurich Phase 2 2012-06-01 2015-09-29
    NCT02941328 Spinal Muscular Atrophy|SMA|Kugelberg-Welander Disease Drug: Pyridostigmine|Drug: Placebo UMC Utrecht Phase 2 2015-12-01 2016-10-19
    NCT00953914 Diabetes Complications Drug: Pyridostigmine|Drug: Placebo Hospital de Clinicas de Porto Alegre 2005-03-01 2011-07-06
    NCT02307526 Hypotension, Postural Drug: Pyridostigmine Bromide James J. Peters Veterans Affairs Medical Center Phase 2 2011-01-01 2014-12-01
    NCT02157545 Muscle Relaxants Shashi Bhatt, MD|University of Toledo Health Science Campus Phase 4 2014-03-01 2016-07-15
    NCT01370512 Orthostatic Hypotension Drug: Droxidopa|Drug: Pyridostigmine Bromide Mayo Clinic Phase 2 2011-11-01 2016-09-12
    NCT00518154 HIV Infections Drug: Pyridostigmine tablets Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Phase 2 2007-09-01 2009-04-16
    NCT02227823 Spinal Muscular Atrophy Type 3 Drug: Pyridostigmine Bromide Centre Hospitalier Rgional de la Citadelle Phase 2 2014-07-01 2014-08-26
    NCT02364180 Muscle Weakness University of Toledo Health Science Campus Phase 3 2013-12-01 2016-02-02
    NCT00409435 Postural Tachycardia Syndrome Drug: pyridostigmine|Drug: Placebo Mayo Clinic|National Institutes of Health (NIH) 2006-10-01 2017-03-21
    NCT00535587 Fibromyalgia Behavioral: Exercise|Drug: pyridostigmine|Drug: Placibo|Behavioral: Attention Control Oregon Health and Science University|National Institute of Nursing Research (NINR) Phase 2 2002-09-01 2011-03-23
    NCT02850276 HIV Disease Drug: Pyridostigmine Icahn School of Medicine at Mount Sinai|National Institutes of Health (NIH)|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Early Phase 1 2015-11-01 2016-07-27
    NCT03063515 Diabetes Mellitus Drug: Pyridostigmine University of Miami|American Diabetes Association Phase 1 2017-03-01 2017-02-21
    NCT02308124 Orthostatic; Hypotension, Neurogenic Drug: Midodrine|Drug: Pyridostigmine Bromide|Drug: Midodrine + pyridostigmine bromide Seoul National University Hospital Phase 4 2014-11-01 2015-04-15
    NCT02893553 Spinal Cord Injury|Autonomic Dysreflexia|Baroreceptor Integrity|Sympathetic Integrity|Vagal Integrity|Autonomic Integrity|Hypotensive|Cognitive Function|Cerebral Blood Flow|Blood Pressure Drug: Midodrine Hydrochloride|Drug: Pyridostigmine Bromide|Drug: Mirabegron|Other: Placebo James J. Peters Veterans Affairs Medical Center|Kessler Foundation Phase 2 2016-12-01 2016-12-27
    NCT02171988 Postural Orthostatic Tachycardia Syndrome Drug: Propranolol|Drug: Bisoprolol|Drug: Propranolol+pyridostigmine|Drug: Bisoprolol+pyridostgmine Seoul National University Hospital Phase 4 2014-03-01 2016-04-14

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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