Chlorzoxazone是一种作用于中枢的肌肉松弛剂, 用于治疗肌肉痉挛,作为人体肝脏细胞色素P-450IIE1的探针。
Chlorzoxazone is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Lucas D, et al. Methods Enzymol, 1996, 272, 115-123.
分子式 C7H4ClNO2 |
分子量 169.57 |
CAS号 95-25-0 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 35 mg/mL |
Water <1 mg/mL |
Ethanol 35 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01342341 | Alcohol Abuse | Drug: Parafon Forte | University of California, San Francisco | Phase 4 | 2011-04-01 | 2014-05-23 |
NCT01933542 | Chlorzoxazone|Postoperative Pain | Drug: Placebo|Drug: Chlorzoxazone|Drug: Morphine|Drug: Zofran | Rigshospitalet, Denmark|Glostrup University Hospital, Copenhagen | Phase 4 | 2013-08-01 | 2015-09-16 |
NCT02405104 | Osteoarthritis of Hip|Osteoarthritis, Knee | Drug: chlorzoxazone|Drug: Placebo|Procedure: THA|Procedure: TKA | Northern Orthopaedic Division, Denmark | Phase 4 | 2015-09-01 | 2015-12-10 |
NCT01187862 | Cytochrome|Pharmacokinetics | Drug: caffeine, efavirenz, losartan, omeprazole, metoprolol, chlorzoxazone and midazolam | University Hospital, Basel, Switzerland | Phase 1 | 2010-07-01 | 2015-04-16 |
NCT00330434 | Alcohol Drinking|Depression|Smoking Cessation|Attention Deficit Disorder | Drug: Bupropion|Drug: Chlorzoxazone|Drug: Ethanol | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | 2005-12-01 | 2008-04-07 | |
NCT00138684 | Insulin Resistance|Iron Overload | Procedure: venesection | Rennes University Hospital|Ministry of Health, France | Phase 2 | 2003-09-01 | 2012-05-18 |
NCT00340535 | Normal Physiology | National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) | 2004-06-18 | 2017-01-24 | ||
NCT02291666 | Type 2 Diabetes | Drug: CRCHUM-MT cocktail | Centre hospitalier de l'Universit de Montral (CHUM)|Canadian Institutes of Health Research (CIHR) | Phase 4 | 2015-04-01 | 2016-06-27 |
NCT02654236 | Alcohol Consumption | Drug: Placebo|Drug: 10 mg Obeticholic Acid (OCA) | Suthat Liangpunsakul|National Institute on Alcohol Abuse and Alcoholism (NIAAA)|Intercept Pharmaceuticals|Indiana University | 2016-04-01 | 2016-11-04 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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