Enalapril maleate是enalapril的活性代谢物,是血管紧张素转化酶(ACE)抑制剂。
Enalapril Maleate is an angiotensin-converting enzyme (ACE) inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Itoh, Y., et al. 2002. J. Endocrinol. 175: 233-239. PMID: 12379508
[2] K E Kristensen et. Al. Clinical Pharmacology and Therapeutics, 96(6), 713-722 (2014).
[2] Jung Woo Eun et. Al. Journal of Applied Toxicology, 35(2), 152-164 (2015).
分子式 C24H32N2O9 |
分子量 492.52 |
CAS号 76095-16-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 101 mg/mL |
Water <1 mg/mL |
Ethanol 5 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00895414 | Breast Cancer | Drug: doxorubicin hydrochloride|Drug: enalapril maleate | Masonic Cancer Center, University of Minnesota | 2009-04-01 | 2015-04-23 | |
NCT00794885 | Primary Hypertension | Drug: Enalapril/folic acid|Drug: Enalapril maleate | Shenzhen Ausa Pharmed Co.,Ltd|Anhui Medical University | Phase 4 | 2008-05-01 | 2014-08-11 |
NCT01822639 | Hypertension | Drug: GSK2944404 FDC|Drug: Amlodipine 5 mg|Drug: Enalapril Maleate 20 mg | GlaxoSmithKline | Phase 1 | 2013-04-01 | 2016-11-18 |
NCT00741156 | Hypertension|Congestive Cardiomyopathy | Drug: Enalaprilat | The Hospital for Sick Children | Phase 3 | 2008-07-01 | 2015-11-16 |
NCT02252692 | Heart Failure | Drug: Enalapril | Ethicare GmbH|European Commission | Phase 1 | 2014-08-01 | 2014-09-26 |
NCT02652728 | Heart Failure|Dilated Cardiomyopathy | Drug: Enalapril Orodispersible Minitablet | Ethicare GmbH | Phase 2|Phase 3 | 2016-01-01 | 2016-01-08 |
NCT02652741 | Heart Failure|Congenital Heart Disease | Drug: Enalapril Orodispersible Minitablet | Ethicare GmbH | Phase 2|Phase 3 | 2016-01-01 | 2016-01-08 |
NCT02654678 | Heart Failure|Dilated Cardiomyopathy|Congenital Heart Disease | Drug: Enalapril Orodispersible Minitablet | Ethicare GmbH | Phase 2|Phase 3 | 2016-03-01 | 2016-01-12 |
NCT01871740 | Hypertension|Hyperhomocysteinemia | Drug: Enalapril maleate and folic acid tablets|Drug: Enalapril maleate | Shenzhen Ausa Pharmed Co.,Ltd|Nanfang Hospital of Southern Medical University | Phase 4 | 2008-05-01 | 2016-01-18 |
NCT01115946 | Healthy|Pharmacokinetics of Enalapril | Drug: ASP1585|Drug: enalapril | Astellas Pharma Inc | Phase 1 | 2010-03-01 | 2010-05-26 |
NCT00302705 | Hypertension | Drug: Valsartan, Enalapril|Device: Ambulatory blood pressure monitoring|Procedure: Missing one dose | University of Vigo|Hospital Clinico Universitario de Santiago|Novartis | Phase 4 | 2005-01-01 | 2009-01-02 |
NCT03051282 | Healthy Volunteers | Drug: Enalapril | University of Michigan | Phase 4 | 2017-02-28 | 2017-02-09 |
NCT01035255 | Heart Failure With Reduced Ejection Fraction | Drug: LCZ696 200 mg BID|Drug: Enalapril 10 mg BID | Novartis Pharmaceuticals|Novartis | Phase 3 | 2009-12-01 | 2016-07-13 |
NCT00853658 | Chronic Heart Failure | Drug: Enalapril|Drug: Aliskiren | Novartis Pharmaceuticals|Novartis | Phase 3 | 2009-03-01 | 2016-10-03 |
NCT02900378 | Chronic Heart Failure With Reduced Ejection Fraction | Drug: LCZ696 (sacubitril/valsartan)|Drug: Placebo to LCZ696 (sacubitril/valsartan)|Drug: Enalapril|Drug: Placebo to enalapril | Novartis Pharmaceuticals|Novartis | Phase 3 | 2016-12-01 | 2017-01-04 |
NCT01117038 | Erectile Dysfunction | Drug: avanafil and enalapril|Drug: avanafil and amlodipine | VIVUS, Inc. | Phase 1 | 2010-04-01 | 2011-08-09 |
NCT02768298 | Chronic Heart Failure With Reduced Ejection Fraction | Drug: LCZ696|Drug: enalapril|Drug: Enalapril matching placebo|Drug: LCZ696 matching placebo | Novartis Pharmaceuticals|Novartis | Phase 4 | 2016-07-01 | 2017-01-03 |
NCT00520247 | Plasma Total Homocysteine Level|Blood Pressure | Drug: enalapril plus folic acid | Anhui Medical University|Peking University First Hospital|Huashan Hospital|Harbin Medical University|China Medical University Hospital|First Affiliated Hospital Xi'an Jiaotong University|Nanjing Medical University | Phase 2 | 2005-09-01 | 2007-08-22 |
NCT02554890 | Acute Heart Failure | Drug: sacubitril/valsartan (LCZ696)|Drug: Enalapril|Drug: sacubitril/valsartan (LCZ696) matching placebo|Drug: enalapril matching placebo | Novartis Pharmaceuticals|Novartis | Phase 4 | 2016-04-01 | 2017-03-07 |
NCT02135263 | Carboxylesterase 1 (CES1) Genotype|CES1 Activity | Drug: Methylphenidate|Drug: Enalapril | Bispebjerg Hospital|The Ministry of Science, Technology and Innovation, Denmark|Mental Health Centre Sct. Hans (Denmark)|University of Copenhagen|The Leiden Academic Center for Drug Research (LACDR)|Duke University | Phase 4 | 2012-04-01 | 2014-07-29 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
相关化合物库
使用AMQUAR产品发表文献后请联系我们