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Enalapril Maleate

马来酸依那普利,MK-421 Maleate,MK 421 Maleate,MK 421 Maleate

Enalapril maleate是enalapril的活性代谢物,是血管紧张素转化酶(ACE)抑制剂。

目录号
EY0958
EY0958
EY0958
纯度
99.37%
99.37%
99.37%
规格
500 mg
1 g
5 g
原价
160
280
950
售价
160
280
950
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Enalapril Maleate is an angiotensin-converting enzyme (ACE) inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Itoh, Y., et al. 2002. J. Endocrinol. 175: 233-239. PMID: 12379508
    [2] K E Kristensen et. Al. Clinical Pharmacology and Therapeutics, 96(6), 713-722 (2014).
    [2] Jung Woo Eun et. Al. Journal of Applied Toxicology, 35(2), 152-164 (2015).

    分子式
    C24H32N2O9
    分子量
    492.52
    CAS号
    76095-16-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    101 mg/mL
    Water
    <1 mg/mL
    Ethanol
    5 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00895414 Breast Cancer Drug: doxorubicin hydrochloride|Drug: enalapril maleate Masonic Cancer Center, University of Minnesota 2009-04-01 2015-04-23
    NCT00794885 Primary Hypertension Drug: Enalapril/folic acid|Drug: Enalapril maleate Shenzhen Ausa Pharmed Co.,Ltd|Anhui Medical University Phase 4 2008-05-01 2014-08-11
    NCT01822639 Hypertension Drug: GSK2944404 FDC|Drug: Amlodipine 5 mg|Drug: Enalapril Maleate 20 mg GlaxoSmithKline Phase 1 2013-04-01 2016-11-18
    NCT00741156 Hypertension|Congestive Cardiomyopathy Drug: Enalaprilat The Hospital for Sick Children Phase 3 2008-07-01 2015-11-16
    NCT02252692 Heart Failure Drug: Enalapril Ethicare GmbH|European Commission Phase 1 2014-08-01 2014-09-26
    NCT02652728 Heart Failure|Dilated Cardiomyopathy Drug: Enalapril Orodispersible Minitablet Ethicare GmbH Phase 2|Phase 3 2016-01-01 2016-01-08
    NCT02652741 Heart Failure|Congenital Heart Disease Drug: Enalapril Orodispersible Minitablet Ethicare GmbH Phase 2|Phase 3 2016-01-01 2016-01-08
    NCT02654678 Heart Failure|Dilated Cardiomyopathy|Congenital Heart Disease Drug: Enalapril Orodispersible Minitablet Ethicare GmbH Phase 2|Phase 3 2016-03-01 2016-01-12
    NCT01871740 Hypertension|Hyperhomocysteinemia Drug: Enalapril maleate and folic acid tablets|Drug: Enalapril maleate Shenzhen Ausa Pharmed Co.,Ltd|Nanfang Hospital of Southern Medical University Phase 4 2008-05-01 2016-01-18
    NCT01115946 Healthy|Pharmacokinetics of Enalapril Drug: ASP1585|Drug: enalapril Astellas Pharma Inc Phase 1 2010-03-01 2010-05-26
    NCT00302705 Hypertension Drug: Valsartan, Enalapril|Device: Ambulatory blood pressure monitoring|Procedure: Missing one dose University of Vigo|Hospital Clinico Universitario de Santiago|Novartis Phase 4 2005-01-01 2009-01-02
    NCT03051282 Healthy Volunteers Drug: Enalapril University of Michigan Phase 4 2017-02-28 2017-02-09
    NCT01035255 Heart Failure With Reduced Ejection Fraction Drug: LCZ696 200 mg BID|Drug: Enalapril 10 mg BID Novartis Pharmaceuticals|Novartis Phase 3 2009-12-01 2016-07-13
    NCT00853658 Chronic Heart Failure Drug: Enalapril|Drug: Aliskiren Novartis Pharmaceuticals|Novartis Phase 3 2009-03-01 2016-10-03
    NCT02900378 Chronic Heart Failure With Reduced Ejection Fraction Drug: LCZ696 (sacubitril/valsartan)|Drug: Placebo to LCZ696 (sacubitril/valsartan)|Drug: Enalapril|Drug: Placebo to enalapril Novartis Pharmaceuticals|Novartis Phase 3 2016-12-01 2017-01-04
    NCT01117038 Erectile Dysfunction Drug: avanafil and enalapril|Drug: avanafil and amlodipine VIVUS, Inc. Phase 1 2010-04-01 2011-08-09
    NCT02768298 Chronic Heart Failure With Reduced Ejection Fraction Drug: LCZ696|Drug: enalapril|Drug: Enalapril matching placebo|Drug: LCZ696 matching placebo Novartis Pharmaceuticals|Novartis Phase 4 2016-07-01 2017-01-03
    NCT00520247 Plasma Total Homocysteine Level|Blood Pressure Drug: enalapril plus folic acid Anhui Medical University|Peking University First Hospital|Huashan Hospital|Harbin Medical University|China Medical University Hospital|First Affiliated Hospital Xi'an Jiaotong University|Nanjing Medical University Phase 2 2005-09-01 2007-08-22
    NCT02554890 Acute Heart Failure Drug: sacubitril/valsartan (LCZ696)|Drug: Enalapril|Drug: sacubitril/valsartan (LCZ696) matching placebo|Drug: enalapril matching placebo Novartis Pharmaceuticals|Novartis Phase 4 2016-04-01 2017-03-07
    NCT02135263 Carboxylesterase 1 (CES1) Genotype|CES1 Activity Drug: Methylphenidate|Drug: Enalapril Bispebjerg Hospital|The Ministry of Science, Technology and Innovation, Denmark|Mental Health Centre Sct. Hans (Denmark)|University of Copenhagen|The Leiden Academic Center for Drug Research (LACDR)|Duke University Phase 4 2012-04-01 2014-07-29

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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