Metronidazole是硝基咪唑类抗生素,对厌氧菌和原生动物较有效。
Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Samuelson J, et al. Antimicrob Agents Chemother, 1999, 43(7), 1533-1541.
分子式 C6H9N3O3 |
分子量 171.15 |
CAS号 443-48-1 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 35 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01255670 | Peritonsillar Abscess | Drug: penicillin and metronidazole in peritonsillar abscess | Helsinki University Central Hospital | 2010-02-01 | 2011-04-08 | |
NCT02392026 | Vaginosis, Bacterial | Drug: Metronidazole Gel | Watson Pharmaceuticals | Phase 4 | 2015-03-01 | 2016-10-31 |
NCT01937650 | Cervix Carcinoma | Drug: Radiotherapy plus metronidazole | Makerere University | Phase 2|Phase 3 | 2009-06-01 | 2013-09-04 |
NCT02393937 | Papulopustular Rosacea|Erythematotelangiectatic Rosacea | Drug: Reference: Metronidazole Gel 1%|Drug: Test: Metronidazole Gel 1%|Drug: Placebo Gel | bioRASI, LLC | Phase 3 | 2015-02-01 | 2016-11-29 |
NCT01559545 | Clostridium Difficile Associated Diarrhea | Drug: Metronidazole|Drug: Metronidazole-DRF1|Drug: Metronidazole-DRF2 | Dr. Reddy's Laboratories Limited|Reliance Clinical Research Services (Navi Mumbai, India) | Phase 2 | 2012-03-01 | 2013-06-06 |
NCT02328144 | Hemorrhoids | Drug: Metronidazole|Drug: Placebo | Instituto Mexicano del Seguro Social | Phase 3 | 2013-07-01 | 2014-12-26 |
NCT01222585 | Serious Systemic Infections|Necrotizing Enterocolitis | Drug: Metronidazole | Michael Cohen-Wolkowiez|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|The EMMES Corporation|Duke University | Phase 1 | 2011-01-01 | 2014-01-07 |
NCT02394821 | Neoplasm|Wounds and Injuries | Drug: Polihexanide 2%|Drug: Metronidazole 0.8% | University of Sao Paulo|Fundao de Amparo Pesquisa do Estado de So Paulo | Phase 3 | 2013-09-01 | 2015-09-01 |
NCT02200328 | Clostridium Difficile Diarrhea | Drug: Metronidazole|Drug: Placebo | Alison Schneider|Cleveland Clinic Florida | Phase 4 | 2014-08-01 | 2016-05-04 |
NCT00509639 | Crohn's Disease | Drug: 10% Metronidazole Ointment | S.L.A. Pharma AG | Phase 3 | 2005-05-01 | 2012-12-12 |
NCT01722708 | Abnormal Vaginal Flora|Clindamycin Vs Metronidazole|High Risk Pregnancies for Preterm Labor | Drug: Clindamycin|Drug: Metronidazole | HaEmek Medical Center, Israel | 2012-04-01 | 2016-10-30 | |
NCT01473836 | Intra-abdominal Infections | Drug: Metronidazole|Drug: Ceftriaxone sodium | Pfizer | Phase 3 | 2011-11-01 | 2013-12-18 |
NCT01020396 | Bacterial Vaginosis | Drug: Metronidazole|Drug: Metronidazole | Teva Pharmaceuticals USA | Phase 1|Phase 2 | 2002-01-01 | 2009-11-24 |
NCT01418365 | Healthy | Drug: Metronidazole + MMX Mesalazine/mesalamine placebo|Drug: Metronidazole + MMX Mesalazine/mesalamine | Shire | Phase 1 | 2011-08-01 | 2013-08-21 |
NCT00668655 | Rosacea | Drug: Metronidazole Gel | Galderma Laboratories, L.P. | 2008-02-01 | 2012-09-11 | |
NCT02186145 | Bacterial Vaginosis|Fungal Vaginal Infections | Drug: Association of metronidazole; nystatin and dexamethasone|Drug: Flagyl | Marjan Industria e Comercio ltda | Phase 3 | 2016-01-01 | 2015-04-08 |
NCT01230814 | Bacterial Vaginosis|Candidiasis|Trichomoniasis | Drug: Neo-Penotran Forte (active ingredient Metronidazole & Miconazole Nitrate)|Drug: Placebo | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 2 | 2011-04-01 | 2014-09-26 |
NCT01534247 | Healthy | Drug: CAZ-AVI|Drug: metronidazole|Drug: CAZ-AVI + metronidazole | AstraZeneca|Forest Laboratories | Phase 1 | 2012-02-01 | 2016-04-07 |
NCT01314976 | Dientamoebiasis | Drug: Metronidazole|Drug: Placebo | Statens Serum Institut | Phase 4 | 2011-07-01 | 2013-06-25 |
NCT01407016 | Infection | Drug: metronidazole IV 500 mg | Pfizer | Phase 1 | 2011-08-01 | 2011-09-27 |
NCT02561117 | Appendicitis | Drug: Metronidazole | Ahmed Nasr|Children's Hospital of Eastern Ontario | Phase 4 | 2017-06-01 | 2016-11-08 |
NCT01596894 | Crohn's Disease | Drug: Azithromycin + Metronidazole|Drug: Metronidazole | Prof. Arie Levine|Wolfson Medical Center | Phase 4 | 2012-10-01 | 2015-12-06 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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