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Metronidazole

甲硝哒唑

Metronidazole是硝基咪唑类抗生素,对厌氧菌和原生动物较有效。

目录号
EY0943
EY0943
EY0943
纯度
99.68%
99.68%
99.68%
规格
500 mg
1 g
5 g
原价
310
390
430
售价
310
390
430
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Samuelson J, et al. Antimicrob Agents Chemother, 1999, 43(7), 1533-1541.

    分子式
    C6H9N3O3
    分子量
    171.15
    CAS号
    443-48-1
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    35 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01255670 Peritonsillar Abscess Drug: penicillin and metronidazole in peritonsillar abscess Helsinki University Central Hospital 2010-02-01 2011-04-08
    NCT02392026 Vaginosis, Bacterial Drug: Metronidazole Gel Watson Pharmaceuticals Phase 4 2015-03-01 2016-10-31
    NCT01937650 Cervix Carcinoma Drug: Radiotherapy plus metronidazole Makerere University Phase 2|Phase 3 2009-06-01 2013-09-04
    NCT02393937 Papulopustular Rosacea|Erythematotelangiectatic Rosacea Drug: Reference: Metronidazole Gel 1%|Drug: Test: Metronidazole Gel 1%|Drug: Placebo Gel bioRASI, LLC Phase 3 2015-02-01 2016-11-29
    NCT01559545 Clostridium Difficile Associated Diarrhea Drug: Metronidazole|Drug: Metronidazole-DRF1|Drug: Metronidazole-DRF2 Dr. Reddy's Laboratories Limited|Reliance Clinical Research Services (Navi Mumbai, India) Phase 2 2012-03-01 2013-06-06
    NCT02328144 Hemorrhoids Drug: Metronidazole|Drug: Placebo Instituto Mexicano del Seguro Social Phase 3 2013-07-01 2014-12-26
    NCT01222585 Serious Systemic Infections|Necrotizing Enterocolitis Drug: Metronidazole Michael Cohen-Wolkowiez|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|The EMMES Corporation|Duke University Phase 1 2011-01-01 2014-01-07
    NCT02394821 Neoplasm|Wounds and Injuries Drug: Polihexanide 2%|Drug: Metronidazole 0.8% University of Sao Paulo|Fundao de Amparo Pesquisa do Estado de So Paulo Phase 3 2013-09-01 2015-09-01
    NCT02200328 Clostridium Difficile Diarrhea Drug: Metronidazole|Drug: Placebo Alison Schneider|Cleveland Clinic Florida Phase 4 2014-08-01 2016-05-04
    NCT00509639 Crohn's Disease Drug: 10% Metronidazole Ointment S.L.A. Pharma AG Phase 3 2005-05-01 2012-12-12
    NCT01722708 Abnormal Vaginal Flora|Clindamycin Vs Metronidazole|High Risk Pregnancies for Preterm Labor Drug: Clindamycin|Drug: Metronidazole HaEmek Medical Center, Israel 2012-04-01 2016-10-30
    NCT01473836 Intra-abdominal Infections Drug: Metronidazole|Drug: Ceftriaxone sodium Pfizer Phase 3 2011-11-01 2013-12-18
    NCT01020396 Bacterial Vaginosis Drug: Metronidazole|Drug: Metronidazole Teva Pharmaceuticals USA Phase 1|Phase 2 2002-01-01 2009-11-24
    NCT01418365 Healthy Drug: Metronidazole + MMX Mesalazine/mesalamine placebo|Drug: Metronidazole + MMX Mesalazine/mesalamine Shire Phase 1 2011-08-01 2013-08-21
    NCT00668655 Rosacea Drug: Metronidazole Gel Galderma Laboratories, L.P. 2008-02-01 2012-09-11
    NCT02186145 Bacterial Vaginosis|Fungal Vaginal Infections Drug: Association of metronidazole; nystatin and dexamethasone|Drug: Flagyl Marjan Industria e Comercio ltda Phase 3 2016-01-01 2015-04-08
    NCT01230814 Bacterial Vaginosis|Candidiasis|Trichomoniasis Drug: Neo-Penotran Forte (active ingredient Metronidazole & Miconazole Nitrate)|Drug: Placebo National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 2011-04-01 2014-09-26
    NCT01534247 Healthy Drug: CAZ-AVI|Drug: metronidazole|Drug: CAZ-AVI + metronidazole AstraZeneca|Forest Laboratories Phase 1 2012-02-01 2016-04-07
    NCT01314976 Dientamoebiasis Drug: Metronidazole|Drug: Placebo Statens Serum Institut Phase 4 2011-07-01 2013-06-25
    NCT01407016 Infection Drug: metronidazole IV 500 mg Pfizer Phase 1 2011-08-01 2011-09-27
    NCT02561117 Appendicitis Drug: Metronidazole Ahmed Nasr|Children's Hospital of Eastern Ontario Phase 4 2017-06-01 2016-11-08
    NCT01596894 Crohn's Disease Drug: Azithromycin + Metronidazole|Drug: Metronidazole Prof. Arie Levine|Wolfson Medical Center Phase 4 2012-10-01 2015-12-06

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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