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Praziquantel

吡喹酮,环吡异喹酮

Praziquantel是一种驱虫药，有效作用于扁形虫。

目录号
EY0942
EY0942
纯度
99.56%
99.56%
规格
100 mg
500 mg
原价
102
270
售价
102
270
库存
现货
现货
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  • 生物活性

    Praziquantel is an anthelmintic effective against flatworms.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Dan Zhang et. Al. Journal of Neuroscience, 31(44), 15983-15995 (2011).
    [2] Phedias Diamandis et. Al. Nature Chemical Biology, 3(5), 268-273 (2007).
    [3] R M Greenberg. Parasitology, 131 Suppl, S97-108 (2005).

    分子式
    C19H24N2O2    		 分子量
    312.41    		 CAS号
    55268-74-1    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    63 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    63 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01288872 Schistosomiasis [Bilharziasis] Drug: Praziquantel National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 2012-01-01 2013-09-26
    NCT02868385 Schistosomiasis Drug: 5x Praziquantel|Drug: 1x Praziquantel Leiden University Medical Center|Swiss Tropical & Public Health Institute|Centre Suisse de Recherches Scientifiques en C么te d'Ivoire Phase 4 2017-01-01 2016-08-11
    NCT00403611 Schistosomiasis Mansoni Drug: Praziquantel 60 mg/kg|Drug: Praziquantel 40 mg/kg Oswaldo Cruz Foundation|World Health Organization|Universidade Federal de Pernambuco Phase 4 2006-03-01 2015-06-16
    NCT01558336 Schistosomiasis Drug: praziquantel University of Khartoum|Hikma Pharmaceuticals LLC Phase 3 2008-08-01 2013-01-16
    NCT01054651 Schistosoma Mansoni Drug: Artesunate+Sulfamethoxypyrazine/pyrimethamine|Drug: Praziquantel Kenya Medical Research Institute|Dafra Pharma Phase 3 2009-10-01 2010-01-21
    NCT01529710 Schistosoma Hematobium Infection|Schistosomiasis Mansoni Drug: Myrrh Pharco Pharmaceuticals Phase 3 2011-12-01 2015-02-19
    NCT00441285 Neurocysticercosis|Epilepsy Drug: Praziquantel|Drug: Albendazole|Drug: ABZ Placebo|Drug: PZQ Placebo Universidad Peruana Cayetano Heredia|National Institute of Neurological Disorders and Stroke (NINDS) Phase 2|Phase 3 2010-01-01 2015-05-15
    NCT00215267 Schistosomiasis|Malaria Drug: praziquantel DBL -Institute for Health Research and Development|Ministry of Health, Uganda 2005-09-01 2008-02-19
    NCT01541631 Anemia|Intestinal Helminthiasis|Intestinal Schistosomiasis|Human Immunodeficiency Virus I Infection|Hematologic Diseases|Opportunistic Infections Drug: Praziquantel and Albendazole|Drug: Praziquantel and Albendazole|Drug: Praziquantel and Albendazole Catholic University of Health and Allied Sciences|National Institute for Medical Research, Tanzania|University of Cambridge 2012-05-01 2012-03-02
    NCT02325713 Healthy Drug: Oral dispersible tablet of praziquantel (ODT-PZQ)|Drug: Cysticide|Drug: ODT-PZQ|Drug: ODT-PZQ|Drug: ODT-PZQ|Drug: Cysticide Merck KGaA Phase 1 2015-01-01 2017-01-03
    NCT01901484 Intestinal Schistosomiasis Drug: Praziquantel Makerere University|University of Copenhagen Phase 2 2012-12-01 2014-09-16
    NCT02734186 Schistosomiasis Drug: Praziquantel National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) Phase 4 2016-03-14 2017-03-10
    NCT00510159 Schistosoma Haematobium Drug: Artesunate+Sulfamethoxypyrazine/pyrimethamin|Drug: Praziquantel Dafra Pharma Phase 2|Phase 3 2007-08-01 2008-01-17
    NCT02947581 Neurocysticercosis Drug: Albendazole and praziquantel|Drug: Albendazole and praziquantel placebo Universidad Peruana Cayetano Heredia Phase 3 2016-11-01 2016-10-25
    NCT00001205 Cysticercosis National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) 1985-07-22 2017-01-24
    NCT02806232 Schistosomiasis Drug: Biltricide (racemate praziquantel) oral tablets|Drug: Racemate Praziquantel ODT|Drug: Levo Praziquantel ODT Merck KGaA Phase 2 2016-06-01 2017-01-03
    NCT02878564 Schistosomiasis Mansoni|HIV Drug: Praziquantel University of Toronto|UVRI-IAVI HIV Vaccine Program, Uganda Phase 4 2016-03-01 2016-10-26
    NCT01260012 Schistosomiasis|Liver Fibrosis|Periportal Fibrosis|Oxidative Stress Dietary Supplement: Praziquantel+antioxidant suppl|Other: Praziquantel + placebo 2mths then antioxidant for 10 mths|Dietary Supplement: Praziquantel therapy and placebo as supplement|Dietary Supplement: Praziquantel+antioxidant Addis Ababa University|Ullevaal University Hospital|University of Oslo|University of Agder|Sorlandet Hospital HF 2010-01-01 2010-12-14
    NCT01050374 Parasitic Diseases Drug: albendazole + praziquantel|Drug: mebendazole + praziquantel DBL -Institute for Health Research and Development 2007-10-01 2010-01-14
    NCT01154907 Uro-genital Schistosomiasis Drug: praziquantel Oslo University Hospital|University of KwaZulu|University of Agder|Sorlandet Hospital HF|University of Copenhagen|Leiden University Medical Center|Universiteit Antwerpen 2010-04-01 2016-09-26

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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