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Erythromycin

红霉素,E-Mycin,E-Mycin,Erythrocin,Abomacetin,Erythromycin A

Erythromycin是口服大环内酯类抗生素,由红霉素链霉菌产生,能可逆地与细菌50S核糖体结合,抑制蛋白合成。

目录号
EY0941
EY0941
纯度
99.43%
99.43%
规格
500 mg
1 g
原价
330
410
售价
330
410
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Erythromycin is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin (IC50=1.5 μg/ml).

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Tran, J.Q., et al. 1999. J Clin Pharmacol. 39: 513-519. PMID: 10234600
    [2] Weisblum, B. 1984. Br. Med. Bull. 40: 47-53. PMID: 6442874
    [3] Berthet, S., et al. 2010. J Visc Surg. 147: e13-e18. PMID: 20655290
    [4] Tokairin, T., et al. 2005. Br J Clin Pharmacol. 60: 172-175. PMID: 16042670

    分子式
    C37H67NO13
    分子量
    733.93
    CAS号
    114-07-8
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    140 mg/mL
    Water
    2 mg/mL
    Ethanol
    140 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01340235 Epidermolysis Bullosa Drug: Oral erythromycin Centre Hospitalier Universitaire de Nice Phase 3 2011-06-01 2011-10-13
    NCT02175914 FAP-Familial Adenomatous Polyposis Drug: Erythromycin michal roll|Tel-Aviv Sourasky Medical Center Phase 4 2014-06-01 2014-06-25
    NCT02354560 FAP-Familial Adenomatous Polyposis Drug: Erythromycin michal roll|Tel-Aviv Sourasky Medical Center Phase 4 2015-06-01 2015-01-29
    NCT01556334 Preterm Premature Ruptured Membranes Drug: Azithromycin|Drug: Erythromycin Indiana University Phase 3 2010-04-01 2014-03-04
    NCT01323582 Gastroparesis Drug: Erythromycin|Drug: Azithromycin University of Florida|Metabolic Solutions Inc. Phase 2 2009-02-01 2014-12-04
    NCT01060267 Variceal Bleeding Drug: Erythromycin|Drug: Placebo King Abdulaziz Medical City 2007-01-01 2010-02-01
    NCT01478256 Blepharitis Drug: Erythromycin|Drug: Besifloxocin John, George, M.D.|Bausch & Lomb Incorporated Phase 4 2011-08-01 2013-11-20
    NCT01716572 Gastrointestinal Hemorrhage|Hematemesis Drug: Erythromycin|Procedure: gastric lavage Hospital Universitari de Bellvitge|Ministerio de Sanidad, Servicios Sociales e Igualdad Phase 3 2012-02-01 2015-10-07
    NCT02005029 Parkinson's Disease|Levodopa Drug: Erythromycin|Drug: placebo Virginia Commonwealth University 2013-04-01 2016-12-15
    NCT00318201 Healthy Drug: Erythromycin|Drug: Diltiazem Indiana University School of Medicine|Indiana University Phase 4 2006-04-01 2012-04-05
    NCT01274754 Functional Disturbances Following Cardiac Surgery AHEPA University Hospital|University of Thessaly 2008-11-01 2014-12-01
    NCT01117376 Gastroparesis Drug: Erythromycin|Drug: Methylnaltrexone Shiraz University of Medical Sciences Phase 2 2010-05-01 2011-03-30
    NCT01589614 Healthy Drug: PH-797804|Drug: PH-797804 + erythromycin Pfizer Phase 1 2012-06-01 2012-08-16
    NCT01659619 Subtotal Gastrectomy|Stomach Cancer Drug: Erythromycin The Catholic University of Korea Phase 2 2012-04-01 2013-02-20
    NCT03060473 Preterm Premature Rupture of Membranes (PPROM) Drug: Azithromycin|Drug: Erythromycin|Drug: Ampicillin|Drug: Amoxicillin The University of Texas Medical Branch, Galveston Phase 3 2017-03-01 2017-02-17
    NCT00304187 Bulimia Nervosa|Eating Disorders Drug: Erythromycin|Drug: Placebo New York State Psychiatric Institute|National Institute of Mental Health (NIMH) Phase 2 2004-09-01 2013-06-21
    NCT01342198 Healthy Drug: Pregabalin controlled release, 330 mg|Drug: Pregabalin controlled release, 330 mg|Drug: erythromycin Pfizer Phase 1 2011-06-01 2011-07-27
    NCT01379183 Healthy Drug: Erythromycin|Drug: Placebo|Procedure: Magnetic Resonance Imaging|Other: Barium Sulfate Solution Mayo Clinic|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Phase 2|Phase 3 2011-06-01 2016-02-19
    NCT01431248 Preterm Premature Rupture of Membranes University of Oklahoma|Indiana University School of Medicine 2011-09-01 2013-01-15
    NCT01825473 Gastroesophageal Reflux|Apnea|Bradycardia Drug: Erythromycin|Device: Multi-channel intra-luminal impedance (MII) pH monitoring|Drug: Placebo (D5W) University of Virginia 2012-09-01 2013-04-02

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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