Erythromycin是口服大环内酯类抗生素,由红霉素链霉菌产生,能可逆地与细菌50S核糖体结合,抑制蛋白合成。
Erythromycin is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin (IC50=1.5 μg/ml).
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Tran, J.Q., et al. 1999. J Clin Pharmacol. 39: 513-519. PMID: 10234600
[2] Weisblum, B. 1984. Br. Med. Bull. 40: 47-53. PMID: 6442874
[3] Berthet, S., et al. 2010. J Visc Surg. 147: e13-e18. PMID: 20655290
[4] Tokairin, T., et al. 2005. Br J Clin Pharmacol. 60: 172-175. PMID: 16042670
分子式 C37H67NO13 |
分子量 733.93 |
CAS号 114-07-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 140 mg/mL |
Water 2 mg/mL |
Ethanol 140 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01340235 | Epidermolysis Bullosa | Drug: Oral erythromycin | Centre Hospitalier Universitaire de Nice | Phase 3 | 2011-06-01 | 2011-10-13 |
NCT02175914 | FAP-Familial Adenomatous Polyposis | Drug: Erythromycin | michal roll|Tel-Aviv Sourasky Medical Center | Phase 4 | 2014-06-01 | 2014-06-25 |
NCT02354560 | FAP-Familial Adenomatous Polyposis | Drug: Erythromycin | michal roll|Tel-Aviv Sourasky Medical Center | Phase 4 | 2015-06-01 | 2015-01-29 |
NCT01556334 | Preterm Premature Ruptured Membranes | Drug: Azithromycin|Drug: Erythromycin | Indiana University | Phase 3 | 2010-04-01 | 2014-03-04 |
NCT01323582 | Gastroparesis | Drug: Erythromycin|Drug: Azithromycin | University of Florida|Metabolic Solutions Inc. | Phase 2 | 2009-02-01 | 2014-12-04 |
NCT01060267 | Variceal Bleeding | Drug: Erythromycin|Drug: Placebo | King Abdulaziz Medical City | 2007-01-01 | 2010-02-01 | |
NCT01478256 | Blepharitis | Drug: Erythromycin|Drug: Besifloxocin | John, George, M.D.|Bausch & Lomb Incorporated | Phase 4 | 2011-08-01 | 2013-11-20 |
NCT01716572 | Gastrointestinal Hemorrhage|Hematemesis | Drug: Erythromycin|Procedure: gastric lavage | Hospital Universitari de Bellvitge|Ministerio de Sanidad, Servicios Sociales e Igualdad | Phase 3 | 2012-02-01 | 2015-10-07 |
NCT02005029 | Parkinson's Disease|Levodopa | Drug: Erythromycin|Drug: placebo | Virginia Commonwealth University | 2013-04-01 | 2016-12-15 | |
NCT00318201 | Healthy | Drug: Erythromycin|Drug: Diltiazem | Indiana University School of Medicine|Indiana University | Phase 4 | 2006-04-01 | 2012-04-05 |
NCT01274754 | Functional Disturbances Following Cardiac Surgery | AHEPA University Hospital|University of Thessaly | 2008-11-01 | 2014-12-01 | ||
NCT01117376 | Gastroparesis | Drug: Erythromycin|Drug: Methylnaltrexone | Shiraz University of Medical Sciences | Phase 2 | 2010-05-01 | 2011-03-30 |
NCT01589614 | Healthy | Drug: PH-797804|Drug: PH-797804 + erythromycin | Pfizer | Phase 1 | 2012-06-01 | 2012-08-16 |
NCT01659619 | Subtotal Gastrectomy|Stomach Cancer | Drug: Erythromycin | The Catholic University of Korea | Phase 2 | 2012-04-01 | 2013-02-20 |
NCT03060473 | Preterm Premature Rupture of Membranes (PPROM) | Drug: Azithromycin|Drug: Erythromycin|Drug: Ampicillin|Drug: Amoxicillin | The University of Texas Medical Branch, Galveston | Phase 3 | 2017-03-01 | 2017-02-17 |
NCT00304187 | Bulimia Nervosa|Eating Disorders | Drug: Erythromycin|Drug: Placebo | New York State Psychiatric Institute|National Institute of Mental Health (NIMH) | Phase 2 | 2004-09-01 | 2013-06-21 |
NCT01342198 | Healthy | Drug: Pregabalin controlled release, 330 mg|Drug: Pregabalin controlled release, 330 mg|Drug: erythromycin | Pfizer | Phase 1 | 2011-06-01 | 2011-07-27 |
NCT01379183 | Healthy | Drug: Erythromycin|Drug: Placebo|Procedure: Magnetic Resonance Imaging|Other: Barium Sulfate Solution | Mayo Clinic|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Phase 2|Phase 3 | 2011-06-01 | 2016-02-19 |
NCT01431248 | Preterm Premature Rupture of Membranes | University of Oklahoma|Indiana University School of Medicine | 2011-09-01 | 2013-01-15 | ||
NCT01825473 | Gastroesophageal Reflux|Apnea|Bradycardia | Drug: Erythromycin|Device: Multi-channel intra-luminal impedance (MII) pH monitoring|Drug: Placebo (D5W) | University of Virginia | 2012-09-01 | 2013-04-02 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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