Flurbiprofen (氟比洛芬) 是非甾体抗炎化合物,有退热止痛的效果。
Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] King JG Jr, et al. Oncogene,?001, 20(47), 6864-6870.
分子式 C15H13FO2 |
分子量 244.26 |
CAS号 5104-49-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 50 mg/mL |
Water <1 mg/mL |
Ethanol 50 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02206854 | Healthy Volunteers | Drug: R-flurbiprofen | Gerd Geisslinger|Fraunhofer Institute for Molecular Biology and Applied Ecology|Goethe University | Phase 1 | 2014-06-01 | 2015-09-10 |
NCT00759330 | Chronic Low Back Pain | Drug: Placebo Tape (Arm 1)|Drug: Flurbiprofen Tape (Arm 2)|Drug: Placebo Tape (Arm 3)|Drug: Flurbiprofen Tape (Arm 4) | Teikoku Pharma USA | Phase 2 | 2007-10-01 | 2016-08-12 |
NCT00725218 | Postoperative Pain | Drug: Saline|Drug: Flurbiprofen Axetil | Nanjing Medical University | Phase 4 | 2008-05-01 | 2008-08-05 |
NCT01910090 | Healthy | Drug: FLURBIPROFEN 100 mg FAMOTIDINE 20 mg MULTI-LAYER TABLET|Drug: ANTADYS 100 mg, PEPCID 20 mg | Pharmaceutical Research Unit, Jordan | Phase 1 | 2012-12-01 | 2013-07-24 |
NCT00001724 | Pain | Drug: Flurbiprofen | National Institute of Dental and Craniofacial Research (NIDCR)|National Institutes of Health Clinical Center (CC) | Phase 2 | 1997-11-01 | 2008-03-03 |
NCT01048866 | Pharyngitis | Drug: Placebo|Drug: Flurbiprofen | Reckitt Benckiser LLC | Phase 3 | 2009-11-01 | 2011-04-01 |
NCT01049334 | Pharyngitis | Drug: Placebo|Drug: Flurbiprofen | Reckitt Benckiser LLC | Phase 3 | 2009-11-01 | 2011-04-01 |
NCT01040286 | Periodontitis | Drug: Flurbiprofen|Drug: Chlorhexidine | Dexcel Pharma Technologies Ltd. | Phase 2 | 2009-08-01 | 2010-07-05 |
NCT02367937 | Healthy | Drug: PRC-4016 (icosabutate) | Pronova BioPharma | Phase 1 | 2014-08-01 | 2015-02-13 |
NCT01986361 | Acute Pharyngitis|Sore Throat | Drug: flurbiprofen|Drug: placebo | Reckitt Benckiser LLC | Phase 3 | 2013-10-01 | 2013-11-11 |
NCT00425451 | Periodontitis | Drug: PerioChip Plus (Flurbiprofen +Chlorhexidine ), Flurbiprofen Chip, PerioChip (Chlorhexidine ) and Placebo Chip | Dexcel Pharma Technologies Ltd. | Phase 2 | 2008-08-01 | 2011-06-13 |
NCT01998217 | Pancreatic Stone Disease | Drug: Remifentanil|Drug: Flurbiprofen and remifentanil | Changhai Hospital | Phase 4 | 2012-09-01 | 2015-02-02 |
NCT02227173 | Drug-drug Interaction Study | Drug: BMS-986020|Drug: Montelukast|Drug: Flurbiprofen|Drug: Digoxin | Bristol-Myers Squibb | Phase 1 | 2014-09-01 | 2014-11-17 |
NCT02569905 | Postoperative Shivering | Drug: parecoxib sodium|Drug: flurbiprofen|Drug: saline | Guangxi Medical University | Phase 4 | 2014-04-01 | 2015-10-23 |
NCT02043366 | Pain|Anesthesia | Drug: Normal Saline|Drug: Butorphanol|Drug: Flurbiprofen axetil|Drug: Remifentanil|Drug: Sufentanil | Tianjin Medical University General Hospital | 2014-02-01 | 2015-12-08 | |
NCT02456844 | Rheumatoid Arthritis | Drug: Montelukast, Flurbiprofen, Midazolam, Digoxin, Pravastatin and BMS-986142|Drug: Methotrexate, Leucovorin and BMS-986142 | Bristol-Myers Squibb | Phase 1 | 2015-05-01 | 2016-01-29 |
NCT01026714 | Healthy Volunteers | Drug: flurbiprofen|Drug: flurbiprofen, rifampicin|Drug: flurbiprofen + fluconazole | University Hospital, Geneva | Phase 1|Phase 2 | 2009-11-01 | 2011-01-10 |
NCT03014713 | Patient-Controlled Analgesia | Drug: Dezocine|Drug: Flubiprofen|Drug: Dexmedetomidine | Weifeng Tu|Guangzhou General Hospital of Guangzhou Military Command | Phase 4 | 2016-09-01 | 2017-01-06 |
NCT03090009 | Peri-implant Mucositis | Drug: Flurbiprofen|Drug: Placebo Oral Tablet | Polak David|Hadassah Medical Organization | Early Phase 1 | 2017-04-01 | 2017-03-20 |
NCT02674737 | Postoperative Sedation,Gastrectomy, Enhanced Recovery After Surgery | Drug: dexmedetomidine, tramadol and flurbiprofen|Drug: tramadol and flurbiprofen | Chinese Medical Association | 2016-01-01 | 2016-02-03 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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