Clindamycin通过作用于50S ribosomal subunits(50S核糖体亚基)而抑制蛋白合成。
Clindamycin inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Keusch GT, et al. J Infect Dis, 1976, 133(5), 578-587.
分子式 C18H33ClN2O5S |
分子量 424.98 |
CAS号 18323-44-9 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 77 mg/mL |
Water <1 mg/mL |
Ethanol 77 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02782078 | Staphylococcal Infections | Biological: Clindamycin and rifampicin dosages | Assistance Publique - Hpitaux de Paris | 2016-06-01 | 2016-05-20 | |
NCT01744730 | Bacterial Infections|Obesity | Drug: Clindamycin | Phillip Brian Smith|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|The EMMES Corporation|Duke University | Phase 1 | 2013-06-01 | 2016-11-21 |
NCT02309346 | Septic Abortion | Drug: Clindamycin | Hospital de Clinicas de Porto Alegre | Phase 4 | 2014-12-01 | 2016-06-29 |
NCT01722708 | Abnormal Vaginal Flora|Clindamycin Vs Metronidazole|High Risk Pregnancies for Preterm Labor | Drug: Clindamycin|Drug: Metronidazole | HaEmek Medical Center, Israel | 2012-04-01 | 2016-10-30 | |
NCT01800825 | Pregnancy|Prematurity|Preterm Birth|Bacterial Vaginosis | Drug: Clindamycin|Drug: Placebo | Christiana Care Health Services|Jawaharlal Nehru Medical College|Thrasher Research Fund | Phase 4 | 2013-07-01 | 2016-07-15 |
NCT01132443 | Acne Vulgaris | Drug: Clindamycin 1%-Benzoyl Peroxide (BPO) 3% Gel, | Stiefel, a GSK Company|GlaxoSmithKline | Phase 1 | 2010-05-01 | 2016-11-30 |
NCT02475876 | Bacterial Infections | Drug: Clindamycin|Drug: trimethoprim-sulfamethoxazole | Michael Cohen-Wolkowiez|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Duke University | Phase 1 | 2015-11-01 | 2016-08-01 |
NCT01876628 | Cellulitis | Drug: Flucloxacillin and Clindamycin|Drug: Flucloxacillin and placebo | University Hospitals Bristol NHS Foundation Trust|University of Bristol|Public Health England | Phase 4 | 2013-10-01 | 2016-01-07 |
NCT01464138 | Malaria | Drug: Fosmidomycin and Clindamycin co-administration | Jomaa Pharma GmbH|Fundacio Clinic|Hospital Clinic of Barcelona | Phase 2 | 2010-09-01 | 2011-11-02 |
NCT01619410 | Skin Diseases, Bacterial|Abscess | Biological: Linezolid|Biological: Clindamycin | University of Chicago|Pfizer | 2012-01-01 | 2016-10-25 | |
NCT01361269 | Malaria | Drug: Fosmidomycin and clindamycin | Zentopharm GmbH|Albert Schweitzer Hospital|Centro de Investigacao em Saude de Manhica | Phase 2 | 2011-06-01 | 2011-05-25 |
NCT01422785 | Acne Vulgaris | Drug: clindamycin phosphate 1.2%/tretinoin 0.025% gel alone|Drug: clindamycin phosphate 1.2%/tretinoin 0.025% gel plus benzoyl peroxide 6% foaming cloths | Zeichner, Joshua, M.D. | Phase 4 | 2011-07-01 | 2011-08-22 |
NCT01015638 | Acne Vulgaris | Drug: Clindamycin and BPO 5% gel|Drug: Clindamycin phosphate and benzoyl peroxide 2.5% gel. | Stiefel, a GSK Company|GlaxoSmithKline | Phase 4 | 2009-08-01 | 2012-02-23 |
NCT01044264 | Acne Vulgaris | Drug: 1% Clindamycin/5% Benzoyl Peroxide Topical Gel|Drug: Placebo | Perrigo Company | 2007-12-01 | 2013-01-17 | |
NCT00837213 | Acne | Drug: Benzoyl peroxide with clindamycin|Drug: Benzoyl peroxide with clindamycin and doxycycline | Stiefel, a GSK Company|GlaxoSmithKline | Phase 4 | 2007-08-01 | 2011-07-12 |
NCT02479971 | Pain | Drug: Clindamycin-gentamicin irrigation|Drug: Normal saline irrigation | Hospital General Universitario Elche | Phase 3 | 2014-01-01 | 2015-06-22 |
NCT02721173 | Acne Vulgaris | Drug: Tazarotene 0.1% gel plus clindamycin 1% gel|Drug: Adapalene 0.1% gel plus clindamycin 1% gel | All India Institute of Medical Sciences, Bhubaneswar | Phase 4 | 2016-04-01 | 2017-01-17 |
NCT03033472 | Symptomatic Periapical Periodontitis | Drug: 600 mg Clindamycin orally|Drug: Oral Placebo | Cairo University | Phase 2|Phase 3 | 2017-01-26 | |
NCT00836004 | Healthy | Drug: Clindamycin 300 mg capsule|Drug: Cleocin HCl 300 mg capsules | Teva Pharmaceuticals USA | Phase 1 | 2003-11-01 | 2009-09-01 |
NCT00836056 | Healthy | Drug: Clindamycin 300 mg capsule|Drug: Cleocin HCl 300 mg capsules | Teva Pharmaceuticals USA | Phase 1 | 2003-11-01 | 2009-09-01 |
NCT01697826 | Vaginal Infections | Drug: ClinSupV3 -soft gelatin capsule|Drug: ClinSupV3ER- Extended release tablet | Dr Bharti Daswani|Resilient Cosmeceuticals Pvt. Ltd, Pune|Daswani, Bhart, M.D. | Phase 4 | 2011-04-01 | 2012-10-01 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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