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Clindamycin

克林霉素,氯林可霉素,氯洁霉素

Clindamycin通过作用于50S ribosomal subunits(50S核糖体亚基)而抑制蛋白合成。

目录号
EY0932
EY0932
EY0932
纯度
99.62%
99.62%
99.62%
规格
5 mg
10 mg
50 mg
原价
160
285
600
售价
160
285
600
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Clindamycin inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Keusch GT, et al. J Infect Dis, 1976, 133(5), 578-587.

    分子式
    C18H33ClN2O5S
    分子量
    424.98
    CAS号
    18323-44-9
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    77 mg/mL
    Water
    <1 mg/mL
    Ethanol
    77 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02782078 Staphylococcal Infections Biological: Clindamycin and rifampicin dosages Assistance Publique - Hpitaux de Paris 2016-06-01 2016-05-20
    NCT01744730 Bacterial Infections|Obesity Drug: Clindamycin Phillip Brian Smith|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|The EMMES Corporation|Duke University Phase 1 2013-06-01 2016-11-21
    NCT02309346 Septic Abortion Drug: Clindamycin Hospital de Clinicas de Porto Alegre Phase 4 2014-12-01 2016-06-29
    NCT01722708 Abnormal Vaginal Flora|Clindamycin Vs Metronidazole|High Risk Pregnancies for Preterm Labor Drug: Clindamycin|Drug: Metronidazole HaEmek Medical Center, Israel 2012-04-01 2016-10-30
    NCT01800825 Pregnancy|Prematurity|Preterm Birth|Bacterial Vaginosis Drug: Clindamycin|Drug: Placebo Christiana Care Health Services|Jawaharlal Nehru Medical College|Thrasher Research Fund Phase 4 2013-07-01 2016-07-15
    NCT01132443 Acne Vulgaris Drug: Clindamycin 1%-Benzoyl Peroxide (BPO) 3% Gel, Stiefel, a GSK Company|GlaxoSmithKline Phase 1 2010-05-01 2016-11-30
    NCT02475876 Bacterial Infections Drug: Clindamycin|Drug: trimethoprim-sulfamethoxazole Michael Cohen-Wolkowiez|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Duke University Phase 1 2015-11-01 2016-08-01
    NCT01876628 Cellulitis Drug: Flucloxacillin and Clindamycin|Drug: Flucloxacillin and placebo University Hospitals Bristol NHS Foundation Trust|University of Bristol|Public Health England Phase 4 2013-10-01 2016-01-07
    NCT01464138 Malaria Drug: Fosmidomycin and Clindamycin co-administration Jomaa Pharma GmbH|Fundacio Clinic|Hospital Clinic of Barcelona Phase 2 2010-09-01 2011-11-02
    NCT01619410 Skin Diseases, Bacterial|Abscess Biological: Linezolid|Biological: Clindamycin University of Chicago|Pfizer 2012-01-01 2016-10-25
    NCT01361269 Malaria Drug: Fosmidomycin and clindamycin Zentopharm GmbH|Albert Schweitzer Hospital|Centro de Investigacao em Saude de Manhica Phase 2 2011-06-01 2011-05-25
    NCT01422785 Acne Vulgaris Drug: clindamycin phosphate 1.2%/tretinoin 0.025% gel alone|Drug: clindamycin phosphate 1.2%/tretinoin 0.025% gel plus benzoyl peroxide 6% foaming cloths Zeichner, Joshua, M.D. Phase 4 2011-07-01 2011-08-22
    NCT01015638 Acne Vulgaris Drug: Clindamycin and BPO 5% gel|Drug: Clindamycin phosphate and benzoyl peroxide 2.5% gel. Stiefel, a GSK Company|GlaxoSmithKline Phase 4 2009-08-01 2012-02-23
    NCT01044264 Acne Vulgaris Drug: 1% Clindamycin/5% Benzoyl Peroxide Topical Gel|Drug: Placebo Perrigo Company 2007-12-01 2013-01-17
    NCT00837213 Acne Drug: Benzoyl peroxide with clindamycin|Drug: Benzoyl peroxide with clindamycin and doxycycline Stiefel, a GSK Company|GlaxoSmithKline Phase 4 2007-08-01 2011-07-12
    NCT02479971 Pain Drug: Clindamycin-gentamicin irrigation|Drug: Normal saline irrigation Hospital General Universitario Elche Phase 3 2014-01-01 2015-06-22
    NCT02721173 Acne Vulgaris Drug: Tazarotene 0.1% gel plus clindamycin 1% gel|Drug: Adapalene 0.1% gel plus clindamycin 1% gel All India Institute of Medical Sciences, Bhubaneswar Phase 4 2016-04-01 2017-01-17
    NCT03033472 Symptomatic Periapical Periodontitis Drug: 600 mg Clindamycin orally|Drug: Oral Placebo Cairo University Phase 2|Phase 3 2017-01-26
    NCT00836004 Healthy Drug: Clindamycin 300 mg capsule|Drug: Cleocin HCl 300 mg capsules Teva Pharmaceuticals USA Phase 1 2003-11-01 2009-09-01
    NCT00836056 Healthy Drug: Clindamycin 300 mg capsule|Drug: Cleocin HCl 300 mg capsules Teva Pharmaceuticals USA Phase 1 2003-11-01 2009-09-01
    NCT01697826 Vaginal Infections Drug: ClinSupV3 -soft gelatin capsule|Drug: ClinSupV3ER- Extended release tablet Dr Bharti Daswani|Resilient Cosmeceuticals Pvt. Ltd, Pune|Daswani, Bhart, M.D. Phase 4 2011-04-01 2012-10-01

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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