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Bisacodyl

双醋苯啶,比沙可啶

Bisacodyl是一种刺激性泻药，直接作用于结肠产生排便效应。

目录号
EY0928
EY0928
纯度
99.44%
99.44%
规格
100 mg
500 mg
原价
120
385
售价
120
385
库存
现货
现货
订购
订购
订购
订购
订购
订购
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  • 生物活性

    Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Ikarashi N, et al. Am J Physiol Gastrointest Liver Physiol, 2011, 301(5), G887-895.

    分子式
    C22H19NO4    		 分子量
    361.39    		 CAS号
    603-50-9    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    70 mg/mL    		 Water
    Insoluble    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01011426 Postoperative Nausea and Vomiting|Abdominal Pain Drug: Bisacodyl|Drug: placebo The Cooper Health System Phase 2 2009-04-01 2014-01-16
    NCT02980562 Bowel Disease|Colon Adenoma Drug: Polyethylene Glycols|Drug: Bisacodyl Korea University Anam Hospital Phase 3 2015-05-01 2016-12-01
    NCT01452737 Colonoscopy Drug: Standard Bowel Prep|Drug: 2L Golytely/bisacodyl University of British Columbia 2011-11-01 2013-09-17
    NCT01509131 Colonoscopy Drug: 2L PEG-CS plus bisacodyl|Drug: 2L PEG-ASC Promefarm S.r.l. Phase 4 2010-03-01 2012-01-11
    NCT00526097 Constipation Drug: Bisacodyl 10 mg|Drug: Placebo Boehringer Ingelheim Phase 3 2007-09-01 2013-12-13
    NCT01745835 Healthy Person|Bowel Preparation Before Colonoscopy Drug: 2L Coolprep|Drug: 1L Coolprep and Bisacodyl Seoul National University Hospital Phase 3 2013-01-01 2013-05-03
    NCT02123017 Colonoscopy Preparation Drug: 90 grams of Crystalline Lactulose|Drug: 135 grams of Crystalline Lactulose|Drug: 180 grams of Crystalline Lactulose Cumberland Pharmaceuticals Phase 2 2014-04-01 2016-01-27
    NCT01415687 Bowel Preparation for Colonoscopy Drug: Polyethylene Glycol-Based Lavage|Drug: Pico-Salax (Magnesium Citrate) plus Bisacodyl University of Calgary Phase 3 2011-05-01 2012-05-30
    NCT00509327 Postoperative Ileus Drug: bisacodyl|Drug: glucosemonohydricum University Hospital, Basel, Switzerland Phase 4 2004-11-01 2007-07-30
    NCT01887158 Intestinal Cancer Drug: Polyethylene glycol|Drug: Bisacodyl Ospedale Santa Maria delle Croci Phase 4 2013-07-01 2014-06-15
    NCT02211911 Healthy Drug: Bisacodyl|Drug: Sodium picosulfate Boehringer Ingelheim Phase 1 2008-02-01 2014-08-07
    NCT02211976 Constipation Drug: Bisacodyl|Drug: Simeticone Boehringer Ingelheim Phase 3 2003-10-01 2014-08-07
    NCT01063049 Preparation for Colonoscopy Drug: Gatorade/Miralax|Drug: NuLytely|Drug: Bisacodyl|Drug: Placebo Gastroenterology Services, Ltd. Phase 4 2010-02-01 2013-11-15
    NCT01427296 Colon Cleansing Drug: Polyethylene glycol|Drug: Oral sodium phosphate solution Valeant Pharmaceuticals International, Inc. Phase 4 2011-08-01 2014-05-30
    NCT02386449 Bowel Preparation Drug: sodium picosulfate, magnesium oxide and citric acid (Picoprep)|Drug: mannitol|Drug: Bisacodyl Ferring Pharmaceuticals Phase 4 2015-02-01 2016-01-11
    NCT02609607 Constipation|Fecal Incontinence|Multiple Sclerosis Drug: Bisacodyl|Other: Placebo University of Pittsburgh|Consortium of Multiple Sclerosis Centers Phase 2 2016-06-01 2016-10-25

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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