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Risperidone

利培酮,R-64766,Risperdal,R 64766,R64766,

Risperidone（R64766）是5-HT2受体阻断剂和多巴胺D2受体拮抗剂，Ki值分别为0.16和1.4nM。

目录号
EY0910
EY0910
EY0910
EY0910
纯度
99.27%
99.27%
99.27%
99.27%
规格
1 mg
5 mg
10 mg
50 mg
原价
140
286
480
992
售价
140
286
480
992
库存
现货
现货
现货
现货
订购
订购
订购
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  • 生物活性

    Risperidone is a mutil-targeted antagonist for dopamine, serotonin, adrenergic and histamine receptors, used to treat schizophrenia and bipolar disorder.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Angelucci F, et al. J Neurosci Res,?000, 60(6), 783-794.
    [2] Stathis et al (1996) Risperidone: a novel antipsychotic with many "atypical" properties. Psychopharmacol. 127 181.
    [3] Leysen et al (1994) Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J.Clin.Psychiatry 55 (Suppl.) 5.
    [4] Leysen et al (1988) Biochemical profile of risperidone, a new antipsychotic. J.Pharmacol.Exp.Ther. 247 661.

    分子式
    C23H27FN4O2    		 分子量
    410.48    		 CAS号
    106266-06-2    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    10 mM    		 Water
    Insoluble    		 Ethanol
    10 mM

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00526877 Schizophrenia|Schizoaffective Disorders Drug: Risperidone Johnson & Johnson Taiwan Ltd Phase 4 2007-07-01 2014-02-27
    NCT00294255 Bipolar Disorder Drug: Risperidone The University of Texas Health Science Center at San Antonio|Janssen, LP Phase 4 2003-03-01 2013-02-27
    NCT01726335 Schizophrenia Drug: Risperidone prolonged release Janssen-Cilag Ltd. Phase 4 2006-01-01 2014-04-10
    NCT01064271 Healthy Drug: Risperidone Dr. Reddy's Laboratories Limited Phase 1 2006-10-01 2010-02-04
    NCT01064232 Healthy Drug: Risperidone Dr. Reddy's Laboratories Limited Phase 1 2006-10-01 2010-02-04
    NCT01155934 Healthy Drug: Risperidone Orally Disintegrating Tablets Dr. Reddy's Laboratories Limited Phase 1 2004-08-01 2010-07-01
    NCT01155921 Healthy Drug: Risperidone Orally Disintegrating Tablets Dr. Reddy's Laboratories Limited Phase 1 2004-08-01 2010-07-01
    NCT00130923 Schizophrenia|Psychotic Disorders|Substance Abuse|Alcohol Abuse Drug: Risperidone Long Acting|Drug: oral risperidone Dartmouth-Hitchcock Medical Center|Janssen, LP Phase 4 2005-09-01 2015-08-03
    NCT00821600 Psychotic Disorders|Schizophrenia Drug: risperidone IR and LAI formulation Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Phase 1 2008-12-01 2014-05-20
    NCT00992407 Schizophrenia Drug: Risperidone long acting injectables|Drug: Risperidone tablets Janssen Korea, Ltd., Korea Phase 4 2007-12-01 2014-02-06
    NCT01894984 Schizophrenia Drug: Risperidone|Drug: Oral atypical anti-psychotic Xian-Janssen Pharmaceutical Ltd. Phase 4 2007-01-01 2014-04-22
    NCT01222923 Healthy Drug: Risperidone Ranbaxy Laboratories Limited|Ranbaxy Inc. 2004-10-01 2010-10-15
    NCT01222975 Healthy Drug: Risperidone Ranbaxy Laboratories Limited|Ranbaxy Inc. 2004-10-01 2010-10-15
    NCT00140426 Anorexia Nervosa Drug: Risperidone|Drug: Placebo University of Colorado, Denver|Janssen Pharmaceuticals|National Center for Research Resources (NCRR) Phase 4 2004-08-01 2015-12-29
    NCT00277654 Bipolar Disorder|Anxiety Disorder Drug: Risperidone Lindner Center of HOPE|Janssen Pharmaceuticals|University of Cincinnati Phase 3 2004-02-01 2011-12-12
    NCT01855074 Schizophrenia|Schizophreniform Disorder|Schizoaffective Disorder Drug: Risperidone Janssen-Cilag Ltd. Phase 4 2007-11-01 2013-08-06
    NCT01171937 Autism Drug: Risperidone|Drug: Placebo University of California, Los Angeles|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 2 2008-09-01 2016-01-11
    NCT01813643 Methamphetamine Dependence Drug: Risperidone|Drug: Aripiprazole Wei Hao|Central South University Phase 4 2012-07-01 2015-02-02
    NCT00177164 Bipolar I Disorder Drug: Injectable Risperidone (Consta) or oral antipsychotic University of Pittsburgh|Janssen Pharmaceuticals Phase 3 2003-11-01 2016-03-17
    NCT00622011 Delirium Drug: Risperidone and Zolpidem for delirium Changhua Christian Hospital Phase 4 2008-01-01 2008-02-11
    NCT00246194 Schizophrenia Drug: risperidone (RISPERDAL CONSTA) Janssen, LP Phase 4 2004-09-01 2014-04-02
    NCT01822730 Methamphetamine Dependence Drug: paliperidone|Drug: Risperidone Wei Hao|Central South University Phase 4 2013-02-01 2015-02-02
    NCT00848432 Schizophrenia Drug: risperidone Capital Medical University Phase 4 2002-12-01 2009-02-23

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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