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Beclomethasone dipropionate

Beclometasone dipropionate是糖皮质素激动剂，为beclometasone游离形式的原药。

目录号
EY0906
EY0906
纯度
99.61%
99.61%
规格
250 mg
500 mg
原价
550
880
售价
550
880
库存
现货
现货
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  • 生物活性

    Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Ratner PH, et al. Clin Ther, 2012, 34(6), 1422-1431.
    [2] Young PG, Skinner SJ, Black PN. Effects of glucocorticoids and beta-adrenoceptor agonists on the proliferation of airway smooth muscle. Eur J Pharmacol. 1995 Jan 24;273(1-2):137-43.
    [3] Delacourt C, Dutau G, Lefran?ois G, Comparison of the efficacy and safety of nebulized beclometasone dipropionate and budesonide in severe persistent childhood asthma. Respir Med. 2003 Feb;97 Suppl B:S27-33.

    分子式
    C28H37ClO7    		 分子量
    521.04    		 CAS号
    5534-09-8    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    102 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    18 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02381158 Wheezing Drug: Nebulized beclomethasone dipropionate Istituto di Biomedicina e Immunologia Molecolare Alberto Monroy Phase 4 2015-02-01 2017-01-19
    NCT01006655 Asthma|Bronchial Hyperresponsiveness Drug: Beclomethasone dipropionate HFA|Drug: placebo Rambam Health Care Campus|Teva Pharmaceutical Industries Phase 2 2009-03-01 2015-10-28
    NCT00862264 Asthma Drug: Fixed combination Beclomethasone Dipropionate/Formoterol HFA 134a-pMDI Chiesi Farmaceutici S.p.A. Phase 3 2004-08-01 2012-02-14
    NCT02513160 Persistent Asthma Drug: Beclomethasone Dipropionate|Drug: Placebo Teva Branded Pharmaceutical Products, R&D Inc.|Teva Pharmaceutical Industries Phase 3 2015-09-01 2016-04-12
    NCT02646904 Allergic Rhinitis Drug: Nasal Beclomethasone Dipropionate|Drug: CERCHIO 10 mg/ml OS Stefania La Grutta, MD|Istituto di Biomedicina e Immunologia Molecolare Alberto Monroy Phase 4 2016-02-01 2017-03-15
    NCT02030457 Pharmacokinetics Drug: Beclomethasone dipropionate BAI|Drug: Beclomethasone dipropionate MDI Teva Branded Pharmaceutical Products, R&D Inc.|Teva Pharmaceutical Industries Phase 1 2013-12-01 2014-07-08
    NCT00071552 Asthma Drug: Qvar|Drug: Flovent Diskus Teva Branded Pharmaceutical Products, R&D Inc.|Teva Pharmaceutical Industries Phase 4 2004-01-01 2014-05-09
    NCT01632540 Perennial Allergic Rhinitis (PAR) Drug: Beclomethasone Dipropionate (BDP) Nasal Aerosol Teva Pharmaceutical Industries|United BioSource Corporation 2012-07-01 2014-04-14
    NCT01877954 Asthma Drug: Extra-fine hydrofluoroalkane beclometasone dipropionate|Drug: Fluticasone propionate Research in Real-Life Ltd|Teva Pharmaceutical Industries 2011-02-01 2013-06-13
    NCT01691677 Acute Rhinosinusitis Drug: beclomethasone dipropionate 800 mcg/2 ml suspension for nebulization,one administration b.i.d. for 14 days|Drug: placebo 2 ml suspension for nebulization, one administration b.i.d. for 14 days Chiesi Farmaceutici S.p.A. Phase 3 2013-01-01 2015-01-19
    NCT02687100 Anesthesia, Endotracheal Drug: Beclomethasone|Drug: Placebo Policlinico Universitario Agostino Gemelli Phase 4 2016-10-01 2016-08-19
    NCT00788463 Nasal Polyps Drug: Intranasal Beclomethasone aerosol|Drug: Intranasal Beclomethasone spray Lawson Health Research Institute Phase 2 2008-03-01 2008-11-07
    NCT01400217 Asthma Drug: extra fine particle hydrofluoroalkane beclomethasone dipropionate via metered dose inhaler|Drug: standard particle particle hydrofluoroalkane beclomethasone dipropionate via metered dose inhaler Research in Real-Life Ltd|Teva Pharmaceutical Industries 1991-01-01 2012-10-29
    NCT00233896 Graft Vs Host Disease|Gastrointestinal Graft-Versus-Host Disease Drug: Oral beclomethasone dipropionate (drug) Enteron Pharmaceuticals Phase 3 2001-07-01 2005-10-04
    NCT01373008 Bronchopulmonary Dysplasia Drug: Inhaled extra-fine hydrofluoalkane-beclomethasone (QVAR) Bnai Zion Medical Center|Tel-Aviv Sourasky Medical Center|Schneider Children's Medical Center, Israel|Meir Hospital, Kfar Saba, Israel|Kaplan Medical Center|Barzilai Medical Center|Laniado Hospital|HaEmek Medical Center, Israel Phase 2 2011-06-01 2015-08-11
    NCT01658891 Asthma in Children Drug: combination of beclomethasone dipropionate 50g + formoterol fumarate 6g|Drug: free combination of beclomethasone dipropionate 100g + Formoterol fumarate 6g Chiesi Farmaceutici S.p.A. Phase 3 2014-02-01 2013-02-18
    NCT02040779 Persistent Asthma Drug: Beclomethasone dipropionate breath-actuated inhaler|Drug: Placebo breath-actuated inhaler|Drug: albuterol/salbutamol Teva Branded Pharmaceutical Products, R&D Inc.|Teva Pharmaceutical Industries Phase 3 2013-12-01 2015-05-21
    NCT01287351 Asthma Drug: extra-fine hydrofluoroalkane beclometasone dipropionate|Drug: Fluticasone propionate Research in Real-Life Ltd|i3 Research|Teva Pharmaceutical Industries 2004-01-01 2013-08-02
    NCT01016223 Eosinophilic Esophagitis Drug: Beclomethasone dipropionate|Drug: placebo Penn State University Phase 1 2010-03-01 2012-11-29
    NCT01265342 Bronchial Spasm|Respiratory Sounds|Respiratory Tract Infections Drug: Beclomethasone|Drug: Placebo Mario Negri Institute for Pharmacological Research|Agenzia Italiana del Farmaco|Associazione Culturale Pediatri Phase 4 2010-10-01 2014-03-10

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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