Naproxen sodium是COX抑制剂,对COX-1和COX-2的IC50分别为8.7 μM和5.2 μM。
Naproxen Sodium is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.
溶于培养基中,20 mM 左右
2.5,10或25 mg/kg静脉注射或腹腔注射
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Mitchell JA, et al. Proc Natl Acad Sci, 1993, 90(24), 11693-11697.
[2] Kumar et al (2006) Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats. Eur.J.Pharmacol. 551 58.
[3] Dhir et al (2006) Protective effect of naproxen (non-selective COX-inhibitor) or rofecoxib (selective COX-2 inhibitor) on immobilization stress-induced behavioral and biochemical alterations in mice. Eur.J.Pharmacol. 535 192.
分子式 C14H13O3.Na |
分子量 252.24 |
CAS号 26159-34-2 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 3 mg/mL |
Water 48 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01131767 | Healthy | Drug: Naproxen Sodium & Pseudoephedrine HCl | Dr. Reddy's Laboratories Limited | Phase 1 | 2004-07-01 | 2010-06-11 |
NCT01131728 | Healthy | Drug: Naproxen Sodium & Pseudoephedrine HCl | Dr. Reddy's Laboratories Limited | Phase 1 | 2004-07-01 | 2010-06-11 |
NCT00969449 | Pharmacokinetics | Drug: Naproxen Sodium, (BAY H6689)|Drug: Naprelan, (BAY H6689) | Bayer | Phase 1 | 2009-04-01 | 2014-05-19 |
NCT01052129 | Healthy | Drug: Naproxen sodium | Dr. Reddy's Laboratories Limited | Phase 1 | 2006-05-01 | 2010-05-26 |
NCT01052792 | Healthy | Drug: Naproxen Sodium | Dr. Reddy's Laboratories Limited | Phase 1 | 2006-05-01 | 2010-01-19 |
NCT00488514 | Migraine Disorders | Drug: Combination Tablet of Treximet (sumatriptan/naproxen sodium) | GlaxoSmithKline | Phase 3 | 2007-07-01 | 2016-10-11 |
NCT01952652 | Arthroscopic Meniscus Surgery | Drug: Group N:Naproxen sodium|Drug: Group NC :naproxen sodium codeine phosphate | Baskent University | Phase 4 | 2013-01-01 | 2013-09-26 |
NCT01383486 | Pain | Drug: Naproxen sodium ER (BAYH6689)|Drug: Advil | Bayer | Phase 3 | 2011-07-01 | 2015-09-24 |
NCT01389284 | Pain, Postoperative | Drug: Naproxen Sodium ER (BAYH6689)|Drug: Naproxen Sodium IR (Aleve, BAYH6689)|Drug: Naproxen Sodium ER Placebo|Drug: Naproxen Sodium IR Placebo | Bayer | Phase 3 | 2011-06-01 | 2015-08-12 |
NCT00792636 | Migraine Disorders | Drug: sumatriptan and naproxen sodium combination tablet|Drug: sumatriptan tablet|Drug: naproxen sodium tablet | GlaxoSmithKline | Phase 4 | 2008-11-01 | 2016-10-11 |
NCT00818415 | Pain | Drug: Naproxen sodium ER (BAYH6689)|Drug: Commercial Naproxen (Aleve, BAYH6689) | Bayer | Phase 1 | 2008-11-01 | 2014-05-16 |
NCT00586365 | Heterotopic Ossification | Drug: Naproxen | Massachusetts General Hospital | Phase 4 | 2007-10-01 | 2012-03-20 |
NCT01495858 | Pain, Postoperative | Drug: Naproxen Sodium 440 mg / DPH 25 mg (BAY98-7111)|Drug: Naproxen Sodium 440 mg (BAYH6689)|Drug: DPH 50 mg | Bayer | Phase 3 | 2011-12-01 | 2015-05-13 |
NCT00720057 | Toothache | Drug: Naproxen Sodium ER (BAYH6689)|Drug: Placebo | Bayer | Phase 3 | 2008-06-01 | 2015-08-12 |
NCT03092193 | Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant|Poor Metabolizer Due to Cytochrome p450 CYP2C19 Variant | Drug: Naproxen|Drug: Naproxen-esomeprazole | University of Sao Paulo|Fundao de Amparo Pesquisa do Estado de So Paulo | Phase 4 | 2017-03-01 | 2017-03-24 |
NCT00966641 | Healthy Volunteers | Drug: Naproxen|Drug: PL 3100 | PLx Pharma|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | Phase 1|Phase 2 | 2009-08-01 | 2015-08-06 |
NCT01280591 | Pain, Postoperative | Drug: Naproxen sodium 440 mg / DPH 50 mg (BAY98-7111)|Drug: Naproxen sodium 220 mg / DPH 50 mg (BAY98-7111)|Drug: Naproxen sodium 440 mg (BAYH6689)|Drug: DPH 50 mg | Bayer | Phase 3 | 2010-10-01 | 2015-05-13 |
NCT02494856 | Pain|Other Surgical Procedures|Impacted Third Molar Tooth | Drug: Surgery with Naproxen|Drug: Surgery with Naproxen and Esomeprazole | Giovana Maria Weckwerth|Fundao de Amparo Pesquisa do Estado de So Paulo|University of Sao Paulo | Phase 4 | 2014-10-01 | 2016-11-03 |
NCT02702817 | Alzheimer Disease|Cognitive Decline Due to Alzheimer Disease|Mild Cognitive Impairment Due to Alzheimer Disease | Drug: Naproxen|Drug: Placebo | Douglas Mental Health University Institute|McGill University|Johns Hopkins University | Phase 2 | 2012-08-01 | 2016-03-03 |
NCT02229461 | Hematology | Drug: Naproxen Sodium (Aleve, BAY117031)|Drug: Acetylsalicylic Acid (Aspirin, BAYE4465) | Bayer | Phase 1 | 2015-02-01 | 2016-06-16 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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