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Naproxen Sodium

萘普生钠,甲氧奈丙酸钠,RS3650,RS 3650,Naprelan,Anaprox,RS-36560,Naprelan,Anaprox

Naproxen sodium是COX抑制剂,对COX-1和COX-2的IC50分别为8.7 μM和5.2 μM。

目录号
EY0900
EY0900
纯度
99.79%
99.79%
规格
500 mg
1 g
原价
370
450
售价
370
450
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Naproxen Sodium is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    溶于培养基中,20 mM 左右

  • 动物实验

    2.5,10或25 mg/kg静脉注射或腹腔注射

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Mitchell JA, et al. Proc Natl Acad Sci, 1993, 90(24), 11693-11697.
    [2] Kumar et al (2006) Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats. Eur.J.Pharmacol. 551 58.
    [3] Dhir et al (2006) Protective effect of naproxen (non-selective COX-inhibitor) or rofecoxib (selective COX-2 inhibitor) on immobilization stress-induced behavioral and biochemical alterations in mice. Eur.J.Pharmacol. 535 192.

    分子式
    C14H13O3.Na
    分子量
    252.24
    CAS号
    26159-34-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    3 mg/mL
    Water
    48 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01131767 Healthy Drug: Naproxen Sodium & Pseudoephedrine HCl Dr. Reddy's Laboratories Limited Phase 1 2004-07-01 2010-06-11
    NCT01131728 Healthy Drug: Naproxen Sodium & Pseudoephedrine HCl Dr. Reddy's Laboratories Limited Phase 1 2004-07-01 2010-06-11
    NCT00969449 Pharmacokinetics Drug: Naproxen Sodium, (BAY H6689)|Drug: Naprelan, (BAY H6689) Bayer Phase 1 2009-04-01 2014-05-19
    NCT01052129 Healthy Drug: Naproxen sodium Dr. Reddy's Laboratories Limited Phase 1 2006-05-01 2010-05-26
    NCT01052792 Healthy Drug: Naproxen Sodium Dr. Reddy's Laboratories Limited Phase 1 2006-05-01 2010-01-19
    NCT00488514 Migraine Disorders Drug: Combination Tablet of Treximet (sumatriptan/naproxen sodium) GlaxoSmithKline Phase 3 2007-07-01 2016-10-11
    NCT01952652 Arthroscopic Meniscus Surgery Drug: Group N:Naproxen sodium|Drug: Group NC :naproxen sodium codeine phosphate Baskent University Phase 4 2013-01-01 2013-09-26
    NCT01383486 Pain Drug: Naproxen sodium ER (BAYH6689)|Drug: Advil Bayer Phase 3 2011-07-01 2015-09-24
    NCT01389284 Pain, Postoperative Drug: Naproxen Sodium ER (BAYH6689)|Drug: Naproxen Sodium IR (Aleve, BAYH6689)|Drug: Naproxen Sodium ER Placebo|Drug: Naproxen Sodium IR Placebo Bayer Phase 3 2011-06-01 2015-08-12
    NCT00792636 Migraine Disorders Drug: sumatriptan and naproxen sodium combination tablet|Drug: sumatriptan tablet|Drug: naproxen sodium tablet GlaxoSmithKline Phase 4 2008-11-01 2016-10-11
    NCT00818415 Pain Drug: Naproxen sodium ER (BAYH6689)|Drug: Commercial Naproxen (Aleve, BAYH6689) Bayer Phase 1 2008-11-01 2014-05-16
    NCT00586365 Heterotopic Ossification Drug: Naproxen Massachusetts General Hospital Phase 4 2007-10-01 2012-03-20
    NCT01495858 Pain, Postoperative Drug: Naproxen Sodium 440 mg / DPH 25 mg (BAY98-7111)|Drug: Naproxen Sodium 440 mg (BAYH6689)|Drug: DPH 50 mg Bayer Phase 3 2011-12-01 2015-05-13
    NCT00720057 Toothache Drug: Naproxen Sodium ER (BAYH6689)|Drug: Placebo Bayer Phase 3 2008-06-01 2015-08-12
    NCT03092193 Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant|Poor Metabolizer Due to Cytochrome p450 CYP2C19 Variant Drug: Naproxen|Drug: Naproxen-esomeprazole University of Sao Paulo|Fundao de Amparo Pesquisa do Estado de So Paulo Phase 4 2017-03-01 2017-03-24
    NCT00966641 Healthy Volunteers Drug: Naproxen|Drug: PL 3100 PLx Pharma|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Phase 1|Phase 2 2009-08-01 2015-08-06
    NCT01280591 Pain, Postoperative Drug: Naproxen sodium 440 mg / DPH 50 mg (BAY98-7111)|Drug: Naproxen sodium 220 mg / DPH 50 mg (BAY98-7111)|Drug: Naproxen sodium 440 mg (BAYH6689)|Drug: DPH 50 mg Bayer Phase 3 2010-10-01 2015-05-13
    NCT02494856 Pain|Other Surgical Procedures|Impacted Third Molar Tooth Drug: Surgery with Naproxen|Drug: Surgery with Naproxen and Esomeprazole Giovana Maria Weckwerth|Fundao de Amparo Pesquisa do Estado de So Paulo|University of Sao Paulo Phase 4 2014-10-01 2016-11-03
    NCT02702817 Alzheimer Disease|Cognitive Decline Due to Alzheimer Disease|Mild Cognitive Impairment Due to Alzheimer Disease Drug: Naproxen|Drug: Placebo Douglas Mental Health University Institute|McGill University|Johns Hopkins University Phase 2 2012-08-01 2016-03-03
    NCT02229461 Hematology Drug: Naproxen Sodium (Aleve, BAY117031)|Drug: Acetylsalicylic Acid (Aspirin, BAYE4465) Bayer Phase 1 2015-02-01 2016-06-16

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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