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Tenofovir Disoproxil Fumarate

富马酸替诺福韦二吡呋酯,GS-1278 Disoproxil Fumarate

Tenofovir Disoproxil FumarateDisoproxil Fumarate能阻断HIV-1和HBV的逆转录酶，对HIV-1和HIV-2的IC50分别为0.5-2.2 uM和1.6-4.9 uM。

目录号
EY0893
EY0893
EY0893
纯度
99.63%
99.63%
99.63%
规格
5 mg
10 mg
50 mg
原价
200
300
800
售价
200
300
800
库存
现货
现货
现货
订购
订购
订购
订购
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  • 生物活性

    Tenofovir Disoproxil Fumarate belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Ray AS, et al. Antimicrob Agents Chemother, 2006, 50(10), 3297-3304.
    [2] DeChristoforo R, Penzak SR. Tenofovir: a nucleotide analogue reverse-transcriptase inhibitor for treatment of HIV infection. Am J Health Syst Pharm. 2004 Jan 1;61(1):86-98; quiz 99-100.
    [3] Menne S, Cote PJ, Korba BE, Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2005 Jul;49(7):2720-8.

    分子式
    C23H34N5O14P    		 分子量
    635.51    		 CAS号
    202138-50-9    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    128 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    44 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02533544 Chronic Hepatitis B Drug: tenofovir disoproxil fumarate Myeong Jun Song|Gilead Sciences|Wonkwang University|Soonchunhyang University Hospital|Chungnam National University Hospital|Konyang University Hospital|The Catholic University of Korea 2015-10-01 2016-06-01
    NCT02195518 Hepatitis B, Chronic Drug: Tenofovir disoproxil fumarate GlaxoSmithKline Phase 4 2015-03-01 2016-08-03
    NCT00648817 HIV Infections Drug: Tenofovir Disoproxil Fumarate|Drug: Tenofovir DF placebo Gilead Sciences Phase 4 2006-07-01 2008-03-31
    NCT02589457 Chronic Hepatitis B Drug: CKD-390|Drug: Viread tablet Chong Kun Dang Pharmaceutical Phase 1 2015-10-01 2016-01-11
    NCT02463019 Chronic Hepatitis B|Antiviral Treatment Drug: Tenofovir Disoproxil Fumarate E-DA Hospital|Taipei Institute of Pathology Phase 4 2015-01-01 2015-06-02
    NCT01671787 Chronic Hepatitis B Drug: GS-7340|Drug: Tenofovir disoproxil fumarate Gilead Sciences Phase 1 2012-03-01 2014-05-08
    NCT00734162 Hepatitis B Virus (HBV) Drug: Tenofovir disoproxil fumarate (TDF)|Drug: Placebo Gilead Sciences Phase 3 2008-12-01 2016-07-20
    NCT03070405 Healthy Volunteers Drug: Tenofovir disoproxil fumarate 300mg|Drug: Para-aminosalicylic acid Ca granule 5.28 g Inje University Phase 1 2016-10-01 2017-03-02
    NCT01334567 Hepatitis B Drug: Tenofovir DF Gilead Sciences Phase 2 2010-08-01 2014-02-28
    NCT02280109 Healthy|HIV Drug: Tenofovir Gel|Drug: Tenofovir Film CONRAD|National Institute of Allergy and Infectious Diseases (NIAID) Early Phase 1 2014-11-01 2016-01-27
    NCT02557594 Healthy Drug: Viread 300mg|Drug: DA-2802 319mg Dong-A ST Co., Ltd. Phase 1 2015-10-01 2015-09-22
    NCT02995005 Hepatitis B Drug: Tenofovir Disoproxil Fumarate Johns Hopkins Bloomberg School of Public Health|Thrasher Research Fund|Shoklo Malaria Research Unit|Chiang Mai University Phase 1|Phase 2 2017-08-01 2017-02-28
    NCT02530060 Healthy Drug: Rilpivirine/Tenofovir Disoproxil Fumarate/Emtricitabine FDC Janssen Pharmaceutical K.K. Phase 4 2015-08-01 2016-12-30
    NCT02510963 Hepatitis B, Chronic Drug: Tenofovir Disoproxil Fumarate|Drug: Tenofovir Disoproxil Fumarate|Drug: Tenofovir Disoproxil Fumarate First Affiliated Hospital Xi'an Jiaotong University 2015-11-01 2016-08-09
    NCT02479880 Hepatitis B Drug: Tenofovir DF|Radiation: DEXA Scan Gilead Sciences Phase 4 2015-07-01 2017-01-12
    NCT00736190 Chronic Hepatitis B Drug: Tenofovir disoproxil fumarate Gilead Sciences Phase 4 2008-08-01 2011-11-30
    NCT01711567 Chronic Hepatitis B Drug: tenofovir|Drug: entecavir Korea University|Gilead Sciences Phase 4 2013-04-01 2016-11-08
    NCT01872988 Chronic Hepatitis B|Hepatocellular Carcinoma Drug: Tenofovir|Drug: Placebo Taichung Veterans General Hospital|Gilead Sciences|Taipei Institute of Pathology Phase 3 2012-09-01 2014-09-03
    NCT03032536 Hepatitis B|Chronic Hepatitis B|Viral Hepatitis B Drug: AL-3778|Drug: Entecavir|Drug: Tenofovir disoproxil fumarate Alios Biopharma Inc. Phase 1 2017-01-31 2017-02-09
    NCT00507507 Chronic Hepatitis B Drug: Tenofovir DF|Drug: FTC|Drug: Placebo Gilead Sciences Phase 2 2007-09-01 2015-07-07
    NCT00903084 HIV Drug: Tenofovir Disoproxil Fumarate Public Health Foundation Enterprises, Inc.|National Institute of Mental Health (NIMH) Phase 1 2009-06-01 2015-04-02
    NCT01522625 Chronic Hepatitis B Drug: tenofovir disoproxil fumarate 300mg per day|Drug: Placebo E-DA Hospital|Gilead Sciences|Taipei Institute of Pathology Phase 4 2012-01-01 2017-03-20
    NCT01491295 Chronic Hepatitis B Drug: Tenofovir disoproxil fumarate|Drug: Lamivudine plus adefovir Taipei Veterans General Hospital, Taiwan|Kaohsiung Medical University Chung-Ho Memorial Hospital|China Medical University Hospital|Chi Mei Medical Hospital|Chiayi Christian Hospital Phase 4 2012-09-01 2016-03-31
    NCT02722343 HIV Drug: Tenofovir intravaginal ring|Drug: Truvada CONRAD|Eastern Virginia Medical School|University of North Carolina|Agility Clinical, Inc. Phase 1 2016-04-01 2016-09-01
    NCT01074645 Acute on Chronic Liver Failure|Hepatitis B Drug: Tenofovir disoproxil fumarate (TDF) Govind Ballabh Pant Hospital Phase 4 2007-11-01 2010-02-23

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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