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Amitriptyline HCl

盐酸阿米替林

Amitriptyline HCl 是一种三环抗抑郁药，抑制5-羟色胺受体，去甲肾上腺素受体， 5-HT4， 5-HT2和sigma 1受体。

目录号
EY0858
EY0858
EY0858
纯度
99.39%
99.39%
99.39%
规格
50 mg
100 mg
500 mg
原价
180
280
400
售价
180
280
400
库存
现货
现货
现货
订购
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  • 生物活性

    Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Vaishnavi SN, et al. Biol Psychiatry, 2004, 55(3), 320-322.
    [2] Sawynok et al (2001) Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. J.Psychiatry Neurosci. 26 21.
    [3] Ghelardini et al (2000) Antinociception induced by amitriptyline and imipramine is mediated by α2A-adrenoceptors. Jpn.J.Pharmacol. 82 130.
    [4] Sanchez and Hyttel (1999) Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell.Mol.Neurobiol. 19 467.

    分子式
    C20H24ClN    		 分子量
    313.86    		 CAS号
    549-18-8    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    65 mg/mL    		 Water
    15 mg/mL    		 Ethanol
    65 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02256943 Chronic Pain Drug: Amitriptyline|Drug: Tolterodine University Hospital Inselspital, Berne|University of Washington|Ludwig-Maximilians - University of Munich|Aalborg University Phase 4 2014-11-01 2016-04-05
    NCT02256956 Chronic Pain Drug: Amitriptyline|Drug: Tolterodine University Hospital Inselspital, Berne|University of Washington|Aalborg University|Ludwig-Maximilians - University of Munich Phase 4 2014-11-01 2016-04-05
    NCT02256878 Healthy Drug: BIRT 2584 XX|Drug: Amitriptyline Boehringer Ingelheim Phase 1 2004-08-01 2014-10-02
    NCT01856270 Brain Injuries|Post-Traumatic Headache Drug: Amitriptyline University of Washington Phase 2 2013-04-01 2016-05-20
    NCT01566825 Healthy Subjects Drug: Amitriptyline|Drug: Placebo Dieter Kunz, MD|Charite University, Berlin, Germany 2008-08-01 2012-03-27
    NCT02519400 Depression Drug: Amitriptyline Asan Medical Center Phase 1 2015-08-01 2015-08-09
    NCT01561209 Neck Pain Drug: Amitryptiline|Drug: Placebo St Joseph University, Beirut, Lebanon Phase 4 2012-03-01 2014-06-09
    NCT01014520 Herniated Disc|Intervertebral Disc Displacement Drug: Gabapentin , Amitriptyline Tabriz University Phase 2 2009-05-01 2009-11-16
    NCT02090998 Transformed Migraine|Chronic Daily Headache Procedure: SPG Block with 5% Lidocaine gel|Drug: Amitriptyline Rutgers, The State University of New Jersey Phase 4 2014-05-01 2016-12-13
    NCT00471445 Neurotoxicity|Pain|Peripheral Neuropathy|Unspecified Adult Solid Tumor, Protocol Specific Drug: ketamine/amitriptyline NP-H cream|Other: placebo Gary Morrow|National Cancer Institute (NCI)|University of Rochester Phase 3 2007-10-01 2015-10-13
    NCT00766350 Fibromyalgia Drug: amitriptyline|Drug: quetiapine Universidad de Granada|AstraZeneca|Hospital Clinico Universitario San Cecilio Phase 4 2008-11-01 2014-12-01
    NCT00740571 Cancer|Neuralgia Drug: amitriptyline|Drug: pregabalin Radboud University|Erasmus Medical Center|Universiteit van Amsterdam Phase 3 2008-09-01 2009-02-04
    NCT00564525 Functional Gastrointestinal Disorders Drug: Amitriptyline|Drug: Placebo Ann & Robert H Lurie Children's Hospital of Chicago|American College of Gastroenterology Phase 4 2002-10-01 2007-11-27
    NCT02552225 Laryngeal Diseases Drug: Amitriptyline|Other: Placebo Boston Medical Center|American Laryngological Association Phase 2|Phase 3 2016-04-01 2016-10-07
    NCT00515229 Cystic Fibrosis|Infection|Pseudomonas Aeruginosa Drug: amitriptyline University Hospital Tuebingen Phase 2 2006-10-01 2007-08-10
    NCT02190526 Diarrhea- Predominant Irritable Bowel Syndrome|Quality of Life Drug: Mesalazine(asacol 800 mg)|Drug: Amitriptyline|Drug: placebo like asacol|Drug: placebo like amitriptyline Tehran University of Medical Sciences|Tillotts Pharma AG Phase 4 2014-09-01 2016-04-14
    NCT00124306 Bladder Diseases|Interstitial Cystitis Drug: Amitriptyline|Other: Placebo National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|University of Pennsylvania Phase 3 2005-02-01 2013-10-28
    NCT01206478 Chronic Oral Food Refusal Drug: Amitriptyline|Drug: Placebo|Drug: Megestrol Ann Davis, PhD, MPH, ABPP|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|University of Kansas Medical Center Phase 2 2010-08-01 2016-07-01
    NCT02434523 Laryngeal Diseases|Chronic Laryngeal Neuropathy Drug: Amitriptyline|Other: Placebo Boston Medical Center|American Laryngological Association Phase 2|Phase 3 2013-09-01 2016-10-07
    NCT00000817 HIV Infections|Peripheral Nervous System Disease Drug: Amitriptyline hydrochloride|Drug: Amitriptyline hydrochloride placebo|Procedure: Point acupuncture National Institute of Allergy and Infectious Diseases (NIAID) 1994-11-01 2013-09-28
    NCT02638870 Irritable Bowel Syndrome Drug: Amitriptyline Samsung Medical Center 2016-01-01 2015-12-23
    NCT00189059 Chronic Neuropathic Pain Drug: amitriptyline UMC Utrecht|Utrecht University Phase 4 2002-10-01 2005-09-12

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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