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Floxuridine

氟尿苷,氟尿核苷,NSC-27640,Deoxyfluorouridine,FDUR,NSC27640,NSC 27640,

Floxuridine (氟脲苷; 5-fluorodeoxyuridine)为抗代谢剂，可抑制PEPT1，GI50为5.1 μM。

目录号
EY0856
EY0856
EY0856
纯度
99.43%
99.43%
99.43%
规格
100 mg
200 mg
500 mg
原价
950
1400
2800
售价
950
1400
2800
库存
现货
现货
现货
订购
订购
订购
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  • 生物活性

    Floxuridine is an antineoplastic antimetabolite, used in the treatment of colon carcinoma and colorectal cancer that has metastasized to the liver.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Tsume Y, et al. Mol Pharm, 2008, 5(5), 717-727.
    [2] Huehls et al (2012) Poly(ADP-ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells. Cancer Res. 71 4944.
    [3] Bapat et al (1983) Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides. J.Biol.Chem. 258 4130.
    [4] Wyatt and Wilson (2009) Participation of DNA repair in the response to 5-fluorouracil. Cell.Mol.Life Sci. 66 788.

    分子式
    C9H11FN2O5    		 分子量
    246.19    		 CAS号
    50-91-9    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    48 mg/mL    		 Water
    50 mg/mL    		 Ethanol
    10 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01749397 Stage IV Fallopian Tube Cancer|Stage IV Ovarian Cancer|Stage IV Primary Peritoneal Cancer Drug: Floxuridine|Other: Laboratory Biomarker Analysis|Other: Pharmacological Study|Drug: Veliparib National Cancer Institute (NCI) Phase 1 2012-12-01 2017-01-31
    NCT00695201 Colon Cancer|Rectal Cancer Drug: Floxuridine, Oxaliplatin, CPT-11|Drug: Floxuridine, Oxaliplatin, CPT-11 Memorial Sloan Kettering Cancer Center|University of Medicine and Dentistry of New Jersey|Rutgers, The State University of New Jersey|Sanofi Phase 1 2000-08-01 2016-09-22
    NCT00268463 Colorectal Cancer|Metastatic Cancer Drug: capecitabine|Drug: floxuridine|Drug: oxaliplatin NSABP Foundation Inc|National Cancer Institute (NCI) Phase 3 2006-01-01 2013-05-10
    NCT00848783 Gastric Cancer|Gastric Adenocarcinoma|Esophageal Cancer Drug: Irinotecan|Drug: Cisplatin|Procedure: Surgery|Drug: Floxuridine|Drug: Capecitabine New York University School of Medicine Phase 2 2008-05-01 2016-06-17
    NCT00063960 Colorectal Cancer|Metastatic Cancer Drug: floxuridine|Drug: irinotecan hydrochloride Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) Phase 2 2003-08-01 2016-07-01
    NCT00361842 Colorectal Neoplasms Drug: CPX-1 (Irinotecan HCl:Floxuridine) Liposome Injection Celator Pharmaceuticals Phase 2 2006-07-01 2016-07-25
    NCT00001576 Colorectal Neoplasm|Liver Neoplasm|Neoplasm Metastasis Drug: Melphalan|Drug: Floxuridine|Drug: Leucovorin National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) Phase 1 1997-07-01 2008-03-03
    NCT00005860 Cancer Drug: floxuridine|Drug: leucovorin calcium|Drug: oxaliplatin Memorial Sloan Kettering Cancer Center|National Cancer Institute (NCI) Phase 1 2000-04-01 2011-04-23
    NCT00587067 Hepatic Cancer Drug: FLOXURIDINE Memorial Sloan Kettering Cancer Center|Wake Forest University Phase 2 2003-06-01 2017-02-06
    NCT01938729 Intrahepatic Cholangiocarcinoma|Peripheral Cholangiocarcinoma|Cholangiolar Carcinoma|Cholangiocellular Carcinoma) (ICC) Procedure: Liver resection and placement of hepatic artery infusion pump|Drug: FLOXURIDINE|Drug: DEXAMETHASONE|Drug: GEMCITABINE Memorial Sloan Kettering Cancer Center|Ohio State University|University of Texas Southwestern Medical Center|Washington University School of Medicine Phase 1 2013-09-01 2016-09-09
    NCT00492999 Colorectal Cancer|Metastatic Cancer Drug: dexamethasone|Drug: floxuridine|Drug: fluorouracil|Drug: irinotecan hydrochloride|Drug: leucovorin calcium|Drug: oxaliplatin Memorial Sloan Kettering Cancer Center|National Cancer Institute (NCI) Phase 2 2007-05-01 2016-06-01
    NCT00002842 Colorectal Cancer|Metastatic Cancer Drug: floxuridine|Drug: fluorouracil|Drug: leucovorin calcium|Procedure: adjuvant therapy|Procedure: conventional surgery City of Hope Medical Center|National Cancer Institute (NCI) Phase 2 1994-09-01 2015-06-03
    NCT00003753 Colorectal Cancer|Metastatic Cancer Drug: dexamethasone|Drug: floxuridine|Drug: irinotecan hydrochloride|Procedure: adjuvant therapy|Procedure: conventional surgery Memorial Sloan Kettering Cancer Center|National Cancer Institute (NCI) Phase 2 1998-09-01 2013-06-20
    NCT00410956 Liver Cancer Biological: bevacizumab|Drug: dexamethasone|Drug: floxuridine|Genetic: protein expression analysis|Other: flow cytometry|Other: immunoenzyme technique|Other: immunohistochemistry staining method|Other: immunologic technique|Other: laboratory biomarker analysis|Procedure: dynamic contrast-enhanced magnetic resonance imaging Memorial Sloan Kettering Cancer Center|National Cancer Institute (NCI) Phase 2 2007-05-01 2016-10-24
    NCT00858338 Gastric Cancer|Stomach Cancer Procedure: Potentially curative surgery|Drug: Floxuridine (IP)|Procedure: Adjuvant Chemoradiation therapy New York University School of Medicine|Food and Drug Administration (FDA) Phase 2 2002-12-01 2016-03-10
    NCT02102789 Metastatic Colorectal Cancer Drug: mFOLFOX6|Drug: HAI Yuhong Li|Sun Yat-sen University Phase 3 2014-03-01 2015-10-28
    NCT00200200 Hepatic Metastases|Colon Cancer|Rectal Cancer Drug: Bevacizumab HAI plus systemic chemotherapy|Drug: HAI plus systemic chemotherapy Memorial Sloan Kettering Cancer Center|Mount Sinai Hospital, New York|Icahn School of Medicine at Mount Sinai Phase 2 2004-11-19 2017-02-13
    NCT00004142 Colorectal Cancer|Metastatic Cancer Drug: Floxuridine|Drug: Fluorouracil (5-FU)|Procedure: Conventional surgery|Procedure: Radiofrequency ablation M.D. Anderson Cancer Center|National Cancer Institute (NCI) Phase 2 1999-09-01 2012-07-27
    NCT00645710 Liver Metastases|Recurrent Colon Cancer|Recurrent Rectal Cancer|Stage IV Colon Cancer|Stage IV Rectal Cancer Drug: gemcitabine hydrochloride|Drug: floxuridine|Genetic: proteomic profiling|Other: matrix-assisted laser desorption/ionization time of flight mass spectrometry|Other: liquid chromatography|Radiation: yttrium Y 90 anti-CEA monoclonal antibody cT84.66|Other: laboratory biomarker analysis|Other: mass spectrometry|Other: pharmacological study City of Hope Medical Center Phase 1|Phase 2 2005-02-01 2016-11-04
    NCT01692704 Cholangiocellular Carcinoma Drug: Selective intra-arterial floxuridine and systemic gemcitabine and cisplatin University of Zurich Phase 1|Phase 2 2012-04-01 2016-03-24

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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