Levonorgestrel 是一种人工合成的孕激素,是一些激素避孕药中的活性成分。
 
            
         Levonorgestrel is a female hormone that prevents ovulation.
| 						 动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 |  | 
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
	
                      
                              [1] Sitruk-Ware et al (2006) New progestagens for contraceptive use. Hum.Reprod.Update 12 169. 
                          
                      
                      
                      
                      
                      
                      
                      
                      
                      
                   
| 分子式 C21H28O2 | 分子量 312.45 | CAS号 797-63-7 | 储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 | 
| 溶剂(常温) | DMSO 44 mg/mL | Water <1 mg/mL | Ethanol 2 mg/mL | 
体内溶解度 
| Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated | 
| HIV|Contraception | Drug: Levonorgestrel|Drug: Efavirenz | University of Nebraska|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Infectious Diseases Institute, Uganda|University of Liverpool|Feinberg School of Medicine, Northwestern University | Phase 2 | 2016-11-01 | 2016-10-24 | 
| Adenomyosis | Procedure: Placement of levonorgestrel-releasing intrauterine system | Peking Union Medical College Hospital | 2006-12-01 | 2017-01-19 | |
| Epilepsy|Contraception | Drug: levonorgestrel IUS | Columbia University|Bayer | Phase 4 | 2011-08-01 | 2015-12-14 | 
| Pregnancy, Unplanned|Pregnancy; Accident | Drug: Ulipristal acetate|Device: levonorgestrel IUS | Washington University School of Medicine|William and Flora Hewlett Foundation|University of Colorado, Denver|Planned Parenthood Federation of America|University of Rochester | 2012-12-01 | 2015-12-09 | |
| HIV|Contraception | Drug: Levonorgestrel|Drug: Nevirapine|Drug: Efavirenz | University of Nebraska|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Makerere University|University of Liverpool | Phase 2 | 2013-06-01 | 2016-03-31 | 
| Obesity | Drug: Levonorgestrel 1.5mg by mouth once | University of Southern California|Society of Family Planning | 2013-04-01 | 2016-10-24 | |
| Contraception | Drug: Levonorgestrel IUD | University of Utah|Society of Family Planning|University of New Mexico | Phase 4 | 2014-01-01 | 2017-02-02 | 
| Contraception | Device: Levonorgestrel-releasing IUD (Mirena) | University of Pittsburgh | 2007-05-01 | 2016-05-17 | |
| Emergency Contraception | Drug: Copper IUD|Drug: Levonorgestrel IUD | University of Utah | 2013-07-01 | 2016-08-04 | |
| Contraception | Drug: Levonorgestrel IUS (Mirena, BAY86-5028) | Bayer | 2007-05-01 | 2014-01-08 | |
| Healthy | Drug: levonorgestrel | FHI 360 | Phase 3 | 2010-01-01 | 2013-08-22 | 
| Endometriosis | Drug: Levonorgestrel|Drug: Etonogestrel | University of Campinas, Brazil | Phase 4 | 2015-07-01 | 2015-06-23 | 
| Contraception | Drug: LNG20|Drug: Mirena | Medicines360 | Phase 3 | 2009-11-01 | 2016-12-14 | 
| Contraceptive Implant Utilization|Lactation | Device: Jadelle|Device: Jadelle | University of California, San Francisco|Mulago Hospital, Uganda|Makerere University | Phase 4 | 2015-01-01 | 2016-07-15 | 
| Pregnancy | Drug: Copper T380 IUD|Drug: Oral levonorgestrel | University of Utah|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Society of Family Planning | 2009-10-01 | 2017-02-02 | |
| Contraception | Dietary Supplement: Placebo Control (Placebo Herb)|Dietary Supplement: St. John's Wort|Drug: Levonorgestrel | University of Utah|National Center for Complementary and Integrative Health (NCCIH) | Phase 4 | 2005-08-01 | 2015-07-15 | 
| Hyperplasia|Endometrial Cancer | Device: Levonorgestrel IUD | M.D. Anderson Cancer Center | Phase 2 | 2008-11-01 | 2016-09-07 | 
| Healthy | Device: Levonorgestrel-releasing intrauterine system (LNG-IUS)|Device: Levonorgestrel-releasing intrauterine system (LNG-IUS) | University of Chicago | 2007-05-01 | 2013-04-01 | |
| Contraception | Drug: Levonorgestrel IUS (Mirena, BAY86-5028) | Bayer | Phase 3 | 2016-12-01 | 2017-03-01 | 
| Estimating Rates of Expulsion | Device: Levonorgestrel Intrauterine Device | Maine Medical Center Research Institute | Phase 4 | 2010-08-01 | 2011-08-01 | 
| Contraception | Drug: Levonorgestrel (BAY98-7196) | Bayer | Phase 3 | 2015-05-01 | 2016-08-17 | 
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注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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