Piperacillin钠是一种半合成的广谱青霉素类抗菌剂, 肠胃用药。
Piperacillin is a semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Williamson R, et al. Antimicrob Agents Chemother, 1980, 18(4), 629-637.
分子式 C23H26N5NaO7S |
分子量 539.54 |
CAS号 59703-84-3 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 100 mg/mL |
Water 100 mg/mL |
Ethanol 100 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01760109 | Respiratory Tract Infections|Urinary Tract Infections | Drug: Piperacillin Sodium and Sulbactam Sodium | Xiangbei Welman Pharmaceutical Co., Ltd | Phase 4 | 2011-07-01 | 2012-12-30 |
NCT02466438 | Infection | Drug: Piperacillin-tazobactam | St. Justine's Hospital | Phase 1 | 2016-01-01 | 2016-04-18 |
NCT02730624 | Early Phase of Severe Sepsis and Septic Shock | Drug: Piperacillin-tazobactam | Sutep Jaruratanasirikul|Prince of Songkla University | Phase 4 | 2014-03-01 | 2016-03-31 |
NCT00703144 | Diffusive and Convective Clearance|Body Clearance|Piperacillin Tazocilline Concentrations (Cmin) | Drug: piperacillin/tazobactam|Procedure: Pharmacokinetic | University Hospital, Toulouse | Phase 4 | 2008-06-01 | 2013-01-23 |
NCT01897831 | Respiratory Tract Infections|Urinary Tract Infections | Drug: xin te mie | Xiangbei Welman Pharmaceutical Co., Ltd | Phase 4 | 2011-08-01 | 2013-07-09 |
NCT02753946 | Urinary Tract Infection Symptomatic|Acute Pyelonephritis|Urinary Tract Infection Complicated | Drug: ZTI-01|Drug: Piperacillin-tazobactam | Zavante Therapeutics|Medpace, Inc. | Phase 2|Phase 3 | 2016-04-01 | 2017-01-12 |
NCT01198925 | Infectious Disease | Drug: piperacillin continuous infusion|Drug: piperacillin extended infusion | University Hospital, Ghent | Phase 4 | 2010-09-01 | 2014-12-04 |
NCT01923363 | Obesity | Drug: Piperacillin/Tazobactam Standard Dose|Drug: Piperacillin/Tazobactam High Dose | Loma Linda University | 2014-01-01 | 2016-09-13 | |
NCT02437045 | Bloodstream Infections | Drug: Meropenem|Drug: Piperacillin-tazobactam combination product | The University of Queensland | Phase 4 | 2015-04-01 | 2016-11-13 |
NCT01694069 | Cystic Fibrosis | Drug: Piperacillin-tazobactam combination product | West Virginia University | Phase 4 | 2012-09-01 | 2014-03-14 |
NCT02306928 | Septic Shock | Other: Blood draw | University of Aarhus | 2014-09-01 | 2016-02-09 | |
NCT01796717 | Nosocomial Pneumonia | Drug: C Group|Drug: E Group | Tianjin Medical University Cancer Institute and Hospital|Pfizer | Phase 2|Phase 3 | 2012-03-01 | 2016-02-14 |
NCT00389987 | Complicated Intra-Abdominal Infections | Drug: MK0826, /Duration of Treatment : 8 Weeks|Drug: Comparator : piperacillin sodium (+) tazobactam sodium /Duration of Treatment : 8 Weeks | Merck Sharp & Dohme Corp. | Phase 3 | 2001-09-01 | 2017-02-16 |
NCT01983787 | Cystic Fibrosis | University of Aarhus | Phase 4 | 2013-07-01 | 2015-11-06 | |
NCT00873327 | Sepsis | Drug: piperacillin-tazobactam | Phillip Brian Smith|Duke University | Phase 1 | 2009-10-01 | 2013-05-29 |
NCT02176122 | Bloodstream Infections | Drug: Meropenem|Drug: Piperacillin-tazobactam combination product | The University of Queensland|International Society of Chemotherapy|Australian Society for Antimicrobials|Queensland Clinical Trials & Biostatistics Centre|Australasian Society for Infectious Diseases | Phase 4 | 2014-02-01 | 2016-11-15 |
NCT01714557 | Neutropenia|Hematopoietic Stem Cell Transplantation | Drug: Piperacillin|Drug: Piperacillin-tazobactam combination product | Chinese PLA General Hospital | 2012-09-01 | 2012-10-25 | |
NCT01370616 | Infection; Diabetic Foot | Drug: Ertapenem sodium|Drug: Piperacillin/tazobactam sodium|Drug: Piperacillin/tazobactam-matching placebo|Drug: Amoxicillin/clavulunate potassium | Merck Sharp & Dohme Corp. | Phase 3 | 2011-09-01 | 2017-02-17 |
NCT00629135 | Abscess, Intra-Abdominal | Drug: Moxifloxacin/Metronidazole or Piperacillin/Tazobactam | Hannover Medical School|Bayer | Phase 3 | 2005-11-01 | 2011-06-21 |
NCT01517815 | Septic Shock | Drug: Doripenem or Piperacillin/Tazobactam|Drug: Doripenem or Piperacillin/Tazobactam | University Hospital, Montpellier | 2012-02-01 | 2016-11-28 | |
NCT00816790 | Septic Shock|Acute Renal Failure | Drug: Piperacillin/Tazobactam|Drug: Piperacillin/Tazobactam | Fraser Health | Phase 4 | 2009-01-01 | 2015-09-10 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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