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MI-2

MALT1 inhibitor

MI 2是MALT1的不可逆抑制剂,在ABCDLBCL细胞增殖抑制实验中IC50为5.84 uM。

目录号
EY0843
EY0843
EY0843
EY0843
纯度
99.25%
99.25%
99.25%
99.25%
规格
1 mg
5 mg
10 mg
50 mg
原价
460
980
1250
4600
售价
460
980
1250
4600
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor with IC50 of 5.84 μM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    ~5 μM

  • 动物实验

    25 mg/kg/天腹腔注射

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Fontan L, et al. Cancer Cell. 2012, 22(6), 812-824.

    分子式
    C19H17Cl3N4O3
    分子量
    455.72
    CAS号
    1047953-91-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    90 mg/mL
    Water
    <1 mg/mL
    Ethanol
    20 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02177994 Infection of Cesarian Section Wound Following Delivery Drug: ceftriaxone 1gm for intravenous infusion Ain Shams Maternity Hospital Phase 3 2013-09-01 2015-06-24
    NCT01808807 Cesarean Section Far Eastern Memorial Hospital 2012-12-01 2013-08-16
    NCT00835003 Respiratory Disorders|Intensive Care, Neonatal Procedure: Elective caesarean section|Procedure: Elective caesarean section Aarhus University Hospital 2009-03-01 2014-06-03
    NCT01826604 Pregnancy|Obese Device: Alexis O C-Section Retractor|Other: Control- Conventional retractors St. Louis University 2013-01-01 2016-08-09
    NCT00663650 Basal Cell Carcinoma Procedure: Permanent Section Control|Procedure: Frozen Section Control Queen's University Phase 3 2008-08-01 2011-07-11
    NCT00653367 Lung Cancer Procedure: Nerve section Rigshospitalet, Denmark 2011-12-01 2012-02-23
    NCT02479282 Natural Cesarean Section Procedure: natural cesarean section|Procedure: traditional cesarean section Ain Shams University 2015-06-01 2015-06-19
    NCT02257255 Pregnancy Procedure: Pfannenstiel cesarean section|Procedure: Misgav-Ladach cesarean section Universidade do Vale do Sapucai 2014-05-01 2015-05-27
    NCT01217567 Cesarean Section|Cicatrix Procedure: Staples left, subcuticular suture right|Procedure: Subcuticular suture left side and staples right Holbaek Sygehus|University of Copenhagen|Region Zealand 2010-03-01 2012-02-07
    NCT02902068 Hemodynamics Device: NICaS Bio Impedance Rabin Medical Center 2016-05-01 2016-09-11
    NCT03007706 Postpartum Infectious Morbidity in Cesarean Section Delivery Procedure: Women undergo cesarean section delivery Raghda Gamal Mohamed|Minia Maternity University Hospital 2017-01-01 2016-12-30
    NCT02755168 Caesarean Section Procedure: External Pop-Out Cesarean Section Assiut University Phase 2 2015-02-01 2016-04-30
    NCT02288013 Cesarean Section Procedure: Closure of uterine incision at C section Mohamed Zayed|Cairo University|Johnson & Johnson Medical Companies 2013-10-01 2016-01-26
    NCT02368769 Frozen Sections Device: During Tele-expertise Assistance Publique - H么pitaux de Paris|Agence Regionale de Sante d'Ile de France 2013-01-01 2015-12-08
    NCT02332278 Complications; Cesarean Section Procedure: Early feeding|Procedure: Late feeding Saint Thomas Hospital, Panama 2014-06-01 2015-01-04
    NCT02977871 Cesarean Section Procedure: Bladder flap Kanuni Sultan Suleyman Training and Research Hospital 2016-07-01 2016-11-30
    NCT02609217 Cesarean Section Other: Questionnaires and interviews Universitaire Ziekenhuizen Leuven 2015-11-01 2016-04-07

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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