MI 2是MALT1的不可逆抑制剂,在ABCDLBCL细胞增殖抑制实验中IC50为5.84 uM。
MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor with IC50 of 5.84 μM.
~5 μM
25 mg/kg/天腹腔注射
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Fontan L, et al. Cancer Cell. 2012, 22(6), 812-824.
分子式 C19H17Cl3N4O3 |
分子量 455.72 |
CAS号 1047953-91-2 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 90 mg/mL |
Water <1 mg/mL |
Ethanol 20 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02177994 | Infection of Cesarian Section Wound Following Delivery | Drug: ceftriaxone 1gm for intravenous infusion | Ain Shams Maternity Hospital | Phase 3 | 2013-09-01 | 2015-06-24 |
NCT01808807 | Cesarean Section | Far Eastern Memorial Hospital | 2012-12-01 | 2013-08-16 | ||
NCT00835003 | Respiratory Disorders|Intensive Care, Neonatal | Procedure: Elective caesarean section|Procedure: Elective caesarean section | Aarhus University Hospital | 2009-03-01 | 2014-06-03 | |
NCT01826604 | Pregnancy|Obese | Device: Alexis O C-Section Retractor|Other: Control- Conventional retractors | St. Louis University | 2013-01-01 | 2016-08-09 | |
NCT00663650 | Basal Cell Carcinoma | Procedure: Permanent Section Control|Procedure: Frozen Section Control | Queen's University | Phase 3 | 2008-08-01 | 2011-07-11 |
NCT00653367 | Lung Cancer | Procedure: Nerve section | Rigshospitalet, Denmark | 2011-12-01 | 2012-02-23 | |
NCT02479282 | Natural Cesarean Section | Procedure: natural cesarean section|Procedure: traditional cesarean section | Ain Shams University | 2015-06-01 | 2015-06-19 | |
NCT02257255 | Pregnancy | Procedure: Pfannenstiel cesarean section|Procedure: Misgav-Ladach cesarean section | Universidade do Vale do Sapucai | 2014-05-01 | 2015-05-27 | |
NCT01217567 | Cesarean Section|Cicatrix | Procedure: Staples left, subcuticular suture right|Procedure: Subcuticular suture left side and staples right | Holbaek Sygehus|University of Copenhagen|Region Zealand | 2010-03-01 | 2012-02-07 | |
NCT02902068 | Hemodynamics | Device: NICaS Bio Impedance | Rabin Medical Center | 2016-05-01 | 2016-09-11 | |
NCT03007706 | Postpartum Infectious Morbidity in Cesarean Section Delivery | Procedure: Women undergo cesarean section delivery | Raghda Gamal Mohamed|Minia Maternity University Hospital | 2017-01-01 | 2016-12-30 | |
NCT02755168 | Caesarean Section | Procedure: External Pop-Out Cesarean Section | Assiut University | Phase 2 | 2015-02-01 | 2016-04-30 |
NCT02288013 | Cesarean Section | Procedure: Closure of uterine incision at C section | Mohamed Zayed|Cairo University|Johnson & Johnson Medical Companies | 2013-10-01 | 2016-01-26 | |
NCT02368769 | Frozen Sections | Device: During Tele-expertise | Assistance Publique - H么pitaux de Paris|Agence Regionale de Sante d'Ile de France | 2013-01-01 | 2015-12-08 | |
NCT02332278 | Complications; Cesarean Section | Procedure: Early feeding|Procedure: Late feeding | Saint Thomas Hospital, Panama | 2014-06-01 | 2015-01-04 | |
NCT02977871 | Cesarean Section | Procedure: Bladder flap | Kanuni Sultan Suleyman Training and Research Hospital | 2016-07-01 | 2016-11-30 | |
NCT02609217 | Cesarean Section | Other: Questionnaires and interviews | Universitaire Ziekenhuizen Leuven | 2015-11-01 | 2016-04-07 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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