Home > Dehydrogenase & > Leflunomide

Leflunomide

来氟米特,来氟洛米,HWA 486,HWA-486,HWA486

Leflunomide是抗风湿化合物,是嘧啶合成抑制剂。

目录号
EY0839
EY0839
EY0839
纯度
99.14%
99.14%
99.14%
规格
50 mg
100 mg
500 mg
原价
368.00
489.00
1580.00
售价
368.00
489.00
1580.00
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD, used as an immunosuppressant agent.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Davis JP, et al. Biochemistry, 1996, 35(4), 1270-1273.
    [2] Brazelton and Morris (1996) Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide. Curr.Opin.Immunol. 8 710.
    [3] Greene et al (1995) Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide. Biochem.Pharmacol. 50 861.

    分子式
    C12H9F3N2O2
    分子量
    270.21
    CAS号
    75706-12-6
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    54 mg/mL
    Water
    <1 mg/mL
    Ethanol
    54 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02024334 Juvenile Idiopathic Arthritis Drug: Leflunomide Mashhad University of Medical Sciences Phase 4 2013-06-01 2013-12-25
    NCT00563849 Rheumatoid Arthritis Drug: Leflunomide Sanofi Phase 4 2003-05-01 2007-12-03
    NCT02703194 Immunoglobulin G4 Related Sclerosing Disease Drug: Prednisone|Drug: Leflunomide Chinese PLA General Hospital Phase 4 2016-03-01 2016-03-30
    NCT02509052 Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma Other: Laboratory Biomarker Analysis|Drug: Leflunomide|Other: Pharmacological Study City of Hope Medical Center|National Cancer Institute (NCI) Phase 1|Phase 2 2015-11-01 2016-12-23
    NCT00637819 Systemic Lupus Eythematosus (SLE) Drug: Leflunomide Sanofi Phase 2 2003-01-01 2008-03-27
    NCT01611675 Melanoma Drug: Vemurafenib|Drug: Leflunomide Massachusetts General Hospital Phase 1|Phase 2 2012-07-01 2016-09-13
    NCT01172002 Nephritis|Lupus Drug: Leflunomide|Drug: Azathioprine RenJi Hospital|Changhai Hospital|Shanghai 10th People's Hospital|Shanghai Zhongshan Hospital|The First Affiliated Hospital with Nanjing Medical University|The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School|The First Affiliated Hospital of Soochow University|Zhejiang University|Second Affiliated Hospital, School of Medicine, Zhejiang University|First Affiliated Hospital of Wenzhou Medical Univeristy|Qilu Hospital|AnHui ShengLi Hospital|First Affiliated Hospital Bengbu Medical College|The First Affiliated Hospital of Anhui Medical University 2010-03-01 2010-08-10
    NCT00579878 Rheumatoid Arthritis Drug: Leflunomide|Drug: Methotrexate-Sulfasalazine-Hydroxychloroquine|Drug: Leflunomide-Sulfasalazine-Hydroxychloroquine|Drug: Leflunomide University of Nebraska Phase 3 1999-12-01 2014-01-02
    NCT00653003 To Determine Bioequivalence Under Fed Conditions. Drug: Leflunomide|Drug: ARAVA Par Pharmaceutical, Inc.|Novum Pharmaceutical Research Services Phase 1 2003-12-01 2008-04-03
    NCT00834418 Healthy Drug: Leflunomide 20 mg Tablets|Drug: ARAVA鈩?20 mg Tablets Teva Pharmaceuticals USA Phase 1 2002-06-01 2009-09-09
    NCT01659242 Rheumatoid Arthritis Drug: Methotrexate plus sulfasalazine|Drug: Leflunomide Singapore General Hospital Phase 4 2012-07-01 2014-11-26
    NCT00280644 Arthritis, Rheumatoid Drug: Leflunomide Sanofi Phase 4 2004-04-01 2011-01-10
    NCT00802243 Bullous Pemphigoid Drug: leflunomide University Hospital, Limoges Phase 2 2007-09-01 2008-12-03
    NCT00596206 Arthritis, Rheumatoid Drug: leflunomide Sanofi Phase 3 2007-12-01 2010-10-11
    NCT00001863 Uveitis Drug: Leflunomide National Eye Institute (NEI)|National Institutes of Health Clinical Center (CC) Phase 2 1999-03-01 2008-03-03
    NCT00652665 To Determine the Bioequivalence Study Under Fasting Drug: Leflunomide|Drug: ARAVA Par Pharmaceutical, Inc.|Novum Pharmaceutical Research Services Phase 1 2003-06-01 2008-04-03
    NCT01342016 Lupus Nephritis Drug: tacrolimus capsule|Drug: tacrolimus placebo|Drug: leflunomide tablet|Drug: leflunomide placebo|Drug: prednisone Astellas Pharma Inc|Astellas Pharma China, Inc. Phase 3 2011-04-01 2014-10-15
    NCT00946686 Rheumatoid Arthritis|Psoriatic Arthritis Drug: Leflunomide 20 mg Tablets (Geneva Pharmaceutical)|Drug: Arava 20 mg Tablets (Aventis Pharmaceutical, Inc.) Sandoz Phase 1 2002-09-01 2009-07-24
    NCT01727193 Myasthenia Gravis Drug: Azathioprine|Drug: Leflunomide First Affiliated Hospital, Sun Yat-Sen University Phase 3 2012-09-01 2012-11-16

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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