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Milrinone

米力农,米利酮,二联吡啶酮,甲氰吡酮,氰双吡酮,Win 47203

Milrinone是一种有效的，选择性的磷酸二酯酶-3抑制剂，抑制FIII PDE，IC50为0.42 μM。

目录号
EY0826
EY0826
纯度
99.37%
99.37%
规格
50 mg
100 mg
原价
386
590
售价
386
590
库存
现货
现货
订购
订购
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  • 生物活性

    Milrinone is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Cone J, et al. J Cardiovasc Pharmacol, 1999, 34(4), 497-504.
    [2] Shahid et al (1991) The presence of five cyclic nucleotide phosphodiesterase isoenzyme activities in bovine tracheal smooth muscle and the functional effects of selective inhibitors. Br.J.Pharmacol. 104 471.
    [3] Tang et al (1994) Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors. Eur.J.Pharmacol. 268 105.
    [4] Alousi et al (1983) Characterization of the cardiotonic effects of milrinone, a new and potent cardiac bipyridine, on isolated tissues from several animal species. J.Cardiovasc.Pharmacol. 5 804.

    分子式
    C12H9N3O    		 分子量
    211.22    		 CAS号
    78415-72-2    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    30 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01088997 Persistent Fetal Circulation Syndrome Drug: Milrinone Lactate Children's Hospital of Philadelphia|University of Pennsylvania|Bedford Pharmaceuticals|American Medical Association|Thrasher Research Fund 2010-06-01 2016-06-02
    NCT02077010 Heart Failure|Cardiomyopathy Drug: Milrinone Vanderbilt University|Lipscomb University Phase 3 2014-07-01 2015-06-03
    NCT01841177 Congenital Heart Disease Drug: Milrinone The Hospital for Sick Children Phase 2 2013-04-01 2016-05-12
    NCT00819377 Valvular Stenosis|Valvular Insufficiency|Hypertension, Pulmonary|Coronary Artery Disease Drug: Milrinone|Drug: Normal saline Andre Denault|Heart and stoke fondation of Quebec|Organon|Canadian Anesthesiologists' Society|Montreal Heart Institute Phase 2 2009-02-01 2013-10-23
    NCT01621971 Pulmonary Hypertension|Mitral Regurgitation Drug: inhaled milrinone|Drug: intravenous milrinone Konkuk University Medical Center Phase 3 2003-01-01 2012-06-18
    NCT02951130 Congenital Diaphragmatic Hernia|Persistent Pulmonary Hypertension of the Newborn|Hypoxemic Respiratory Failure|Pulmonary Hypoplasia Drug: Milrinone|Drug: Placebo (5% Dextrose) NICHD Neonatal Research Network|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 2 2017-02-01 2016-10-28
    NCT01571037 End Stage Heart Disease|Right Ventricular Dysfunction Drug: Inhaled, nebulized, Milrinone|Drug: inhaled nebulized milrinone University of Nebraska|Thoratec Corporation Phase 1 2012-04-01 2014-02-28
    NCT02595541 Pulmonary Hypertension Drug: milrinone|Drug: Sildenafil Assiut University Phase 1|Phase 2 2015-06-01 2015-11-10
    NCT01956006 Heart Failure Drug: Milrinone The Alfred Phase 1|Phase 2 2013-10-01 2017-01-29
    NCT02098629 Myocardial Reperfusion Injury Drug: Milrinone|Drug: Esmolol|Drug: Saline Infusion Ming-He Huang|Shantou University Medical College|University of Texas Phase 1|Phase 2 2015-05-01 2015-11-20
    NCT02640846 Septic Shock|Cardiomyopathy Drug: Levosimendan|Drug: Milrinone Sahlgrenska University Hospital, Sweden Phase 4 2015-12-01 2016-02-02
    NCT02712788 Cerebral Vasospasm Drug: Milrinone|Drug: Placebo Indiana University Phase 2 2016-04-01 2016-11-08















    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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