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Sodium Picosulfate

匹可硫酸钠,匹克硫酸钠

Sodium Picosulfate能抑制水和电解质的吸收，增加它们的分泌。

目录号
EY0822
EY0822
EY0822
EY0822
纯度
99.57%
99.57%
99.57%
99.57%
规格
5 mg
10 mg
50 mg
100 mg
原价
285
478
679
1020
售价
285
478
679
1020
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
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  • 生物活性

    Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Nishikawa J, et al. Arzneimittelforschung, 1981, 31(2), 321-325.
    [2] Fioramonti, J., C. Dupuy, and L. Bueno, In vivo motility of rat colon chronically pretreated with sennosides. Pharmacology, 1993. 47 Suppl 1: p. 155-61.
    [3] Geboes, K., et al., Effects of 'contact laxatives' on intestinal and colonic epithelial cell proliferation. Pharmacology, 1993. 47 Suppl 1: p. 187-95.

    分子式
    C18H13NNa2O8S2    		 分子量
    481.41    		 CAS号
    10040-45-6    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    100 mg/mL    		 Water
    100 mg/mL    		 Ethanol
    5 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01292109 Bowel Cleanliness Drug: sodium picosulphate Ferring Pharmaceuticals 2010-12-01 2012-02-08
    NCT03074448 Bowel Preparation Device: Aquanet|Drug: Sodium Picosulfate Kaiser Clinic and Hospital Phase 3 2014-05-01 2017-03-03
    NCT01685970 Colonoscopy Drug: High volume split-dose PEG|Drug: 2 sachets of picosulfate Inje University Phase 3 2012-09-01 2012-09-14
    NCT02979223 Bowel Preperation|Sodium Picosulfate and Magnesium Citrate|Polyethylene Glycol With Ascorbic Acid Drug: sodium picosulfate and magnesium citrate, polyethylene glycol with ascorbic acid National Cancer Center, Korea Phase 2 2016-11-01 2016-12-04
    NCT01603654 Colon Cleansing for Colonoscopy Drug: sodium picosulphate magnesium citrate|Drug: low-volume PEG -ascorbic acid Ospedale L. Sacco 鈥?Polo Universitario Phase 4 2011-01-01 2012-05-21
    NCT02211911 Healthy Drug: Bisacodyl|Drug: Sodium picosulfate Boehringer Ingelheim Phase 1 2008-02-01 2014-08-07
    NCT01093274 Bowel Preparation Drug: Sodium Picosulphate|Drug: Polyethylene Glycol Rabin Medical Center 2010-03-24
    NCT00576810 Constipation Drug: sodium picosulphate Boehringer Ingelheim Phase 3 2007-10-01 2014-04-30
    NCT03017235 Bowel Preparation Drug: Sodium Picosulfate, Magnesium Oxide and Anhydrous Citric Acid Oral Solution|Drug: Sodium Picosulfate, Magnesium Oxide and Anhydrous Citric Powder Ferring Pharmaceuticals Phase 3 2017-01-01 2017-01-16
    NCT01778192 Colorectal Cancer|Colon Adenoma Drug: Polyethylene glycol|Drug: Polyethylene glycol|Drug: Sodium picosulphate with magnesium citrate|Drug: Sodium picosulphate with magnesium citrate Korea University Anam Hospital Phase 3 2012-07-01 2013-01-29
    NCT01481714 Bowel Cleansing|Colonoscopy Drug: Sodium picosulphate, magnesium oxid and citric acid|Drug: Sodium picosulphate/magnesium oxide and citric acid Infante, Javier Molina, M.D. Phase 4 2011-11-01 2011-11-28
    NCT02239692 Bowel Cleansing Drug: PICOPREP Ferring Pharmaceuticals Phase 3 2014-11-01 2016-05-17
    NCT01909219 Colon Cleansing Drug: Sodium picosulphate/magnesium Citrate Luigi Sacco University Hospital Phase 4 2012-01-01 2013-07-25
    NCT02386449 Bowel Preparation Drug: sodium picosulfate, magnesium oxide and citric acid (Picoprep庐)|Drug: mannitol|Drug: Bisacodyl Ferring Pharmaceuticals Phase 4 2015-02-01 2016-01-11
    NCT01073943 Bowel Preparation Drug: PicoPrep|Drug: HalfLytely|Drug: bisacodyl Ferring Pharmaceuticals Phase 3 2010-05-01 2012-10-23
    NCT01073930 Bowel Preparation Drug: PicoPrep|Drug: HalfLytely|Drug: bisacodyl Ferring Pharmaceuticals Phase 3 2010-05-01 2013-02-11
    NCT01065857 Subjects Undergoing a Complete Exploratory Diagnostic Colonoscopy for the First Time. Drug: Sodium picosulphate, light magnesium oxide and anhydride citric acid.|Drug: Polyethylene glycol, KCl, NaCl, sodium sulphate anhydrous and sodium bicarbonate. Laboratorios Casen-Fleet S.L.U.|Trial Form Support S.L.|Apices Soluciones S.L. Phase 3 2010-01-01 2011-04-14
    NCT01356407 Colonoscopy Drug: PICOPREP|Drug: PEG-ELS Ferring Pharmaceuticals Phase 3 2011-01-01 2012-12-17
    NCT02273141 Colorectal Cancer Drug: NER1006, Day Before-Only Dosing|Drug: SP+MS, Day Before-Only Dosing Norgine Phase 3 2014-11-01 2016-01-18
    NCT01748591 Bowel Cleanliness Ferring Pharmaceuticals 2012-05-01 2015-12-21
    NCT00312481 Colonoscopy Drug: macrogol3350 NA sulphate NACL KCL ascorbic acid NA ascorbate|Drug: NA picosulfate magnesium citrate Norgine Phase 2 2005-07-01 2007-12-12
    NCT02024022 Bowel Cleansing Process|Colonoscopy Drug: Standard approach|Drug: Individualized approach Clinical Hospital Colentina Phase 4 2014-02-01 2016-01-26
    NCT01689792 Colorectal Cancer Drug: MOVIPREP|Drug: CitraFleet Norgine Phase 4 2011-11-01 2015-03-30

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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