Daidzein是genistein的钝化类似物,是酪氨酸激酶抑制剂和雌激素受体活化剂。
Daidzein is a natural isoflavone phytoestrogen found in Leguminosae, used as a component of foods and dietary supplements.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Higashi and Ogawara (1994) Daidzein inhibits insulin- or insulin-like growth factor-1-mediated signaling in cell cycle progression of Swiss 3T3 cells. Biochim.Biophys.Acta 1221 29.
[2] Casanova et al (1999) Development effects of dietary phytoestrogens in Sprague Dawley rats and interactions of genistein and daidzein with rat estrogen receptors α and β in vitro. Toxicol.Sci. 51 236.
[3] Jing et al (1993) Differentiation of promyelocytic leukemia cells HL-60 induced by daidzein in vitro and in vivo. Anticancer Res. 13 1049.
分子式 C15H10O4 |
分子量 254.24 |
CAS号 486-66-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 46 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01270737 | Hypertension | Dietary Supplement: Whole soy (soy flour)|Dietary Supplement: daidzein|Dietary Supplement: milk powder | Chinese University of Hong Kong | 2011-03-01 | 2011-01-04 | |
NCT00951912 | Type 2 Diabetes Mellitus | Dietary Supplement: Placebo|Dietary Supplement: Daidzein|Dietary Supplement: Genistein | Sun Yat-sen University|Chinese Nutrition Society|Danone Institute International|Department of Health of Guangdong Province | 2009-08-01 | 2012-10-16 | |
NCT01556737 | Postmenopause | Dietary Supplement: High daidzein supplement|Dietary Supplement: High genistein supplement | Wageningen University | 2011-11-01 | 2012-10-30 | |
NCT00179556 | Menopausal Symptoms | Drug: Isoflavone supplement | Beth Israel Deaconess Medical Center|Nichimo - Tokyo, Japan | Phase 2|Phase 3 | 2003-06-01 | 2017-03-12 |
NCT00924339 | Familial Hypercholesterolemia | Dietary Supplement: soy protein diet|Dietary Supplement: rapeseed oil | Medical University of Vienna | 2009-09-01 | 2009-06-17 | |
NCT00661856 | Osteoporosis | Dietary Supplement: Soy protein | Creighton University|Solae, LLC | 2001-01-01 | 2008-04-17 | |
NCT00366860 | Osteoporosis|Cardiovascular Diseases | Behavioral: Soy bread | University of Michigan|Ohio State University | Phase 1 | 2004-01-01 | 2014-12-01 |
NCT00491595 | Drug Toxicity | Drug: High Dose Soy isoflavones | University of North Carolina|National Cancer Institute (NCI)|University of North Carolina, Chapel Hill | Phase 1 | 2004-03-01 | 2007-06-25 |
NCT01497977 | Low Serum Lipid Levels | Drug: phytoestrogens|Drug: phytoestrogens | American Medical Academy, Serbia | Phase 4 | 2008-09-01 | 2011-12-27 |
NCT01463436 | Cardiovascular Disease|Osteoporosis | Dietary Supplement: soy isoflavone|Dietary Supplement: control group | Trisakti University | Phase 3 | 2010-01-01 | 2011-11-01 |
NCT02309801 | Healthy | Dietary Supplement: Daidzin|Dietary Supplement: Alcohol | Parc de Salut Mar|Ministerio de Sanidad, Servicios Sociales e Igualdad | Phase 1 | 2012-07-01 | 2014-12-04 |
NCT02026518 | Irritable Bowel Disease | Dietary Supplement: Soy isoflavones|Dietary Supplement: cholecalciferol|Dietary Supplement: Placebo of soy isoflavones|Dietary Supplement: placebo of cholecalciferol | Shahid Beheshti University of Medical Sciences | Phase 4 | 2014-01-01 | 2014-11-17 |
NCT00669656 | Prostate Cancer | Drug: Prostate Health Cocktail | University of Southern California | Phase 2 | 2008-11-01 | 2015-10-24 |
NCT02174666 | Osteopenia|Osteoporosis | Dietary Supplement: Red clover extract|Dietary Supplement: Supplementation (placebo) | University of Aarhus|European Regional Development Fund|The Ministry of Science, Technology and Innovation, Denmark | 2014-06-01 | 2015-12-14 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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