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Daidzein

大豆甙元,大豆素,Isoflavone

Daidzein是genistein的钝化类似物,是酪氨酸激酶抑制剂和雌激素受体活化剂。

目录号
EY0803
EY0803
EY0803
纯度
99.28%
99.28%
99.28%
规格
500 mg
1 g
5 g
原价
420
640
1200
售价
420
640
1200
库存
现货
现货
现货
订购
订购
订购
订购
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  • 生物活性

    Daidzein is a natural isoflavone phytoestrogen found in Leguminosae, used as a component of foods and dietary supplements.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Higashi and Ogawara (1994) Daidzein inhibits insulin- or insulin-like growth factor-1-mediated signaling in cell cycle progression of Swiss 3T3 cells. Biochim.Biophys.Acta 1221 29.
    [2] Casanova et al (1999) Development effects of dietary phytoestrogens in Sprague Dawley rats and interactions of genistein and daidzein with rat estrogen receptors α and β in vitro. Toxicol.Sci. 51 236.
    [3] Jing et al (1993) Differentiation of promyelocytic leukemia cells HL-60 induced by daidzein in vitro and in vivo. Anticancer Res. 13 1049.

    分子式
    C15H10O4
    分子量
    254.24
    CAS号
    486-66-8
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    46 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01270737 Hypertension Dietary Supplement: Whole soy (soy flour)|Dietary Supplement: daidzein|Dietary Supplement: milk powder Chinese University of Hong Kong 2011-03-01 2011-01-04
    NCT00951912 Type 2 Diabetes Mellitus Dietary Supplement: Placebo|Dietary Supplement: Daidzein|Dietary Supplement: Genistein Sun Yat-sen University|Chinese Nutrition Society|Danone Institute International|Department of Health of Guangdong Province 2009-08-01 2012-10-16
    NCT01556737 Postmenopause Dietary Supplement: High daidzein supplement|Dietary Supplement: High genistein supplement Wageningen University 2011-11-01 2012-10-30
    NCT00179556 Menopausal Symptoms Drug: Isoflavone supplement Beth Israel Deaconess Medical Center|Nichimo - Tokyo, Japan Phase 2|Phase 3 2003-06-01 2017-03-12
    NCT00924339 Familial Hypercholesterolemia Dietary Supplement: soy protein diet|Dietary Supplement: rapeseed oil Medical University of Vienna 2009-09-01 2009-06-17
    NCT00661856 Osteoporosis Dietary Supplement: Soy protein Creighton University|Solae, LLC 2001-01-01 2008-04-17
    NCT00366860 Osteoporosis|Cardiovascular Diseases Behavioral: Soy bread University of Michigan|Ohio State University Phase 1 2004-01-01 2014-12-01
    NCT00491595 Drug Toxicity Drug: High Dose Soy isoflavones University of North Carolina|National Cancer Institute (NCI)|University of North Carolina, Chapel Hill Phase 1 2004-03-01 2007-06-25
    NCT01497977 Low Serum Lipid Levels Drug: phytoestrogens|Drug: phytoestrogens American Medical Academy, Serbia Phase 4 2008-09-01 2011-12-27
    NCT01463436 Cardiovascular Disease|Osteoporosis Dietary Supplement: soy isoflavone|Dietary Supplement: control group Trisakti University Phase 3 2010-01-01 2011-11-01
    NCT02309801 Healthy Dietary Supplement: Daidzin|Dietary Supplement: Alcohol Parc de Salut Mar|Ministerio de Sanidad, Servicios Sociales e Igualdad Phase 1 2012-07-01 2014-12-04
    NCT02026518 Irritable Bowel Disease Dietary Supplement: Soy isoflavones|Dietary Supplement: cholecalciferol|Dietary Supplement: Placebo of soy isoflavones|Dietary Supplement: placebo of cholecalciferol Shahid Beheshti University of Medical Sciences Phase 4 2014-01-01 2014-11-17
    NCT00669656 Prostate Cancer Drug: Prostate Health Cocktail University of Southern California Phase 2 2008-11-01 2015-10-24
    NCT02174666 Osteopenia|Osteoporosis Dietary Supplement: Red clover extract|Dietary Supplement: Supplementation (placebo) University of Aarhus|European Regional Development Fund|The Ministry of Science, Technology and Innovation, Denmark 2014-06-01 2015-12-14

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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