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Telmisartan

替米沙坦,BIBR 277,BIBR-277,BIBR277

Telmisartan 是一种血管紧张素II受体拮抗剂（ARB），用于治疗高血压。

目录号
EY0797
EY0797
EY0797
纯度
99.15%
99.15%
99.15%
规格
50 mg
100 mg
500 mg
原价
523
820
1400
售价
523
820
1400
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
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  • 生物活性

    Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Benson SC, et al. Hypertension, 2004, 43(5), 993-1002.
    [2] Rong et al (2009) An adipose tissue-independent insulin-sensitizing action of telmisartan: a study in lipodystrophic mice. J.Pharmacol.Exp.Ther. 331 1096.
    [3] Ries et al (1993) 6-substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships. J.Med.Chem. 36 4040.

    分子式
    C33H30N4O2    		 分子量
    514.62    		 CAS号
    144701-48-4    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    13 mg/mL    		 Water
    Insoluble     		Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01356017 Healthy Male Volunteers Drug: Telmisartan 80mg, S-amlodipine 5mg|Drug: Telmisartan 80mg Chong Kun Dang Pharmaceutical|Asan Medical Center Phase 1 2011-06-01 2011-09-04
    NCT02338232 GVHD Drug: Telmisartan Hackensack University Medical Center 2015-06-01 2016-12-28
    NCT01211171 Hypertension Drug: Telmisartan (Kinzal/Pritor, BAY68-9291) Bayer 2009-05-01 2014-02-11
    NCT02170246 Acute HIV Infection|HIV Infections Drug: Telmisartan Yale University|National Institute of Neurological Disorders and Stroke (NINDS)|South East Asia Research Collaboration with Hawaii|University of California, San Francisco|Walter Reed Army Institute of Research (WRAIR)|University of Hawaii|National Institute of Mental Health (NIMH) Phase 1 2014-08-01 2015-01-22
    NCT01842230 Essential Hypertension|Hyperlipidemia Drug: Telmisartan 80mg, S-amlodipine 5mg and Atorvastatin 40mg|Drug: Telmisartan 80mg and S-amlodipine 5mg Chong Kun Dang Pharmaceutical Phase 1 2013-04-01 2013-07-31
    NCT01181011 Healthy Drug: amlodipine/telmisartan/combination Boehringer Ingelheim Phase 1 2010-08-01 2014-07-15
    NCT01088295 HIV Infection Drug: Telmisartan University of California, Los Angeles|California HIV/AIDS Research Program Phase 2 2010-05-01 2014-06-19
    NCT01806363 Hypertension Drug: Telmisartan 80mg|Drug: Chlorthalidone 25mg HanAll BioPharma Co., Ltd. Phase 1 2012-11-01 2014-02-24
    NCT01578772 Endothelial Dysfunction Drug: Telmisartan University of California, Los Angeles|The Campbell Foundation Phase 2 2012-08-01 2014-12-02
    NCT02213224 Nonalcoholic Fatty Liver Disease (NAFLD) Drug: Perindopril|Drug: Telmisartan|Drug: Amlodipine Nanfang Hospital of Southern Medical University Phase 4 2014-08-01 2014-08-08
    NCT00471003 Hypertension Drug: Pritor (Telmisartan , BAY68-9291) Bayer 2006-09-01 2010-01-19
    NCT02079805 Essential Hypertension Complicated by Type 2 Diabetes Mellitus Drug: Azilsartan|Drug: Telmisartan Takeda Phase 4 2014-03-01 2016-07-26
    NCT02259816 Healthy Drug: Telmisartan|Drug: Amlodipine Boehringer Ingelheim Phase 1 2006-05-01 2014-10-06
    NCT02057328 Hypertension Drug: TELMISARTAN|Drug: NEBIVOLOL Aristotle University Of Thessaloniki Phase 4 2010-12-01 2014-02-05
    NCT01217879 Hypertension Drug: Telmisartan (Kinzal/Pritor, BAY68-9291) Bayer 2010-01-01 2012-11-14
    NCT02262559 Healthy Drug: BIBR 277 tablet|Drug: BIBR 277 capsule Boehringer Ingelheim Phase 1 2002-07-01 2014-10-09
    NCT01928927 HIV-1 Infection Drug: Telmisartan AIDS Clinical Trials Group|National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 2013-11-01 2016-05-05
    NCT01975961 Dyslipidemia & Hypertension Drug: Crestor 20mg(Rosuvastatin 20mg), Micardis 80mg(Telmisartan 80mg) , FDC Yuhan Corporation Phase 1 2013-07-01 2013-10-28
    NCT02750059 Acute HIV Infection|HIV CNS Involvement Drug: TDF/3TC/EFV + Telmisartan|Drug: TDF/3TC/EFV only South East Asia Research Collaboration with Hawaii|National Institute of Neurological Disorders and Stroke (NINDS) Phase 2 2015-01-01 2016-12-07
    NCT01683084 Abdominal Aortic Aneurysm Drug: Telmisartan|Drug: Placebo Ronald L. Dalman, MD|Palo Alto Veterans Institute for Research Phase 4 2012-09-01 2016-03-28
    NCT02047175 Hypertension|Hyperlipidemia Drug: Telmisartan/S-Amlodipine|Drug: Rosuvastatin|Drug: Telmisartan/S-Amlodipine + Rosuvastatin|Drug: Telmisartan/S-Amlodipine + Rosuvastatin Chong Kun Dang Pharmaceutical Phase 1 2014-02-01 2014-04-16
    NCT02187705 Hypertension Drug: Telmisartan tablets Boehringer Ingelheim Phase 4 1999-05-01 2014-07-10
    NCT01222520 Hypertension Drug: Telmisartan and amlodipine|Drug: Telmisartan Boehringer Ingelheim Phase 3 2010-10-01 2014-06-17
    NCT00559286 Arterial Hypertension|Diabetes Mellitus Type 2 IRC or NIR Drug: Telmisartan RWTH Aachen University|CTCA|Heidelberg University|Bayer Phase 4 2007-12-01 2009-01-28

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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