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Terbutaline Sulfate

硫酸特布他林,硫酸叔丁宁按

Terbutaline Sulfate是一种选择性的β2-肾上腺素能受体激动剂，IC50为53 nM。

目录号
EY0789
EY0789
EY0789
纯度
99.48%
99.48%
99.48%
规格
25 mg
50 mg
100 mg
原价
450
770
1100
售价
450
770
1100
库存
现货
现货
现货
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  • 生物活性

    Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Petersson BA. Allergy, 1984, 39(5), 351-357.
    [2] Mohamed Ismail NA, et al. Nifedipine versus terbutaline for tocolysis in external cephalic version. Int J Gynaecol Obstet. 2008 Sep;102(3):263-6.

    分子式
    C24H38N2O6.H2O4S    		 分子量
    548.65    		 CAS号
    23031-32-5     		储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    <1 mg/mL    		 Water
    100 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02178059 Healthy Volunteers Drug: terbutaline sulphate delivered dose|Drug: terbutaline sulphate metered dose AstraZeneca Phase 1 2014-08-01 2017-01-17
    NCT00607503 Type 1 Diabetes Drug: Terbutaline Jaeb Center for Health Research|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Phase 1 2008-02-01 2016-09-02
    NCT00914797 Asthma Drug: inhaled and oral terbutaline Bispebjerg Hospital|Hormone Laboratory, Aker University Hospital, Oslo, Norway Phase 4 2009-07-01 2009-06-04
    NCT02322788 Asthma Drug: Terbutaline sulphate|Drug: Terbutaline sulphate|Drug: Placebo for terbutaline sulphate|Drug: Placebo for terbutaline sulphate AstraZeneca Phase 3 2015-03-01 2016-11-23
    NCT00185887 Fetal Distress Drug: Terbutaline Stanford University 2003-10-01 2011-03-04
    NCT00124995 Status Asthmaticus Drug: terbutaline Connecticut Children's Medical Center Phase 4 2003-10-01 2013-02-12
    NCT01096017 Asthma Drug: Terbutaline Turbuhaler庐|Drug: Salbutamol pMDI|Other: pMDI placebo pMDI|Other: Placebo Turbuhaler庐 AstraZeneca Phase 3 2010-03-01 2012-07-27
    NCT00750568 Status Asthmaticus Wayne State University 2007-10-01 2008-09-09
    NCT02115256 External Cephalic Version Drug: Intravenous Terbutaline|Drug: Intravenous Nitroglycerine Yaakov Beilin|Icahn School of Medicine at Mount Sinai Phase 2|Phase 3 2014-07-01 2015-04-13
    NCT00989833 Exercise Induced Asthma Drug: budesonide|Drug: terbutaline|Drug: budesonide/formoterol AstraZeneca Phase 2 2009-09-01 2012-07-06
    NCT01651962 Labor Pain Drug: Terbutaline|Drug: Fentanyl|Drug: 0.9% NaCl Kai Schoenhage|University of Arizona Phase 4 2012-08-01 2015-01-15
    NCT00974051 Type 1 Diabetes Drug: Terbutaline|Other: 20% basal insulin reduction|Other: Control University of Colorado, Denver 2008-03-01 2013-08-02
    NCT00837967 Asthma Drug: Symbicort Turbuhaler|Drug: Terbutaline Turbuhaler AstraZeneca Phase 3 2009-01-01 2012-08-27
    NCT02224157 Asthma Drug: budesonide/formoterol 'as needed' + budesonide placebo bid|Drug: budesonode bid + terbutaline 'as needed' AstraZeneca Phase 3 2014-11-01 2016-12-27
    NCT02149199 Asthma Drug: budesonide/formoterol 'as needed' + budesonide placebo bid|Drug: terbutaline 'as needed' + placebo budesonide bid|Drug: budesonide bid + terbutaline 'as needed' AstraZeneca Phase 3 2014-07-01 2017-01-24
    NCT01582646 Postthoracotomy Pain|Postthoracoscopy Neuropathic Pain Drug: Terbutaline sustained release 5 mg University Hospital, Strasbourg, France Phase 2 2012-01-01 2014-09-17
    NCT00839800 Asthma Drug: Symbicort Turbuhaler|Drug: Terbutaline Turbuhaler AstraZeneca Phase 3 2009-02-01 2012-11-26
    NCT02712658 Skeletal Muscle Fatigue in Humans Drug: Terbutaline|Drug: Placebo University of Copenhagen 2015-09-01 2017-01-29
    NCT00244608 Asthma Drug: Budesonide/Formoterol Turbuhaler|Drug: Budesonide Turbuhaler (Pulmicort)|Drug: Terbutaline Turbuhaler AstraZeneca Phase 3 2005-05-01 2011-01-21
    NCT02103374 Severe Chronic Obstructive Pulmonary Disease Drug: Atrovent + Bricanyl or Atrovent + Ventoline|Drug: Placebo University Hospital, Tours Phase 4 2012-01-01 2016-04-26
    NCT00242775 Asthma Drug: Budesonide/formoterol Turbuhaler|Drug: Salmeterol/fluticasone Diskus AstraZeneca Phase 3 2005-05-01 2011-01-21
    NCT00214318 Heart Failure Drug: Terbutaline plus Metoprolol or carvedilol University of Wisconsin, Madison 2005-01-01 2015-10-06
    NCT00802230 Heart Failure Drug: Terbutaline Infusion University of Utah|GlaxoSmithKline Phase 4 2002-09-01 2008-12-03

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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