Proflavine硫酸盐是Acridine衍生物,抗细菌化合物。
Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Stokowa K, et al. J Inorg Biochem, 2012, 106(1), 111-116.
分子式 C13H11N3 |
分子量 209.25 |
CAS号 1811-28-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO <1 mg/mL |
Water 24 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02018367 | Barrett's Esophagus | Drug: Proflavine, high resolution imaging | Anandasabapathy, Sharmila, M.D.|William Marsh Rice University | Phase 1 | 2012-09-01 | 2017-01-25 |
NCT02029937 | Suspected or Known Squamous Cell Neoplasia|Prior History of Squamous Cell Dysplasia and /or Neoplasia | Drug: Proflavine, high resolution imaging | Anandasabapathy, Sharmila, M.D.|William Marsh Rice University | Phase 2 | 2014-01-01 | 2016-07-11 |
NCT01384227 | Barrett's Esophagus | Drug: Proflavine Hemisulfate | Anandasabapathy, Sharmila, M.D.|Icahn School of Medicine at Mount Sinai | Early Phase 1 | 2009-02-01 | 2016-01-08 |
NCT01384240 | Colon Polyps|Colonic Dysplasia|Anal Dysplasia | Drug: Proflavine Hemisulfate | Anandasabapathy, Sharmila, M.D. | Early Phase 1 | 2010-04-01 | 2016-01-08 |
NCT01384708 | Squamous Cell Cancer | Drug: proflavine | Anandasabapathy, Sharmila, M.D.|William Marsh Rice University | Early Phase 1 | 2010-08-01 | 2016-01-07 |
NCT01384695 | GERD|Barrett's Esophagus | Drug: Fluorescein|Drug: Proflavine hemisulfate | Anandasabapathy, Sharmila, M.D. | Early Phase 1 | 2009-06-01 | 2016-01-08 |
NCT01456143 | Squamous Cell Carcinoma|Neoplasia|Head and Neck Cancer | Device: High Resolution Microendoscopy (HRME)|Other: Proflavine hemisulfate | Sharmila Anandasabapathy, MD|William Marsh Rice University|Anandasabapathy, Sharmila, M.D. | 2011-12-01 | 2016-05-06 | |
NCT01384864 | Barrett's Esophagus|Intraepithelial Neoplasia | Drug: proflavine | Anandasabapathy, Sharmila, M.D.|William Marsh Rice University | Early Phase 1 | 2011-08-01 | 2016-01-07 |
NCT01269190 | Head and Neck Cancer | Drug: Proflavine|Procedure: Imaging|Device: Widefield Multispectral Imaging Devices|Device: High-Resolution Microendoscope (HRME) | M.D. Anderson Cancer Center|National Institutes of Health (NIH) | 2010-12-01 | 2016-08-10 | |
NCT02714439 | Malignant Neoplasms of Female Genital Organs | Drug: Proflavine|Procedure: High-Resolution Microendoscopy (HRME) | M.D. Anderson Cancer Center|University of Texas | Early Phase 1 | 2017-02-01 | 2016-11-09 |
NCT02206048 | Cervix Carcinoma | Drug: Proflavine|Procedure: High-Resolution Microendoscopy (HRME) Imaging | M.D. Anderson Cancer Center | 2015-10-01 | 2016-12-01 | |
NCT02095847 | Uterine Cancer | Procedure: High-Resolution Microendoscopy Imaging|Drug: Proflavine | M.D. Anderson Cancer Center|Ovarian Spore | Phase 2 | 2015-04-07 | |
NCT02790853 | Cancer of Head and Neck|Oral Potentially Malignant Disorders | Procedure: White Light (WL) Clinical Examination|Device: PS2.1/PS3 Imaging|Other: Proflavine Hemisulfate|Device: High-Resolution Optical System (HRME)|Procedure: Brush Biopsy|Procedure: Tissue Biopsy | M.D. Anderson Cancer Center|National Institutes of Health (NIH)|William Marsh Rice University|National Cancer Institute (NCI) | 2016-05-01 | 2016-11-30 | |
NCT02207959 | Gastric Cancer | Drug: Proflavine Hemisulphate salt|Procedure: White-light examination|Procedure: Imaging with High Resolution Microendoscope | Susana Gonzalez|William Marsh Rice University|Icahn School of Medicine at Mount Sinai | Phase 1 | 2015-01-01 | 2015-01-12 |
NCT02335372 | Cervical Cancer | Procedure: Wide-Field White Light Imaging|Drug: Acetic Acid|Drug: Proflavine Solution|Procedure: Wide-Field Fluorescence Imaging | M.D. Anderson Cancer Center | 2013-06-01 | 2017-03-08 | |
NCT02420665 | Cervical Cancer | Drug: Proflavine|Device: HRME Imaging|Behavioral: Phone Call|Procedure: Colposcopy|Drug: Acetic Acid | M.D. Anderson Cancer Center|National Cancer Institute (NCI)|National Institutes of Health (NIH) | 2015-09-01 | 2016-08-16 | |
NCT02494310 | Neoplasia of the Uterine Cervix|Cancer Prevention|Cervical Intraepithelial Neoplasia | Device: High-Resolution Microendoscopy Imaging | Barretos Cancer Hospital|William Marsh Rice University|M.D. Anderson Cancer Center|National Institutes of Health (NIH) | 2015-09-01 | 2017-02-01 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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