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Proflavin hemisulfate

Proflavine硫酸盐 3,6-Diaminoacridine hemisulfate

Proflavine硫酸盐是Acridine衍生物,抗细菌化合物。

目录号
EY0785
EY0785
纯度
99.45%
99.45%
规格
50 mg
100 mg
原价
250
485
售价
250
485
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Stokowa K, et al. J Inorg Biochem, 2012, 106(1), 111-116.

    分子式
    C13H11N3
    分子量
    209.25
    CAS号
    1811-28-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    <1 mg/mL
    Water
    24 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02018367 Barrett's Esophagus Drug: Proflavine, high resolution imaging Anandasabapathy, Sharmila, M.D.|William Marsh Rice University Phase 1 2012-09-01 2017-01-25
    NCT02029937 Suspected or Known Squamous Cell Neoplasia|Prior History of Squamous Cell Dysplasia and /or Neoplasia Drug: Proflavine, high resolution imaging Anandasabapathy, Sharmila, M.D.|William Marsh Rice University Phase 2 2014-01-01 2016-07-11
    NCT01384227 Barrett's Esophagus Drug: Proflavine Hemisulfate Anandasabapathy, Sharmila, M.D.|Icahn School of Medicine at Mount Sinai Early Phase 1 2009-02-01 2016-01-08
    NCT01384240 Colon Polyps|Colonic Dysplasia|Anal Dysplasia Drug: Proflavine Hemisulfate Anandasabapathy, Sharmila, M.D. Early Phase 1 2010-04-01 2016-01-08
    NCT01384708 Squamous Cell Cancer Drug: proflavine Anandasabapathy, Sharmila, M.D.|William Marsh Rice University Early Phase 1 2010-08-01 2016-01-07
    NCT01384695 GERD|Barrett's Esophagus Drug: Fluorescein|Drug: Proflavine hemisulfate Anandasabapathy, Sharmila, M.D. Early Phase 1 2009-06-01 2016-01-08
    NCT01456143 Squamous Cell Carcinoma|Neoplasia|Head and Neck Cancer Device: High Resolution Microendoscopy (HRME)|Other: Proflavine hemisulfate Sharmila Anandasabapathy, MD|William Marsh Rice University|Anandasabapathy, Sharmila, M.D. 2011-12-01 2016-05-06
    NCT01384864 Barrett's Esophagus|Intraepithelial Neoplasia Drug: proflavine Anandasabapathy, Sharmila, M.D.|William Marsh Rice University Early Phase 1 2011-08-01 2016-01-07
    NCT01269190 Head and Neck Cancer Drug: Proflavine|Procedure: Imaging|Device: Widefield Multispectral Imaging Devices|Device: High-Resolution Microendoscope (HRME) M.D. Anderson Cancer Center|National Institutes of Health (NIH) 2010-12-01 2016-08-10
    NCT02714439 Malignant Neoplasms of Female Genital Organs Drug: Proflavine|Procedure: High-Resolution Microendoscopy (HRME) M.D. Anderson Cancer Center|University of Texas Early Phase 1 2017-02-01 2016-11-09
    NCT02206048 Cervix Carcinoma Drug: Proflavine|Procedure: High-Resolution Microendoscopy (HRME) Imaging M.D. Anderson Cancer Center 2015-10-01 2016-12-01
    NCT02095847 Uterine Cancer Procedure: High-Resolution Microendoscopy Imaging|Drug: Proflavine M.D. Anderson Cancer Center|Ovarian Spore Phase 2 2015-04-07
    NCT02790853 Cancer of Head and Neck|Oral Potentially Malignant Disorders Procedure: White Light (WL) Clinical Examination|Device: PS2.1/PS3 Imaging|Other: Proflavine Hemisulfate|Device: High-Resolution Optical System (HRME)|Procedure: Brush Biopsy|Procedure: Tissue Biopsy M.D. Anderson Cancer Center|National Institutes of Health (NIH)|William Marsh Rice University|National Cancer Institute (NCI) 2016-05-01 2016-11-30
    NCT02207959 Gastric Cancer Drug: Proflavine Hemisulphate salt|Procedure: White-light examination|Procedure: Imaging with High Resolution Microendoscope Susana Gonzalez|William Marsh Rice University|Icahn School of Medicine at Mount Sinai Phase 1 2015-01-01 2015-01-12
    NCT02335372 Cervical Cancer Procedure: Wide-Field White Light Imaging|Drug: Acetic Acid|Drug: Proflavine Solution|Procedure: Wide-Field Fluorescence Imaging M.D. Anderson Cancer Center 2013-06-01 2017-03-08
    NCT02420665 Cervical Cancer Drug: Proflavine|Device: HRME Imaging|Behavioral: Phone Call|Procedure: Colposcopy|Drug: Acetic Acid M.D. Anderson Cancer Center|National Cancer Institute (NCI)|National Institutes of Health (NIH) 2015-09-01 2016-08-16
    NCT02494310 Neoplasia of the Uterine Cervix|Cancer Prevention|Cervical Intraepithelial Neoplasia Device: High-Resolution Microendoscopy Imaging Barretos Cancer Hospital|William Marsh Rice University|M.D. Anderson Cancer Center|National Institutes of Health (NIH) 2015-09-01 2017-02-01

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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