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Ramipril

雷米普利

Ramipril 是血管紧张素转换酶(ACE)抑制剂，IC50为5 nM。

目录号
EY0781
EY0781
纯度
99.34%
99.34%
规格
100 mg
500 mg
原价
630
1100
售价
630
1100
库存
现货
现货
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  • 生物活性

    Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    1 μM 左右

  • 动物实验

    0.03-10 mg/kg每天饲喂处理

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Stevens BR, et al. Comp Biochem Physiol C, 1988, 91(2), 493-497.
    [2] Levitt et al (2006) Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat. BMC Clin. Pharmacol. 6 1.
    [3] Tian et al (2014) Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKKß/AMPK and heme oxygenase-1 activation. J.Pharmacol.Exp.Ther. 350 5.

    分子式
    C23H32N2O5    		 分子量
    416.51    		 CAS号
    87333-19-5    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    83 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    83 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01743014 Diabetes Type 2|Diabetic Nephropathy|Vascular Disease Drug: Ramipril|Drug: Clopidogrel AHEPA University Hospital|Aristotle University Of Thessaloniki Phase 4 2012-07-01 2012-12-04
    NCT01164761 Healthy Drug: Ramipril|Drug: Altace Dr. Reddy's Laboratories Limited Phase 1 2005-09-01 2010-07-16
    NCT01164774 Healthy Drug: Ramipril|Drug: Altace Dr. Reddy's Laboratories Limited Phase 1 2005-10-01 2010-07-16
    NCT02842424 Peripheral Arterial Disease Drug: Ramipril University of Nebraska Phase 4 2015-10-01 2016-07-21
    NCT00879788 Healthy Drug: Ramipril 10mg capsules Ranbaxy Laboratories Limited|Ranbaxy Inc. 2006-10-01 2009-04-09
    NCT00574834 Metabolic Syndrome Drug: Ramipril|Drug: HCTZ-hydrochlorothiazide|Drug: Ramipril+HCTZ University of Maryland|King Pharmaceuticals is now a wholly owned subsidiary of Pfizer Early Phase 1 2007-03-01 2017-02-09
    NCT01402479 Migraine With Hypertension Drug: Ramipril Seoul National University Hospital Phase 2 2004-10-01 2011-08-05
    NCT00529451 Hypertension Drug: Aliskiren|Drug: Ramipril Novartis Phase 3 2007-09-01 2011-02-28
    NCT00879476 Healthy Drug: Ramipril 10mg capsules Ranbaxy Laboratories Limited|Ranbaxy Inc. 2007-01-01 2009-04-09
    NCT01053910 Atherosclerosis Drug: Ramipril Sanofi Phase 4 2003-10-01 2010-01-20
    NCT00864162 Healthy Drug: Ramipril10 mg Capsules, single dose|Drug: Atlace庐 10 mg capsules, single dose Actavis Inc. Phase 1 2004-09-01 2010-08-13
    NCT00864448 Healthy Drug: Ramipril10 mg Capsules, single dose|Drug: Atlace庐 10 mg capsules, single dose Actavis Inc. Phase 1 2004-10-01 2010-08-13
    NCT00863915 Healthy Drug: Ramipril10 mg Capsules, single dose|Drug: Atlace庐 10 mg capsules, single dose Actavis Inc. Phase 1 2004-10-01 2010-08-13
    NCT01856361 Oligospermia|Teratospermia|Asthenozoospermia|Male Infertility Drug: Ramipril|Drug: Placebo Weill Medical College of Cornell University 2013-07-01 2013-09-05
    NCT00473174 Hypertension Drug: Ramipril|Device: ambulatory blood pressure monitoring University of Vigo|King Pharmaceuticals is now a wholly owned subsidiary of Pfizer Phase 4 2007-03-01 2009-09-01
    NCT00631917 Hypertension Drug: Aliskiren|Drug: Ramipril|Other: Placebo to Ramipril|Other: Placebo to Aliskiren Novartis Phase 4 2008-02-01 2011-06-30
    NCT00389519 Hypertension Drug: ramipril|Drug: placebo Pfizer Phase 3 2006-10-01 2012-06-06
    NCT02729441 Diabetes|Microalbuminuria Drug: ramipril|Drug: perindopril Sunnybrook Health Sciences Centre|Servier Phase 3 2010-04-01 2016-03-31
    NCT01037530 Intermittent Claudicants Drug: Ramipril Daniel Carradice|University of Hull Phase 4 2010-12-01 2014-12-18
    NCT00772577 Hypertension Drug: Aliskiren Hydrochlorothiazide|Drug: Ramipril Novartis Phase 4 2008-08-01 2011-03-08
    NCT00542269 Hypertension With Metabolic Syndrome Drug: Amlodipine|Drug: Aliskiren|Drug: Ramipril Novartis Phase 4 2008-03-01 2011-04-26
    NCT01042392 Essential Hypertension Drug: Aliskiren|Drug: Ramipril|Drug: Matching placebo to Aliskiren|Drug: Matching placebo to Ramipril Novartis Phase 4 2009-11-01 2012-03-06
    NCT00657865 Healthy Drug: ramipril|Drug: placebo Medical University of Vienna Phase 4 2008-03-01 2011-08-19

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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