ATP二钠盐是P2嘌呤受体激动剂。
ATP is a disodium salt form of adenosine-triphosphate which is a multifunctional nucleoside triphosphate.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Chen Y, et al. Science,?006, 314(5806), 1792-1795.
[2] Guilbert et al (1998) Dependence of P2-nucleotide receptor agonist-mediated endothelium-indepdent relaxation on ectonucleotidase acticity and A2A-receptors in rat portal vein. Br.J.Pharm. 123 1732.
[3] Burnstock and Kenned (2006) Historical review: ATP as a neurotransmitter. Trends Pharm.Sci. 27 16.
[4] Gordon (1986) Extracellular ATP: effects, sources and fate. Biochem.J 233 309.
分子式 C10H14N5Na2O13P3 |
分子量 551.14 |
CAS号 987-65-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO <1 mg/mL |
Water 106 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02923726 | Sudden Cardiac Death | Device: Arm 1 (ATP+Shock)|Device: Arm 2 (shock only) | Boston Scientific Corporation|ICON plc | 2016-09-01 | 2016-10-04 | |
NCT02093611 | Muscle Fatigue Caused by Repetitive Muscle Exercise | Dietary Supplement: Placebo|Dietary Supplement: ATP | Metabolic Technologies Inc.|University of Tampa | 2013-07-01 | 2015-09-24 | |
NCT02279511 | Alzheimer's Disease | Drug: ADENOSINE TRIPHOSPHATE|Drug: PLACEBO | Sara Varea|Fundacion Clinic per a la Recerca Biom茅dica | Phase 2 | 2014-11-01 | 2016-05-25 |
NCT00147277 | Tachycardia, Ventricular|Ventricular Fibrillation | Device: Implantable Cardiac Defibrillator | Medtronic Bakken Research Center | Phase 4 | 2004-03-01 | 2015-08-12 |
NCT00617578 | Ventricular Tachycardia, Monomorphic | Device: ATP One Shot ON|Device: ATP One Shot OFF | Biotronik SE & Co. KG | Phase 4 | 2007-11-01 | 2013-12-18 |
NCT00147290 | Tachycardia, Ventricular|Ventricular Fibrillation | Device: Implantable Cardiac Defibrillator | Medtronic Bakken Research Center | Phase 4 | 2004-02-01 | 2015-08-12 |
NCT01508338 | Healthy Experienced Weight Training Males | Dietary Supplement: Placebo|Dietary Supplement: HMB|Dietary Supplement: Peak ATP and HMB|Dietary Supplement: ATP | Metabolic Technologies Inc.|University of Tampa | 2012-01-01 | 2014-03-17 | |
NCT00917696 | Osteoarthritis Pain | Procedure: Comparator: Iontophoresis and Laser Doppler with ATP|Procedure: Comparator: Iontophoresis and Laser Doppler with Saline | Merck Sharp & Dohme Corp. | Phase 1 | 2009-10-01 | 2015-07-29 |
NCT02243631 | Calcium Pyrophosphate Deposition Disease | Drug: Probenecid | VA Office of Research and Development | Early Phase 1 | 2014-10-01 | 2017-01-04 |
NCT02439424 | Atrial Tachyarrhythmia|Atrial Fibrillation | Device: Reactive ATP | Hartford Hospital | Phase 1|Phase 2 | 2015-12-01 | 2016-12-21 |
NCT00565188 | Cancer|Palliative Care|Survival|Quality of Life | Drug: Adenosine 5'-triphosphate | Maastricht University Medical Center|ZonMw: The Netherlands Organisation for Health Research and Development | Phase 3 | 2002-03-01 | 2016-10-24 |
NCT01499069 | Overactive Bladder | Drug: Oxybutinin, Fesoterodine, Solifenacin, Propiverin, Trospium | Samsung Medical Center|Samsung Biomedical Research Institute | 2010-02-01 | 2015-02-12 | |
NCT00159315 | Asthma|COPD|Smoking | Procedure: Inhalation Challenge with ATP|Procedure: Inhalation Challenge with AMP | Imperial College London|Duska Scientific Co. | 2002-10-01 | 2015-06-03 | |
NCT01130428 | Osteoporosis | Device: Juvent 1000 Vibration Platform | Maastricht University Medical Center|Research Center for Ageing and Osteoporosis, Copenhagen University Hospital, Copenhagen, Denmark.|University of Sheffield | Phase 1|Phase 2 | 2010-10-01 | 2011-04-19 |
NCT01169246 | Ventricular Arrythmias | LivaNova|Sorin Group France SAS | 2009-11-01 | 2015-02-23 | ||
NCT00608894 | Autoimmune Hepatitis | Drug: LCP-Tacro (tacrolimus)|Drug: Azathioprine | Veloxis Pharmaceuticals | Phase 2 | 2007-12-01 | 2014-12-18 |
NCT00618267 | Multiple Sclerosis | Biogen|Elan Pharmaceuticals | 2008-03-01 | 2010-03-04 | ||
NCT01242319 | Hypercholesterolemia|Coronary Disease|Primary Health Care|Management, Risk | Behavioral: HeartAge intervention | Memorial Hospital of Rhode Island|National Heart, Lung, and Blood Institute (NHLBI) | 2002-09-01 | 2010-11-16 | |
NCT01141504 | Healthy Subjects | Dietary Supplement: PeakATP 250|Dietary Supplement: Placebo|Dietary Supplement: PeakATP 400|Dietary Supplement: PeakATP 400 plus proprietary blend | Metabolic Technologies Inc.|Iowa State University | Phase 1 | 2010-06-01 | 2012-01-09 |
NCT03002038 | Neuromyelitis Optica Spectrum Disorder | Drug: Azathioprine|Drug: Rituximab | Isfahan University of Medical Sciences | Phase 2|Phase 3 | 2015-09-01 | 2016-12-30 |
NCT00098111 | Crohn's Disease | Drug: azathioprine | Massachusetts General Hospital | Phase 3 | 2005-04-01 | 2014-02-19 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
相关化合物库
使用AMQUAR产品发表文献后请联系我们