Serotonin HCl

盐酸5-羟色胺,5-HT HCl

Serotonin HCl是一种单胺类神经递质和内源性5-HT受体激动剂。

目录号
EY0776
EY0776
EY0776
纯度
99.27%
99.27%
99.27%
规格
10 mg
50 mg
500 mg
原价
200
400
2000
售价
200
400
2000
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Serotonin HCl is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Onken, H, et al. J Insect Sci, 2008, 8, 1-20.
    [2] Barnes and Sharp (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38 1083.

    分子式
    C10H12N2O.HCl
    分子量
    212.68
    CAS号
    153-98-0
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    100 mM
    Water
    15 mg/mL
    Ethanol
    5 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02473783 Major Depressive Disorder Drug: Sertraline HCl|Other: I-123-ADAM SPECT Tri-Service General Hospital|Institute of Nuclear Energy Research, Taiwan Phase 2 2011-10-01 2015-06-16
    NCT01275248 Obsessive-compulsive Disorder Drug: Ondansetron|Drug: Placebo Transcept Pharmaceuticals Phase 2 2011-01-01 2013-01-16
    NCT01296802 Amphetamine-Related Disorders|Amphetamine Abuse Drug: dexfenfluramine University of Zurich 2006-04-01 2011-12-14
    NCT02015546 Major Depressive Disorder (MDD) Drug: Vilazodone Duke University Phase 3 2012-12-01 2015-03-25
    NCT03041870 Healthy Volunteers Device: PET-fMRI scan Hospices Civils de Lyon 2017-02-01 2017-02-02
    NCT00735670 Spinal Cord Injury Drug: Venlafaxine HCl|Other: Placebo University of Michigan|U.S. Department of Education 2008-06-01 2016-10-07
    NCT02393612 Peripheral Arterial Disease Drug: DP-R202|Drug: Anplag tab Alvogen Korea Phase 3 2012-10-01 2016-10-31
    NCT01425827 Pain Reduction|Function Improvement Drug: duloxetine HCL|Drug: placebo Faculty of Medicine, University of Alexandria 2010-11-01 2011-08-27
    NCT02186366 Anxiety Disorders Other: Abdominal Massage Therapy|Drug: Buspirone Sun Qing|First Teaching Hospital of Tianjin University of Traditional Chinese Medicine 2014-09-01 2014-09-01
    NCT02359513 Bulimia Nervosa Drug: Antidepressants|Drug: Positron Emission Tomography (PET) Centre Hospitalier Universitaire de Saint Etienne|Ministry of Health, France Phase 4 2015-11-01 2016-09-13
    NCT00167856 Neuropathic Pain|Pain|Spinal Cord Injuries Drug: Venalafaxine hydrochloride VA Office of Research and Development 2005-06-01 2014-03-26
    NCT00967499 Postoperative Nausea and Vomiting Drug: ondansetron|Drug: palonosetron Eisai Inc. Phase 2 2009-07-01 2010-05-06
    NCT00549718 Schizophrenia Drug: Lurasidone HCl Sunovion Phase 3 2007-10-01 2014-06-05
    NCT01074073 Schizophrenia Drug: Lurasidone HCl Sunovion Phase 1 2008-08-01 2011-09-06
    NCT02655991 Stress Disorders, Post-Traumatic Behavioral: Telephone Case Monitoring|Behavioral: Treatment as Usual VA Palo Alto Health Care System|Durham VA Medical Center|VA Puget Sound Health Care System 2008-03-01 2016-01-12
    NCT00711269 Schizophrenia Drug: SM-13496 (lurasidone HCl)|Drug: SM-13496 (lurasidone HCl)|Drug: Placebo|Drug: Risperidone Sumitomo Dainippon Pharma Co., Ltd. Phase 3 2008-07-01 2012-06-11
    NCT01082263 Schizophrenia Patients Drug: Lurasidone HCl Sunovion Phase 1 2008-10-01 2011-09-06
    NCT00653419 To Determine Bioequivalence Under Fasting Conditions Drug: buspirone HCl|Drug: Buspar Par Pharmaceutical, Inc.|Phoenix International Life Sciences, Inc. Phase 1 1998-06-01 2008-04-01
    NCT00615433 Schizophrenia Drug: Lurasidone|Drug: Olanzapine|Drug: Placebo comparator|Drug: Lurasidone 40 mg tablets Sunovion Phase 3 2008-01-01 2015-05-19
    NCT00652730 To Determine Bioequivalence Under Fed Conditions. Drug: Buspirone HCl|Drug: Buspirone HCl|Drug: Buspar Par Pharmaceutical, Inc.|Phoenix International Life Sciences, Inc. Phase 1 1998-07-01 2008-04-01

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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