Serotonin HCl是一种单胺类神经递质和内源性5-HT受体激动剂。
Serotonin HCl is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Onken, H, et al. J Insect Sci, 2008, 8, 1-20.
[2] Barnes and Sharp (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38 1083.
分子式 C10H12N2O.HCl |
分子量 212.68 |
CAS号 153-98-0 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 100 mM |
Water 15 mg/mL |
Ethanol 5 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02473783 | Major Depressive Disorder | Drug: Sertraline HCl|Other: I-123-ADAM SPECT | Tri-Service General Hospital|Institute of Nuclear Energy Research, Taiwan | Phase 2 | 2011-10-01 | 2015-06-16 |
NCT01275248 | Obsessive-compulsive Disorder | Drug: Ondansetron|Drug: Placebo | Transcept Pharmaceuticals | Phase 2 | 2011-01-01 | 2013-01-16 |
NCT01296802 | Amphetamine-Related Disorders|Amphetamine Abuse | Drug: dexfenfluramine | University of Zurich | 2006-04-01 | 2011-12-14 | |
NCT02015546 | Major Depressive Disorder (MDD) | Drug: Vilazodone | Duke University | Phase 3 | 2012-12-01 | 2015-03-25 |
NCT03041870 | Healthy Volunteers | Device: PET-fMRI scan | Hospices Civils de Lyon | 2017-02-01 | 2017-02-02 | |
NCT00735670 | Spinal Cord Injury | Drug: Venlafaxine HCl|Other: Placebo | University of Michigan|U.S. Department of Education | 2008-06-01 | 2016-10-07 | |
NCT02393612 | Peripheral Arterial Disease | Drug: DP-R202|Drug: Anplag tab | Alvogen Korea | Phase 3 | 2012-10-01 | 2016-10-31 |
NCT01425827 | Pain Reduction|Function Improvement | Drug: duloxetine HCL|Drug: placebo | Faculty of Medicine, University of Alexandria | 2010-11-01 | 2011-08-27 | |
NCT02186366 | Anxiety Disorders | Other: Abdominal Massage Therapy|Drug: Buspirone | Sun Qing|First Teaching Hospital of Tianjin University of Traditional Chinese Medicine | 2014-09-01 | 2014-09-01 | |
NCT02359513 | Bulimia Nervosa | Drug: Antidepressants|Drug: Positron Emission Tomography (PET) | Centre Hospitalier Universitaire de Saint Etienne|Ministry of Health, France | Phase 4 | 2015-11-01 | 2016-09-13 |
NCT00167856 | Neuropathic Pain|Pain|Spinal Cord Injuries | Drug: Venalafaxine hydrochloride | VA Office of Research and Development | 2005-06-01 | 2014-03-26 | |
NCT00967499 | Postoperative Nausea and Vomiting | Drug: ondansetron|Drug: palonosetron | Eisai Inc. | Phase 2 | 2009-07-01 | 2010-05-06 |
NCT00549718 | Schizophrenia | Drug: Lurasidone HCl | Sunovion | Phase 3 | 2007-10-01 | 2014-06-05 |
NCT01074073 | Schizophrenia | Drug: Lurasidone HCl | Sunovion | Phase 1 | 2008-08-01 | 2011-09-06 |
NCT02655991 | Stress Disorders, Post-Traumatic | Behavioral: Telephone Case Monitoring|Behavioral: Treatment as Usual | VA Palo Alto Health Care System|Durham VA Medical Center|VA Puget Sound Health Care System | 2008-03-01 | 2016-01-12 | |
NCT00711269 | Schizophrenia | Drug: SM-13496 (lurasidone HCl)|Drug: SM-13496 (lurasidone HCl)|Drug: Placebo|Drug: Risperidone | Sumitomo Dainippon Pharma Co., Ltd. | Phase 3 | 2008-07-01 | 2012-06-11 |
NCT01082263 | Schizophrenia Patients | Drug: Lurasidone HCl | Sunovion | Phase 1 | 2008-10-01 | 2011-09-06 |
NCT00653419 | To Determine Bioequivalence Under Fasting Conditions | Drug: buspirone HCl|Drug: Buspar | Par Pharmaceutical, Inc.|Phoenix International Life Sciences, Inc. | Phase 1 | 1998-06-01 | 2008-04-01 |
NCT00615433 | Schizophrenia | Drug: Lurasidone|Drug: Olanzapine|Drug: Placebo comparator|Drug: Lurasidone 40 mg tablets | Sunovion | Phase 3 | 2008-01-01 | 2015-05-19 |
NCT00652730 | To Determine Bioequivalence Under Fed Conditions. | Drug: Buspirone HCl|Drug: Buspirone HCl|Drug: Buspar | Par Pharmaceutical, Inc.|Phoenix International Life Sciences, Inc. | Phase 1 | 1998-07-01 | 2008-04-01 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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