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Emtricitabine

恩曲他滨,Emtriva,Coviracil,BW-1592,BW1592,BW 1592,

Emtricitabine是HIV核苷逆转录酶抑制剂（NRTI）。

目录号
EY0775
EY0775
EY0775
纯度
99.46%
99.46%
99.46%
规格
50 mg
100 mg
500 mg
原价
470
780
1200
售价
470
780
1200
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
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  • 生物活性

    Emtricitabine (FTC) is a nucleoside reverse transcriptase inhibitor that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Venhoff N, et al. Antivir Ther, 2007, 12(7), 1075-1085.
    [2] Szczech GM, Wang LH, Walsh JP, Reproductive toxicology profile of emtricitabine in mice and rabbits. Reprod Toxicol. 2003 Jan-Feb;17(1):95-108.
    [3] Borroto-Esoda K, Parkin N, Miller MD. A comparison of the phenotypic susceptibility profiles of emtricitabine and lamivudine. Antivir Chem Chemother. 2007;18(5):297-300.

    分子式
    C8H10FN3O3S    		 分子量
    247.25    		 CAS号
    143491-57-0     		储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    ≥50 mg/mL    		 Water
    ≥50 mg/mL    		 Ethanol
    ≥15 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00743340 HIV-1 Infection Drug: Emtricitabine Gilead Sciences Phase 2 2005-11-22 2017-02-21
    NCT02327689 Hepatitis B, Chronic|Fibrosis Drug: Emtricitabine plus adefovir dipivoxil Asian-Pacific Alliance of Liver Disease, Beijing|Beijing Ditan Hospital|Hebei Medical University Pharmaceutical Factory|National Health and Family Planning Commission, P.R.China Phase 4 2015-01-01 2014-12-29
    NCT02327702 Hepatitis B, Chronic|Pregnancy Drug: Emtricitabine Asian-Pacific Alliance of Liver Disease, Beijing|Beijing Ditan Hospital|Hebei Medical University Pharmaceutical Factory|National Health and Family Planning Commission, P.R.China Phase 4 2015-01-01 2014-12-29
    NCT00642291 HIV Infections Drug: Emtricitabine|Drug: Emtricitabine Gilead Sciences Phase 2 2002-11-01 2008-04-07
    NCT02327676 Hepatitis B, Chronic Drug: Emtricitabine Asian-Pacific Alliance of Liver Disease, Beijing|Beijing Ditan Hospital|Hebei Medical University Pharmaceutical Factory|National Health and Family Planning Commission, P.R.China Phase 4 2015-01-01 2014-12-29
    NCT02327715 Hepatitis B, Chronic|Pregnancy Drug: Emtricitabine Asian-Pacific Alliance of Liver Disease, Beijing|Beijing Ditan Hospital|Hebei Medical University Pharmaceutical Factory|National Health and Family Planning Commission, P.R.China Phase 4 2015-01-01 2014-12-29
    NCT02327663 Hepatitis B, Chronic Drug: Emtricitabine Asian-Pacific Alliance of Liver Disease, Beijing|Beijing Ditan Hospital|Hebei Medical University Pharmaceutical Factory|National Health and Family Planning Commission, P.R.China Phase 4 2014-12-01 2014-12-29
    NCT02530060 Healthy Drug: Rilpivirine/Tenofovir Disoproxil Fumarate/Emtricitabine FDC Janssen Pharmaceutical K.K. Phase 4 2015-08-01 2016-12-30
    NCT00474435 Tuberculosis|HIV Infections Drug: Emtricitabine/tenofovir/efavirenz African Poverty Related Infection Oriented Research Initiative|Radboud University|Kilimanjaro Christian Medical Centre, Tanzania Phase 2 2008-11-01 2010-12-16
    NCT02583464 Acquired Immunodeficiency Syndrome Drug: Tenofovir disoproxil fumarate and emtricitabine Laboratorio Elea S.A.C.I.F. y A. Phase 1 2014-09-01 2015-10-20
    NCT02104700 HIV Drug: Rilpivirine/Emtricitabine/Tenofovir Philip Grant|Rwanda Biomedical Center|Gilead Sciences|Stanford University Phase 2|Phase 3 2014-04-01 2015-07-15
    NCT00076791 HIV Infections Drug: Emtricitabine/Tenofovir disoproxil fumarate|Drug: Tenofovir disoproxil fumarate National Institute of Allergy and Infectious Diseases (NIAID)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|International Maternal Pediatric Adolescent AIDS Clinical Trials Group Phase 1 2004-03-01 2013-07-05
    NCT02211690 Human Immunodeficiency Virus Drug: dolutegravir 50 mg (one tablet daily)|Drug: emtricitabine-tenofovir 300/200 mg (one tablet daily) Andrew Carr|ViiV Healthcare Australia Pty. Ltd|St Vincent's Hospital, Sydney Phase 4 2014-08-01 2016-05-25
    NCT02578550 Healthy Drug: Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide fixed-dose combination (FDC)|Drug: Emtricitabine/tenofovir alafenamide FDC|Drug: Darunavir|Drug: Cobicistat Janssen Sciences Ireland UC Phase 1 2015-11-01 2016-04-06
    NCT01345630 HIV-1 Drug: Maraviroc|Drug: Emtricitabine/tenofovir|Drug: darunavir/ritonavir 800/100 mg|Drug: placebo for emtricitabine/tenofovir|Drug: placebo for maraviroc ViiV Healthcare|Pfizer Phase 3 2011-09-01 2015-12-11
    NCT03060785 HIV Prevention Drug: Tenofovir Disoproxil Fumarate/Emtricitabine Johns Hopkins University Phase 1 2016-03-08 2017-02-17
    NCT01715636 HIV Nonoccupational Post-exposure Prophylaxis in Men Who Have Sex With Men Drug: Eviplera = emtricitabine 200mg, rilpivirine 25mg, tenofovir 245mg Andrew Carr|St Vincent's Hospital, Sydney Phase 4 2012-12-01 2015-01-08
    NCT00524173 Hepatitis B Drug: Tenofovir/ & Emtricitabine|Drug: Tenofovir National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC) Phase 2 2007-08-29 2017-02-17
    NCT01066962 HIV Infections Drug: darunavir/ritonavir QD + raltegravir BID|Drug: darunavir/r QD + tenofovir/emtricitabine QD (fixed dose combination) French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|NEAT - European AIDS Treatment Network Phase 3 2010-08-01 2013-11-05
    NCT01605890 HIV-2 Infection Drug: emtricitabine / tenofovir disoproxil fumarate / raltegravir . French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Gilead Sciences|Merck Sharp & Dohme Corp. Phase 2 2012-07-01 2016-07-11
    NCT01576731 HIV Infection Drug: Tenofovir, Emtricitabine, Lopinavir/r|Drug: Tenofovir, Emtricitabine, Raltegravir Hospital Clinic of Barcelona Phase 4 2012-07-01 2015-03-31

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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