Cidofovir可通过抑制病毒DNA聚合酶活性以控制巨细胞病毒CMV复制。
Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Snoeck R, et al, Antimicrob Agents Chemother, 1988, 32(12), 1839-1844.
[2] Cundy KC, et al. Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients. Antimicrob Agents Chemother. 1995 Jun;39(6):1247-52.
[3] Polis MA, et al. Anticytomegaloviral activity and safety of cidofovir in patients with human immunodeficiency virus infection and cytomegalovirus viruria. Antimicrob Agents Chemother. 1995 Apr;39(4):882-6.
分子式 C8H14N3O6P |
分子量 279.19 |
CAS号 113852-37-2 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO <1 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01816646 | Blood And Marrow Transplantation | Drug: Cidofovir|Drug: Probenecid | M.D. Anderson Cancer Center|Gilead Sciences | Phase 1 | 2013-09-01 | 2016-12-02 |
NCT01866397 | Cytomegalovirus Retinitis|Acute Renal Failure | Other: Cidofovir pharmacokinetics | Medical University of Vienna|University of Vienna | Phase 4 | 2002-03-01 | 2013-06-04 |
NCT00956176 | Cystitis|Bladder Diseases | Drug: Cidofovir | M.D. Anderson Cancer Center|Gilead Sciences | 2012-09-01 | 2012-09-05 | |
NCT01295645 | Transplantation Infection | Drug: Cidofovir|Other: No Cidofovir | M.D. Anderson Cancer Center | Phase 2 | 2011-03-01 | 2016-05-18 |
NCT02567149 | Warts | Drug: Cidofovir | University of Minnesota - Clinical and Translational Science Institute | Phase 2 | 2016-07-01 | 2016-05-10 |
NCT00948506 | Prevention of Hair Growth | Drug: 1% topical cidofovir|Drug: 3% topical cidofovir|Drug: Placebo | University of Pennsylvania | Phase 2 | 2009-07-01 | 2012-03-16 |
NCT00138424 | BK Virus (Nephropathy) | Drug: Cidofovir|Drug: Placebo | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1|Phase 2 | 2006-05-01 | 2013-02-28 |
NCT00205374 | Recurrent Respiratory Papillomatosis | Drug: Cidofovir|Drug: Placebo | University of Wisconsin, Madison | Phase 4 | 1999-11-01 | 2012-03-30 |
NCT02976987 | High Grade Cervical Epithelial Neoplasia (CIN2+) | Drug: Cidofovir | Brugmann University Hospital | Phase 2 | 2013-02-01 | 2016-11-25 |
NCT01946009 | HIV | Drug: Cidofovir 1% cream's basis, 2gr, three times per week, during 4 weeks. | Fundacion SEIMC-GESIDA | 2013-09-01 | 2016-06-28 | |
NCT00550589 | Anal Cancer|Precancerous Condition | Drug: cidofovir|Genetic: DNA methylation analysis|Genetic: gene expression analysis|Genetic: polymerase chain reaction|Procedure: biopsy|Procedure: histopathologic examination | AIDS Malignancy Consortium|National Cancer Institute (NCI)|The EMMES Corporation | Phase 2 | 2007-09-01 | 2015-11-17 |
NCT00000143 | Cytomegalovirus Retinitis|HIV Infections | Device: Ganciclovir implant and oral ganciclovir|Drug: Cidofovir intravenous | Johns Hopkins Bloomberg School of Public Health | Phase 3 | 1997-05-01 | 2016-02-18 |
NCT00989443 | Uterine Cervical Neoplasms|Cervix Intraepithelial Neoplasia | Drug: Cidofovir gel | Mithra Pharmaceuticals | Phase 1 | 2010-05-01 | 2010-10-20 |
NCT00002181 | Herpes Simplex|HIV Infections | Drug: Cidofovir | Gilead Sciences|NIH AIDS Clinical Trials Information Service | 2005-06-23 | ||
NCT00002116 | Herpes Simplex|HIV Infections | Drug: Cidofovir | Gilead Sciences|NIH AIDS Clinical Trials Information Service | Phase 1 | 2005-06-23 | |
NCT00001126 | Papilloma | Drug: Cidofovir | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 | 2010-08-26 | |
NCT00002327 | HIV Infections|Condyloma Acuminata | Drug: Cidofovir | Gilead Sciences|NIH AIDS Clinical Trials Information Service | Phase 1 | 2005-06-23 | |
NCT00000881 | Cytomegalovirus Infections|Cytomegalovirus Retinitis|HIV Infections | Drug: Cidofovir|Drug: Probenecid | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 | 2012-02-16 | |
NCT00000142 | HIV Infections|CMV Cytomegalovirus Retinitis | Drug: Cidofovir | Johns Hopkins Bloomberg School of Public Health|Baylor College of Medicine|Johns Hopkins University|Louisiana State University Health Sciences Center in New Orleans|Icahn School of Medicine at Mount Sinai|New Jersey Medical School|New York University School of Medicine|Northwestern University|University of California, Los Angeles|University of California, San Diego|University of California, San Francisco|University of Miami|University of North Carolina, Chapel Hill|University of South Florida | Phase 2|Phase 3 | 1994-04-01 | 2015-10-14 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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