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Cidofovir

西多福韦,西多夫韦,昔多呋韦,GS-0504,GS0504,HPMPC,GS 0504,Vistide,(S)-HPMPC

Cidofovir可通过抑制病毒DNA聚合酶活性以控制巨细胞病毒CMV复制。

目录号
EY0773
EY0773
EY0773
EY0773
纯度
99.62%
99.62%
99.62%
99.62%
规格
5 mg
10 mg
50 mg
100 mg
原价
310
425
880
1300
售价
310
425
880
1300
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Snoeck R, et al, Antimicrob Agents Chemother, 1988, 32(12), 1839-1844.
    [2] Cundy KC, et al. Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients. Antimicrob Agents Chemother. 1995 Jun;39(6):1247-52.
    [3] Polis MA, et al. Anticytomegaloviral activity and safety of cidofovir in patients with human immunodeficiency virus infection and cytomegalovirus viruria. Antimicrob Agents Chemother. 1995 Apr;39(4):882-6.

    分子式
    C8H14N3O6P
    分子量
    279.19
    CAS号
    113852-37-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    <1 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01816646 Blood And Marrow Transplantation Drug: Cidofovir|Drug: Probenecid M.D. Anderson Cancer Center|Gilead Sciences Phase 1 2013-09-01 2016-12-02
    NCT01866397 Cytomegalovirus Retinitis|Acute Renal Failure Other: Cidofovir pharmacokinetics Medical University of Vienna|University of Vienna Phase 4 2002-03-01 2013-06-04
    NCT00956176 Cystitis|Bladder Diseases Drug: Cidofovir M.D. Anderson Cancer Center|Gilead Sciences 2012-09-01 2012-09-05
    NCT01295645 Transplantation Infection Drug: Cidofovir|Other: No Cidofovir M.D. Anderson Cancer Center Phase 2 2011-03-01 2016-05-18
    NCT02567149 Warts Drug: Cidofovir University of Minnesota - Clinical and Translational Science Institute Phase 2 2016-07-01 2016-05-10
    NCT00948506 Prevention of Hair Growth Drug: 1% topical cidofovir|Drug: 3% topical cidofovir|Drug: Placebo University of Pennsylvania Phase 2 2009-07-01 2012-03-16
    NCT00138424 BK Virus (Nephropathy) Drug: Cidofovir|Drug: Placebo National Institute of Allergy and Infectious Diseases (NIAID) Phase 1|Phase 2 2006-05-01 2013-02-28
    NCT00205374 Recurrent Respiratory Papillomatosis Drug: Cidofovir|Drug: Placebo University of Wisconsin, Madison Phase 4 1999-11-01 2012-03-30
    NCT02976987 High Grade Cervical Epithelial Neoplasia (CIN2+) Drug: Cidofovir Brugmann University Hospital Phase 2 2013-02-01 2016-11-25
    NCT01946009 HIV Drug: Cidofovir 1% cream's basis, 2gr, three times per week, during 4 weeks. Fundacion SEIMC-GESIDA 2013-09-01 2016-06-28
    NCT00550589 Anal Cancer|Precancerous Condition Drug: cidofovir|Genetic: DNA methylation analysis|Genetic: gene expression analysis|Genetic: polymerase chain reaction|Procedure: biopsy|Procedure: histopathologic examination AIDS Malignancy Consortium|National Cancer Institute (NCI)|The EMMES Corporation Phase 2 2007-09-01 2015-11-17
    NCT00000143 Cytomegalovirus Retinitis|HIV Infections Device: Ganciclovir implant and oral ganciclovir|Drug: Cidofovir intravenous Johns Hopkins Bloomberg School of Public Health Phase 3 1997-05-01 2016-02-18
    NCT00989443 Uterine Cervical Neoplasms|Cervix Intraepithelial Neoplasia Drug: Cidofovir gel Mithra Pharmaceuticals Phase 1 2010-05-01 2010-10-20
    NCT00002181 Herpes Simplex|HIV Infections Drug: Cidofovir Gilead Sciences|NIH AIDS Clinical Trials Information Service 2005-06-23
    NCT00002116 Herpes Simplex|HIV Infections Drug: Cidofovir Gilead Sciences|NIH AIDS Clinical Trials Information Service Phase 1 2005-06-23
    NCT00001126 Papilloma Drug: Cidofovir National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 2010-08-26
    NCT00002327 HIV Infections|Condyloma Acuminata Drug: Cidofovir Gilead Sciences|NIH AIDS Clinical Trials Information Service Phase 1 2005-06-23
    NCT00000881 Cytomegalovirus Infections|Cytomegalovirus Retinitis|HIV Infections Drug: Cidofovir|Drug: Probenecid National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 2012-02-16
    NCT00000142 HIV Infections|CMV Cytomegalovirus Retinitis Drug: Cidofovir Johns Hopkins Bloomberg School of Public Health|Baylor College of Medicine|Johns Hopkins University|Louisiana State University Health Sciences Center in New Orleans|Icahn School of Medicine at Mount Sinai|New Jersey Medical School|New York University School of Medicine|Northwestern University|University of California, Los Angeles|University of California, San Diego|University of California, San Francisco|University of Miami|University of North Carolina, Chapel Hill|University of South Florida Phase 2|Phase 3 1994-04-01 2015-10-14

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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