Home > CFTR & > Ivacaftor

Ivacaftor

依伐卡托,VX-770,Kalydeco,VX 770,VX770,

Ivacaftor是CFTR的增强剂,对G551D-CFTR和F508del-CFTR的EC50分别为100 nM和25 nM。

目录号
EY0770
EY0770
EY0770
纯度
99.49%
99.49%
99.49%
规格
1 mg
5 mg
10 mg
原价
220
485
720
售价
220
485
720
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM in fisher rat thyroid cells, respectively.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Van Goor F, et al. Proc Natl Acad Sci U S A, 2009, 106(44), 18825-18830.
    [2] Accurso FJ, et al. Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation. N Engl J Med. 2010 Nov 18;363(21):1991-2003.

    分子式
    C24H28N2O3
    分子量
    392.49
    CAS号
    873054-44-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    78 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02194881 Cystic Fibrosis Drug: CF patients with a G551D mutation and treated with Ivacaftor Assistance Publique - H么pitaux de Paris|Vaincre la Mucoviscidose 2014-10-01 2016-07-31
    NCT01784419 Cystic Fibrosis Drug: ivacaftor University of California, San Francisco 2013-10-01 2014-10-17
    NCT01705145 Cystic Fibrosis Drug: Ivacaftor Vertex Pharmaceuticals Incorporated|Cystic Fibrosis Foundation Therapeutics Phase 3 2013-01-01 2016-03-09
    NCT03085485 Chronic Obstructive Pulmonary Disease|Chronic Bronchitis Drug: Ivacaftor 150 MG|Drug: Placebo University of Alabama at Birmingham|National Heart, Lung, and Blood Institute (NHLBI)|Vertex Pharmaceuticals Incorporated Phase 2 2017-03-01 2017-03-14
    NCT02310789 Cystic Fibrosis Drug: Ivacaftor Richard Barry Moss|Stanford University Early Phase 1 2015-07-01 2016-04-23
    NCT01614457 Cystic Fibrosis Drug: Ivacaftor|Drug: Placebo Vertex Pharmaceuticals Incorporated|Cystic Fibrosis Foundation Therapeutics Phase 3 2012-07-01 2015-01-31
    NCT01946412 Cystic Fibrosis Drug: Ivacaftor Vertex Pharmaceuticals Incorporated|Cystic Fibrosis Foundation Therapeutics Phase 3 2013-12-01 2016-12-06
    NCT01707290 Cystic Fibrosis Drug: ivacaftor Vertex Pharmaceuticals Incorporated|Cystic Fibrosis Foundation Therapeutics Phase 3 2013-02-01 2016-05-10
    NCT02934698 Cystic Fibrosis Drug: Ivacaftor Medical University of South Carolina|Vertex Pharmaceuticals Incorporated Phase 3 2016-10-01 2016-10-14
    NCT02725567 Cystic Fibrosis Drug: ivacaftor Vertex Pharmaceuticals Incorporated Phase 3 2016-03-01 2017-03-22
    NCT01899105 Cystic Fibrosis Drug: lumacaftor|Drug: ivacaftor Vertex Pharmaceuticals Incorporated Phase 1 2013-07-01 2014-04-02
    NCT02412111 Cystic Fibrosis Drug: ivacaftor|Drug: VX-661|Drug: Placebo Vertex Pharmaceuticals Incorporated Phase 3 2015-06-01 2017-02-23
    NCT02135432 Chronic Obstructive Pulmonary Disease Drug: Ivacaftor|Drug: Placebo University of Alabama at Birmingham Early Phase 1 2015-05-01 2017-01-05
    NCT01897233 Cystic Fibrosis Drug: Lumacaftor|Drug: Ivacaftor Vertex Pharmaceuticals Incorporated Phase 3 2013-07-01 2016-10-07
    NCT01614470 Cystic Fibrosis Drug: Ivacaftor|Drug: Placebo Vertex Pharmaceuticals Incorporated|Cystic Fibrosis Foundation Therapeutics Phase 3 2012-07-01 2014-10-23
    NCT02565914 Cystic Fibrosis Drug: VX-661/ivacaftor|Drug: ivacaftor Vertex Pharmaceuticals Incorporated Phase 3 2015-08-01 2016-04-27
    NCT01685801 Cystic Fibrosis Drug: Ivacaftor|Drug: Placebo-matched-to-ivacaftor tablet Vertex Pharmaceuticals Incorporated Phase 2 2012-09-01 2015-04-30
    NCT00953706 Cystic Fibrosis Drug: Ivacaftor|Drug: Placebo Vertex Pharmaceuticals Incorporated|Cystic Fibrosis Foundation Therapeutics Phase 2 2009-09-01 2015-08-27
    NCT03068312 Cystic Fibrosis Drug: Ivacaftor|Drug: Placebo Vertex Pharmaceuticals Incorporated Phase 3 2017-04-25 2017-02-24
    NCT02742519 Cystic Fibrosis Drug: ivacaftor|Drug: Placebo Vertex Pharmaceuticals Incorporated Phase 3 2016-05-01 2016-12-12

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 :
  • 收件地址 :
  • 电话号码 :
  • 单位名称 :
  • 产品货号 :
  • 产品规格 :
  • 发票抬头以及单位税号 :