Nizatidine

尼扎替丁

Nizatidine是一种组胺H2受体拮抗剂,作用于AChE,IC50为6.7 nM。

目录号
EY0767
EY0767
EY0767
纯度
99.34%
99.34%
99.34%
规格
100 mg
500 mg
1 g
原价
330
365
390
售价
330
365
390
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Nizatidine is a histamine H2 receptor antagonist with IC50 of 0.9 nM, also inhibits AChE with IC50 of 6.7 μM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

    0.5-10微摩尔/千克皮下注射

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Lin TM, et al. J Pharmacol Exp Ther, 1986, 239(2), 406-410.
    [2] Abdel-Rahman, Susan M., et al., 2004. Developmental pharmacokinetics and pharmacodynamics of nizatidine. Journal of pediatric gastroenterology and nutrition. 38(4): 442-51.

    分子式
    C12H21N5O2S2
    分子量
    331.46
    CAS号
    76963-41-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    65 mg/mL
    Water
    27 mg/mL
    Ethanol
    18 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01161940 Healthy Drug: Nizatidine|Drug: Axid Dr. Reddy's Laboratories Limited Phase 1 2004-07-01 2010-07-13
    NCT01409395 Healthy Drug: Metformin and nizatidine|Drug: Metformin University of California, San Francisco|National Institute of General Medical Sciences (NIGMS) Phase 1 2011-09-01 2014-04-09
    NCT01161927 Healthy Drug: Nizatidine|Drug: Axid Dr. Reddy's Laboratories Limited Phase 1 2004-07-01 2010-07-13
    NCT02232308 Gastroparesis Drug: Nizatidine|Drug: Lisinopril|Drug: Placebo Adil Bharucha|National Center for Research Resources (NCRR)|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Mayo Clinic Phase 1 2014-07-01 2015-04-28
    NCT00373334 Gastroesophageal Reflux Disease|GERD|Heartburn Drug: nizatidine (axid)|Drug: nizatidine (axid)|Drug: placebo Braintree Laboratories Phase 3 2006-08-01 2009-11-17
    NCT00486005 Schizophrenia Drug: Olanzapine Hydrochloride|Drug: Nizatidine|Drug: Placebo Eli Lilly and Company Phase 4 2003-02-01 2007-06-11
    NCT02703896 Pulmonary Aspiration of Gastric Contents Drug: Drug either PPIS or H2RA and prokinetics|Procedure: orogastric intubation King Saud University Phase 4 2012-01-01 2016-03-08
    NCT02951715 Hearing Loss, Noise-Induced|Tinnitus, Noise Induced|Zinc Deficiency Drug: zinc gluconate Chang Gung Memorial Hospital|Chang Gung University 2013-12-01 2016-10-31
    NCT02555852 Gastroesophageal Reflux Disease (GERD)|Community-acquired Pneumonia Drug: esomeprazole|Drug: omeprazole|Drug: pantoprazole|Drug: lansoprazole|Drug: rabeprazole|Drug: cimetidine|Drug: ranitidine|Drug: famotidine|Drug: nizatidine|Drug: niperotidine|Drug: roxatidine|Drug: ranitidine bismuth citrate|Drug: lafutidine|Drug: cimetidine combinations|Drug: famotidine combinations Canadian Network for Observational Drug Effect Studies, CNODES|Drug Safety and Effectiveness Network, Canada|Canadian Institutes of Health Research (CIHR) 2011-09-01 2015-09-18

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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