Nizatidine是一种组胺H2受体拮抗剂,作用于AChE,IC50为6.7 nM。
Nizatidine is a histamine H2 receptor antagonist with IC50 of 0.9 nM, also inhibits AChE with IC50 of 6.7 μM.
0.5-10微摩尔/千克皮下注射
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Lin TM, et al. J Pharmacol Exp Ther, 1986, 239(2), 406-410.
[2] Abdel-Rahman, Susan M., et al., 2004. Developmental pharmacokinetics and pharmacodynamics of nizatidine. Journal of pediatric gastroenterology and nutrition. 38(4): 442-51.
分子式 C12H21N5O2S2 |
分子量 331.46 |
CAS号 76963-41-2 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 65 mg/mL |
Water 27 mg/mL |
Ethanol 18 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01161940 | Healthy | Drug: Nizatidine|Drug: Axid | Dr. Reddy's Laboratories Limited | Phase 1 | 2004-07-01 | 2010-07-13 |
NCT01409395 | Healthy | Drug: Metformin and nizatidine|Drug: Metformin | University of California, San Francisco|National Institute of General Medical Sciences (NIGMS) | Phase 1 | 2011-09-01 | 2014-04-09 |
NCT01161927 | Healthy | Drug: Nizatidine|Drug: Axid | Dr. Reddy's Laboratories Limited | Phase 1 | 2004-07-01 | 2010-07-13 |
NCT02232308 | Gastroparesis | Drug: Nizatidine|Drug: Lisinopril|Drug: Placebo | Adil Bharucha|National Center for Research Resources (NCRR)|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Mayo Clinic | Phase 1 | 2014-07-01 | 2015-04-28 |
NCT00373334 | Gastroesophageal Reflux Disease|GERD|Heartburn | Drug: nizatidine (axid)|Drug: nizatidine (axid)|Drug: placebo | Braintree Laboratories | Phase 3 | 2006-08-01 | 2009-11-17 |
NCT00486005 | Schizophrenia | Drug: Olanzapine Hydrochloride|Drug: Nizatidine|Drug: Placebo | Eli Lilly and Company | Phase 4 | 2003-02-01 | 2007-06-11 |
NCT02703896 | Pulmonary Aspiration of Gastric Contents | Drug: Drug either PPIS or H2RA and prokinetics|Procedure: orogastric intubation | King Saud University | Phase 4 | 2012-01-01 | 2016-03-08 |
NCT02951715 | Hearing Loss, Noise-Induced|Tinnitus, Noise Induced|Zinc Deficiency | Drug: zinc gluconate | Chang Gung Memorial Hospital|Chang Gung University | 2013-12-01 | 2016-10-31 | |
NCT02555852 | Gastroesophageal Reflux Disease (GERD)|Community-acquired Pneumonia | Drug: esomeprazole|Drug: omeprazole|Drug: pantoprazole|Drug: lansoprazole|Drug: rabeprazole|Drug: cimetidine|Drug: ranitidine|Drug: famotidine|Drug: nizatidine|Drug: niperotidine|Drug: roxatidine|Drug: ranitidine bismuth citrate|Drug: lafutidine|Drug: cimetidine combinations|Drug: famotidine combinations | Canadian Network for Observational Drug Effect Studies, CNODES|Drug Safety and Effectiveness Network, Canada|Canadian Institutes of Health Research (CIHR) | 2011-09-01 | 2015-09-18 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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