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Pilocarpine HCl

盐酸毛果芸香碱,BMS-863233,XL-413,XL 413,XL-413,BMS 863233,BMS863233,

Pilocarpine HCl是一种非选择性的毒蕈碱型乙酰胆碱受体激动剂，用于产生癫痫的实验模型。

目录号
EY0766
EY0766
EY0766
纯度
99.33%
99.33%
99.33%
规格
50 mg
100 mg
500 mg
原价
225
380
970
售价
225
380
970
库存
现货
现货
现货
订购
订购
订购
订购
订购
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  • 生物活性

    Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Maslanski JA, et al. Neurosci Lett, 1994, 168(1-2), 225-228.
    [2] Dubé, C., et al. 2000. Exp. Neurol. 162: 146-157.
    [3] Mayorga, A.J., et al. 1999. Eur. J. Pharmacol. 364: 7-11.
    [4] Cavalheiro, E.A. 1995. Ital J Neurol Sci. 16: 33-37.

    分子式
    C11H17ClN2O2    		 分子量
    244.72    		 CAS号
    54-71-7    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    50 mg/mL    		 Water
    50 mg/mL    		 Ethanol
    50 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02982577 Xerostomia Drug: Pilocarpine|Other: Spray without Pilocarpine University of Sao Paulo Phase 4 2016-04-01 2016-11-30
    NCT02754570 Glaucoma, Open-angle|Hypertension, Ocular Drug: Pilocarpine University of Colorado, Denver 2016-07-01 2017-01-10
    NCT02447315 Healthy Subjects Drug: Pilocarpine|Drug: Placebo Astellas Pharma Europe B.V.|Astellas Pharma Inc Phase 1 2015-05-01 2015-08-10
    NCT00438048 Primary Sjogren|Secondary Sjogren|Xerostomia Procedure: pilocarpine|Drug: Artificial Saliva Pontificia Universidad Catolica de Chile|Formulario MAgistral Farmacias Ahumada Phase 4 2006-11-01 2008-05-21
    NCT00003139 Head and Neck Cancer|Oral Complications Drug: pilocarpine hydrochloride|Other: Placebo Radiation Therapy Oncology Group|National Cancer Institute (NCI) Phase 3 1998-03-01 2015-11-14
    NCT01627626 Xerostomia Drug: Pilocarpine|Drug: saline Jeong-seong Kwon|Yonsei University 2011-08-01 2012-06-21
    NCT00803803 Open-angle Glaucoma Drug: Pilocarpine Concentration|Drug: Pilocarpine Frequency Wills Eye Phase 4 1978-08-01 2016-11-20
    NCT01690052 Dry Mouth Drug: Cevimeline|Drug: Pilocarpine University of Kentucky 2009-01-01 2014-08-05
    NCT00003686 Oral Complications|Quality of Life Drug: pilocarpine hydrochloride|Drug: Placebo NCIC Clinical Trials Group|Canadian Cancer Trials Group Phase 3 1998-08-01 2013-05-30
    NCT00168181 Cancer|Head and Neck Cancer Procedure: Submandibular gland Transfer|Drug: Salagen Alberta Health Services|CancerCare Manitoba|Jewish General Hospital|Newfoundland Cancer Treatment & Research Foundation|Notre-dame Hospital|Ottawa Hospital Research Institute|AHS Cancer Control Alberta Phase 3 2002-04-01 2011-04-15
    NCT00343382 Breast Cancer|Vaginal Dryness Drug: pilocarpine hydrochloride|Other: placebo Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) Phase 3 2006-12-01 2016-07-12
    NCT00656513 Head and Neck Cancer|Xerostomia Drug: pilocarpine hydrochloride|Procedure: acupuncture-like transcutaneous electrical nerve stimulation Radiation Therapy Oncology Group|National Cancer Institute (NCI)|NRG Oncology Phase 2|Phase 3 2008-09-01 2015-03-26
    NCT00762645 Angle-Closure Glaucoma Drug: Travoprost 0.004% (Travatan)|Drug: Pilocarpine 1% Alcon Research Phase 4 2007-02-01 2010-03-12
    NCT00618059 Dry Mouth Drug: Pilocarpine Roxane Laboratories 2004-08-01 2008-02-15
    NCT00601874 Dry Mouth Drug: Pilocarpine Roxane Laboratories 2003-09-01 2008-01-31
    NCT00602524 Dry Mouth Drug: Pilocarpine Roxane Laboratories 2004-08-01 2008-02-05
    NCT00624039 Presbyopia|Cataract Other: UBM with pilocarpine in presbyopia Samsung Medical Center 2006-05-01 2008-02-18
    NCT00804115 Exfoliation Syndrome|Glaucoma|Ocular Hypertension Drug: Latanoprost with Pilocarpine vs Timolol or Cosopt The New York Eye & Ear Infirmary|Pfizer 2000-08-01 2008-12-05
    NCT00601211 Dry Mouth Drug: Pilocarpine Roxane Laboratories 2003-09-01 2008-01-31
    NCT01036035 Incontinence Drug: Tolterodine|Drug: Pilocarpine|Drug: THVD-201|Drug: THVD-201|Drug: placebo capsule TheraVida, Inc. Phase 1 2009-09-01 2015-12-28

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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